(Q33271332)

24 July 2017

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title

Spider venoms: a rich source of acylpolyamines and peptides as new leads for CNS drugs (English)

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24 July 2017

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Georgina Estrada

1

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Gerardo Corzo

object named as

Gerardo Corzo

series ordinal

3

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author name string

Elba Villegas

series ordinal

2

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24 July 2017

publication date

6 December 2006

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24 July 2017

published in

Natural Product Reports

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24 July 2017

volume

24

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24 July 2017

issue

1

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24 July 2017

page(s)

145-161

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Polypeptide neurotoxins from spider venoms

24 July 2017

cites work

1 reference

Structure and pharmacology of spider venom neurotoxins

21 January 2018

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Oxyopinins, large amphipathic peptides isolated from the venom of the wolf spider Oxyopes kitabensis with cytolytic properties and positive insecticidal cooperativity with spider neurotoxins.

21 January 2018

1 reference

Venom landscapes: mining the complexity of spider venoms via a combined cDNA and mass spectrometric approach

21 January 2018

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Tarantulas: eight-legged pharmacists and combinatorial chemists

21 January 2018

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Recent advances in the medicinal chemistry of polyamine toxins

21 January 2018

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Isolation and characterisation of glutamate receptor antagonists from venoms of orb-web spiders

21 January 2018

1 reference

Synthesis and paralytic activities of squaryl amino acid-containing polyamine toxins.

21 January 2018

1 reference

An efficient and versatile synthesis of acylpolyamine spider toxins

21 January 2018

1 reference

Solid phase syntheses of polyamine toxins HO-416b and PhTX-433. Use of an efficient polyamide reduction strategy that facilitates access to branched analogues.

21 January 2018

1 reference

Glutamate receptor changes associated with transient anoxia/hypoglycaemia in hippocampal slice cultures

21 January 2018

1 reference

Involvement of glutamate receptors of the NMDA type in the modulation of acetylcholine and glutamate overflow from the guinea pig ileum during in vitro hypoxia and hypoglycaemia

21 January 2018

1 reference

Glutamate-based therapeutic approaches: NR2B receptor antagonists

21 January 2018

1 reference

Mechanically regulated expression of a neural glutamate transporter in bone: a role for excitatory amino acids as osteotropic agents?

21 January 2018

1 reference

Expression of an N-methyl-D-aspartate-type receptor by human and rat osteoblasts and osteoclasts suggests a novel glutamate signaling pathway in bone.

21 January 2018

1 reference

Spider venom contains specific receptor blocker of glutaminergic synapses

21 January 2018

1 reference

Spider toxin blocks excitatory amino acid responses in isolated hippocampal pyramidal neurons

21 January 2018

1 reference

Spider toxin (JSTX) blocks glutamate synapse in hippocampal pyramidal neurons

21 January 2018

1 reference

Spider venoms inhibit L-glutamate binding to brain synaptic membrane receptors

21 January 2018

1 reference

Structures and biological activities of three synaptic antagonists from orb weaver spider venom

21 January 2018

1 reference

An inhibitor of TRPV1 channels isolated from funnel Web spider venom.

21 January 2018

1 reference

Funnel-web spider venom and a toxin fraction block calcium current expressed from rat brain mRNA in Xenopus oocytes

21 January 2018

1 reference

A single amino acid determines the subunit-specific spider toxin block of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor channels

21 January 2018

1 reference

Pharmacological aspects of cytotoxic polyamine analogs and derivatives for cancer therapy

21 January 2018

1 reference

Putrescine transport is greatly increased in human fibroblasts initiated to proliferate

21 January 2018

1 reference

Labeled putrescine as a probe in brain tumors.

21 January 2018

1 reference

Polyamine spider toxins and mammalian N-methyl-D-aspartate receptors. Structural basis for channel blocking and binding of argiotoxin636.

21 January 2018

1 reference

Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage

21 January 2018

1 reference

Neuroprotection against ischemic/hypoxic brain damage: blockers of ionotropic glutamate receptor and voltage sensitive calcium channels

21 January 2018

1 reference

Ionotropic glutamate receptors: still a target for neuroprotection in brain ischemia? Insights from in vitro studies

21 January 2018

1 reference

A selective N-type calcium channel antagonist protects against neuronal loss after global cerebral ischemia

21 January 2018

1 reference

Blocking and isolation of a calcium channel from neurons in mammals and cephalopods utilizing a toxin fraction (FTX) from funnel-web spider poison

21 January 2018

1 reference

Differential inhibition of Ca2+ channels in mature rat cerebellar Purkinje cells by sFTX-3.3 and FTX-3.3.

21 January 2018

1 reference

L-arginyl-3,4-spermidine is neuroprotective in several in vitro models of neurodegeneration and in vivo ischaemia without suppressing synaptic transmission.

21 January 2018

1 reference

Characterisation of a novel class of polyamine-based neuroprotective compounds.

21 January 2018

1 reference

Mechanical allodynia in rats is blocked by a Ca2+ permeable AMPA receptor antagonist

21 January 2018

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Pain models display differential sensitivity to Ca2+-permeable non-NMDA glutamate receptor antagonists

21 January 2018

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Calcium-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/kainate receptors mediate development, but not maintenance, of secondary allodynia evoked by first-degree burn in the rat.

21 January 2018

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Spinal glutamate receptor antagonists differentiate primary and secondary mechanical hyperalgesia caused by incision.

21 January 2018

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Different receptors mediate motor neuron death induced by short and long exposures to excitotoxicity

21 January 2018

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Spider toxin and pertussis toxin differentiate post- and presynaptic glutamate receptors

21 January 2018

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A voltage-clamp study of the effects of Joro spider toxin and zinc on excitatory synaptic transmission in CA1 pyramidal cells of the guinea pig hippocampal slice

21 January 2018

1 reference

Classification of spider neurotoxins using structural motifs by primary structure features. Single residue distribution analysis and pattern analysis techniques.

21 January 2018

1 reference

Solution structure of hanatoxin1, a gating modifier of voltage-dependent K(+) channels: common surface features of gating modifier toxins

21 January 2018

1 reference

Pharmacologically active spider peptide toxins

21 January 2018

1 reference

A spider toxin that induces a typical effect of scorpion alpha-toxins but competes with beta-toxins on binding to insect sodium channels

21 January 2018

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Localization and molecular determinants of the Hanatoxin receptors on the voltage-sensing domains of a K(+) channel

21 January 2018

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A membrane-access mechanism of ion channel inhibition by voltage sensor toxins from spider venom

21 January 2018

1 reference

21 January 2018

The Protein Data Bank

1 reference

The voltage-gated potassium channels and their relatives

21 January 2018

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An inhibitor of the Kv2.1 potassium channel isolated from the venom of a Chilean tarantula

21 January 2018

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Reduction of I(to) causes hypertrophy in neonatal rat ventricular myocytes

21 January 2018

1 reference

Effects of phrixotoxins on the Kv4 family of potassium channels and implications for the role of Ito1 in cardiac electrogenesis

21 January 2018

1 reference

Electrophysiological and pharmacological correspondence between Kv4.2 current and rat cardiac transient outward current

21 January 2018

1 reference

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and high-performance liquid chromatography study of quantitative and qualitative variation in tarantula spider venoms

21 January 2018

1 reference

Modulation of Kv4.2 channels by a peptide isolated from the venom of the giant bird-eating tarantula Theraphosa leblondi

21 January 2018

1 reference

Neurotoxins: overview of an emerging research technology

21 January 2018

1 reference

Targeting N-type and T-type calcium channels for the treatment of pain

21 January 2018

1 reference

Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas

21 January 2018

1 reference

Solution structure of omega-grammotoxin SIA, a gating modifier of P/Q and N-type Ca(2+) channel

21 January 2018

1 reference

Suppression of inflammatory and neuropathic pain symptoms in mice lacking the N-type Ca2+ channel

21 January 2018

1 reference

Toxins in anti-nociception and anti-inflammation

21 January 2018

1 reference

SNX-325, a novel calcium antagonist from the spider Segestria florentina.

21 January 2018

1 reference

Blockade of neuromuscular transmission by huwentoxin-I, purified from the venom of the Chinese bird spider Selenocosmia huwena

21 January 2018

1 reference

Function and solution structure of Huwentoxin-X, a specific blocker of N-type calcium channels, from the Chinese bird spider Ornithoctonus huwena

21 January 2018

1 reference

ω-Phonetoxin-IIA: a calcium channel blocker from the spider Phoneutria nigriventer.

21 January 2018

1 reference

Inhibition of high voltage-activated calcium channels by spider toxin PnTx3-6.

21 January 2018

1 reference

Phoneutria nigriventer omega-phonetoxin IIA blocks the Cav2 family of calcium channels and interacts with omega-conotoxin-binding sites

21 January 2018

1 reference

Phoneutria nigriventer omega-Phonetoxin IIA: a new tool for anti-calcium channel autoantibody assays in Lambert-Eaton myasthenic syndrome

21 January 2018

1 reference

Neuroprotective effect on brain injury by neurotoxins from the spider Phoneutria nigriventer.

21 January 2018

1 reference

Evolution and divergence of sodium channel genes in vertebrates.

21 January 2018

1 reference

Regulation of Na+ channel distribution in the nervous system

21 January 2018

1 reference

Molecular mechanisms of neurotoxin action on voltage-gated sodium channels.

21 January 2018

1 reference

Jingzhaotoxin-III, a novel spider toxin inhibiting activation of voltage-gated sodium channel in rat cardiac myocytes

21 January 2018

1 reference

Jingzhaotoxin-I, a novel spider neurotoxin preferentially inhibiting cardiac sodium channel inactivation

21 January 2018

1 reference

Two tarantula peptides inhibit activation of multiple sodium channels

21 January 2018

1 reference

Amino acid sequence of versutoxin, a lethal neurotoxin from the venom of the funnel-web spider Atrax versutus

21 January 2018

1 reference

Modification of sodium channel gating and kinetics by versutoxin from the Australian funnel-web spider Hadronyche versuta.

21 January 2018

1 reference

Delta-atracotoxins from Australian funnel-web spiders compete with scorpion alpha-toxin binding on both rat brain and insect sodium channels

21 January 2018

1 reference

The structure of versutoxin (delta-atracotoxin-Hv1) provides insights into the binding of site 3 neurotoxins to the voltage-gated sodium channel

21 January 2018

1 reference

Solution structure of robustoxin, the lethal neurotoxin from the funnel-web spider Atrax robustus

21 January 2018

1 reference

The purification and amino acid sequences of four Tx2 neurotoxins from the venom of the Brazilian 'armed' spider Phoneutria nigriventer (Keys)

21 January 2018

1 reference

Phoneutria nigriventer toxin 1: a novel, state-dependent inhibitor of neuronal sodium channels that interacts with micro conotoxin binding sites

21 January 2018

1 reference

Distinct primary structures of the major peptide toxins from the venom of the spider Macrothele gigas that bind to sites 3 and 4 in the sodium channel.

21 January 2018

1 reference

Function and solution structure of huwentoxin-IV, a potent neuronal tetrodotoxin (TTX)-sensitive sodium channel antagonist from Chinese bird spider Selenocosmia huwena

21 January 2018

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Structure--activity relationships of hainantoxin-IV and structure determination of active and inactive sodium channel blockers

21 January 2018

1 reference

Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes

21 January 2018

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Interactions of polyamines with ion channels

21 January 2018

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PhTx4, a new class of toxins from Phoneutria nigriventer spider venom, inhibits the glutamate uptake in rat brain synaptosomes

21 January 2018

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Inhibition of glutamate uptake by Tx3-4 is dependent on the redox state of cysteine residues

21 January 2018

1 reference

H(+)-gated cation channels: neuronal acid sensors in the NaC/DEG family of ion channels

21 January 2018

1 reference

Ion channels of nociception.

21 January 2018

1 reference

Isolation of a tarantula toxin specific for a class of proton-gated Na+ channels.

21 January 2018

1 reference

Mechanosensitive channels in prokaryotes.

21 January 2018

1 reference

Identification of a peptide toxin from Grammostola spatulata spider venom that blocks cation-selective stretch-activated channels

21 January 2018

1 reference

Voltage gated calcium channels as targets for analgesics.

21 January 2018

1 reference

Animal antimicrobial peptides: an overview

21 January 2018

1 reference

Lycotoxins, antimicrobial peptides from venom of the wolf spider Lycosa carolinensis

21 January 2018

1 reference

Characterisation of antibacterial activity of peptides isolated from the venom of the spider Cupiennius salei (Araneae: Ctenidae).

21 January 2018

1 reference

Cupiennin 1d*: the cytolytic activity depends on the hydrophobic N-terminus and is modulated by the polar C-terminus

21 January 2018

1 reference

De novo sequencing of antimicrobial peptides isolated from the venom glands of the wolf spider Lycosa singoriensis.

21 January 2018

1 reference

The hemolytic activity of six arachnid cationic peptides is affected by the phosphatidylcholine-to-sphingomyelin ratio in lipid bilayers

21 January 2018

1 reference

Antimicrobial and cytolytic peptides of venomous arthropods

21 January 2018

1 reference

Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity.

21 January 2018

1 reference

Cytotoxic effects of arthropod venoms on various cultured cells.

21 January 2018

1 reference

The solution structure of gomesin, an antimicrobial cysteine-rich peptide from the spider

21 January 2018

1 reference

Prophylactic efficacy of topical temporin A and RNAIII-inhibiting peptide in a subcutaneous rat Pouch model of graft infection attributable to staphylococci with intermediate resistance to glycopeptides

21 January 2018

1 reference

Susceptibility of oral bacteria to an antimicrobial decapeptide

21 January 2018

1 reference

Antimicrobial peptides: potential use in skin infections

21 January 2018

1 reference

Isolation, synthesis and pharmacological characterization of delta-palutoxins IT, novel insecticidal toxins from the spider Paracoelotes luctuosus (Amaurobiidae).

21 January 2018

1 reference

Development of a recombinant baculovirus expressing an insect-selective neurotoxin: potential for pest control

21 January 2018

1 reference

Enhanced Bioactivity of Recombinant Baculoviruses Expressing Insect-Specific Spider Toxins in Lepidopteran Crop Pests

21 January 2018

1 reference

An amphibian antimicrobial peptide variant expressed in Nicotiana tabacum confers resistance to phytopathogens.

21 January 2018

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Design, synthesis, and biological evaluation of spider toxin (argiotoxin-636) analogs as NMDA receptor antagonists

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1039/B603083C

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24 July 2017

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