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English
RB regulates the stability and the apoptotic function of p53 via MDM2
scientific article published on 01 February 1999
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instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10078201
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10078201%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 November 2019
title
RB regulates the stability and the apoptotic function of p53 via MDM2
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10078201
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10078201%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 November 2019
main subject
apoptotic process
1 reference
based on heuristic
inferred from title
author name string
J K Hsieh
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10078201
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10078201%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 November 2019
F S Chan
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10078201
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10078201%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 November 2019
D J O'Connor
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10078201
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10078201%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 November 2019
S Mittnacht
series ordinal
4
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10078201
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10078201%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 November 2019
S Zhong
series ordinal
5
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10078201
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10078201%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 November 2019
X Lu
series ordinal
6
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10078201
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10078201%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 November 2019
publication date
1 February 1999
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10078201
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10078201%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 November 2019
published in
Molecular Cell
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10078201
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10078201%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 November 2019
volume
3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10078201
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10078201%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 November 2019
issue
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10078201
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10078201%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 November 2019
page(s)
181-193
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10078201
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10078201%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 November 2019
cites work
Deletion of RB exons 24 and 25 causes low-penetrance retinoblastoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980309-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
pRB phosphorylation mutants reveal role of pRB in regulating S phase completion by a mechanism independent of E2F.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980309-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Rb family contains a conserved cyclin-dependent-kinase-regulated transcriptional repressor motif
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980309-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transcriptional activation by p53 correlates with suppression of growth but not transformation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980309-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
High level expression of p27(kip1) and cyclin D1 in some human breast cancer cells: inverse correlation between the expression of p27(kip1) and degree of malignancy in human breast and colorectal cancers
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980309-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980309-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
E2F-1-induced p53-independent apoptosis in transgenic mice.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980309-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980309-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Two distinct signaling pathways activate the latent DNA binding function of p53 in a casein kinase II-independent manner.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980309-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of the specific DNA binding function of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980309-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980309-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bax-deficient mice with lymphoid hyperplasia and male germ cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980309-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53: puzzle and paradigm
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980309-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of p53 stability by Mdm2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980309-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53, the cellular gatekeeper for growth and division
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980309-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980309-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Control of pRB phosphorylation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980309-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980309-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Physical and functional interactions between p53 and cell cycle co-operating transcription factors, E2F1 and DP1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980309-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980309-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Signaling to p53: breaking the MDM2-p53 circuit
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980309-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980309-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cancer cell cycles
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980309-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Repression of p53-mediated transcription by MDM2: a dual mechanism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980309-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980309-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The retinoblastoma protein and cell cycle control
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980309-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanism of active transcriptional repression by the retinoblastoma protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980309-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980309-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 and E2F-1 cooperate to mediate apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980309-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interaction between the retinoblastoma protein and the oncoprotein MDM2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980309-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Altered retinoblastoma protein expression and prognosis in early-stage non-small-cell lung carcinoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980309-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S1097-2765(00)80309-3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10078201
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10078201%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 November 2019
PubMed publication ID
10078201
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10078201
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10078201%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 November 2019
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