(Q33233462)

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MTH1, an oxidized purine nucleoside triphosphatase, suppresses the accumulation of oxidative damage of nucleic acids in the hippocampal microglia during kainate-induced excitotoxicity.

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16467516%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

MTH1, an oxidized purine nucleoside triphosphatase, suppresses the accumulation of oxidative damage of nucleic acids in the hippocampal microglia during kainate-induced excitotoxicity (English)

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Europe PubMed Central

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16 January 2020

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Kosuke Kajitani

1

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16 January 2020

Yusaku Nakabeppu

6

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16 January 2020

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Hiroo Yamaguchi

2

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16 January 2020

Yukihiko Dan

3

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16 January 2020

Masato Furuichi

4

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16 January 2020

Dongchon Kang

5

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16 January 2020

language of work or name

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publication date

1 February 2006

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16 January 2020

Journal of Neuroscience

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16467516%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

26

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16 January 2020

6

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Europe PubMed Central

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16 January 2020

1688-1698

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16467516%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Hippocampal sclerosis revisited

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective response of various brain cell types during neurodegeneration induced by mild impairment of oxidative metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of 8-oxoguanine DNA glycosylase (OGG1) in Parkinson's disease and related neurodegenerative disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular diversity of glutamate receptors and implications for brain function

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of hMTH1 in the hippocampi of control and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Minireview. Kainic acid as a tool for the study of temporal lobe epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Base excision repair of 8-hydroxyguanine protects DNA from endogenous oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mouse MTH1 protein with 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphatase activity that prevents transversion mutation. cDNA cloning and tissue distribution

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MTH1, an oxidized purine nucleoside triphosphatase, protects the dopamine neurons from oxidative damage in nucleic acids caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genomic structure and chromosome location of the human mutT homologue gene MTH1 encoding 8-oxo-dGTPase for prevention of A:T to C:G transversion

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress, glutamate, and neurodegenerative disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Seizure-induced alterations of plasma membrane calcium ATPase isoforms 1, 2 and 3 mRNA and protein in rat hippocampus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Counteraction by MutT protein of transcriptional errors caused by oxidative damage.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human APE2 protein is mostly localized in the nuclei and to some extent in the mitochondria, while nuclear APE2 is partly associated with proliferating cell nuclear antigen

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Melatonin maintains glutathione homeostasis in kainic acid-exposed rat brain tissues.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reactive microgliosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kainic acid-mediated excitotoxicity as a model for neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Actions of several anthelmintics and insecticides on rat cortical neurones

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An oxidized purine nucleoside triphosphatase, MTH1, suppresses cell death caused by oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kainate-evoked changes in dystrophin messenger RNA levels in the rat hippocampus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human mitochondrial DNA is packaged with TFAM.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional cooperation of MutT, MutM and MutY proteins in preventing mutations caused by spontaneous oxidation of guanine nucleotide in Escherichia coli.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

G protein mechanisms: insights from structural analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Roles and rules of kainate receptors in synaptic transmission.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloned glutamate receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impairment of mitochondrial DNA repair enzymes against accumulation of 8-oxo-guanine in the spinal motor neurons of amyotrophic lateral sclerosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AMPA-kainate subtypes of glutamate receptor in rat cerebral microglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression and differential intracellular localization of two major forms of human 8-oxoguanine DNA glycosylase encoded by alternatively spliced OGG1 mRNAs

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accumulation of 8-oxoguanine in the cellular DNA and the alteration of the OGG1 expression during ischemia-reperfusion injury in the rat kidney.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation of the base modification 8-hydroxyl-2'-deoxyguanosine and DNA fragmentation following seizures induced by systemic kainic acid in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered expression of NPY-Y1 receptors in kainic acid induced epilepsy in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anatomical studies of DNA fragmentation in rat brain after systemic kainate administration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic fate of oxidized guanine ribonucleotides in mammalian cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of the lipid peroxidation product malonaldehyde in rat brain in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kainic acid: a powerful neurotoxic analogue of glutamate.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and characterization of two forms of mouse MUTYH proteins encoded by alternatively spliced transcripts

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ogg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that MutY and MutM combine to prevent mutations by an oxidatively damaged form of guanine in DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GABA(A) receptor subunits in the rat hippocampus III: altered messenger RNA expression in kainic acid-induced epilepsy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kainic acid-induced neuronal death is associated with DNA damage and a unique immediate-early gene response in c-fos-lacZ transgenic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative damage is the earliest event in Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age dependence of seizure-induced oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxygen free radicals in rat limbic structures after kainate-induced seizures.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16467516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.4948-05.2006

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16467516%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16467516%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16467516%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

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