(Q33283622)

25 July 2017

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title

Design of synthetic antibody libraries (English)

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25 July 2017

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Itai Benhar

1

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language of work or name

English

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publication date

1 May 2007

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Expert Opinion on Biological Therapy

25 July 2017

published in

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25 July 2017

volume

7

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25 July 2017

issue

5

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25 July 2017

page(s)

763-779

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Continuous cultures of fused cells secreting antibody of predefined specificity

25 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Assembly of a functional immunoglobulin Fv fragment in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Cloning immunoglobulin variable domains for expression by the polymerase chain reaction

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Selecting and screening recombinant antibody libraries

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Display technologies: application for the discovery of drug and gene delivery agents

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.7.5.763

A large array of human monoclonal antibodies to type 1 human immunodeficiency virus from combinatorial libraries of asymptomatic seropositive individuals

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Phage antibodies: filamentous phage displaying antibody variable domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

By-passing immunization. Human antibodies from V-gene libraries displayed on phage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Making antibodies by phage display technology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Making antibody fragments using phage display libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Human antibodies with sub-nanomolar affinities isolated from a large non-immunized phage display library

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Production of human antibodies using bacteriophage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

By-passing immunisation. Human antibodies from synthetic repertoires of germline VH gene segments rearranged in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Semisynthetic combinatorial antibody libraries: a chemical solution to the diversity problem

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Antigen receptor selection by editing or downregulation of V(D)J recombination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Engineered antibody fragments and the rise of single domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Domain antibodies: proteins for therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Antibody repertoire development in camelids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Nanobodies as novel agents for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

In vitro display technologies reveal novel biopharmaceutics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Selection by phage display of llama conventional V(H) fragments with heavy chain antibody V(H)H properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Oligonucleotide-assisted cleavage and ligation: a novel directional DNA cloning technology to capture cDNAs. Application in the construction of a human immune antibody phage-display library

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Chimpanzee Fab fragments and a derived humanized immunoglobulin G1 antibody that efficiently cross-neutralize dengue type 1 and type 2 viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Guinea pig C3 specific rabbit single chain Fv antibodies from bone marrow, spleen and blood derived phage libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Generation of native bovine mAbs by phage display

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Selection and identification of single domain antibody fragments from camel heavy-chain antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Sheep monoclonal antibody fragments generated using a phage display system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Rapid isolation of IgNAR variable single-domain antibody fragments from a shark synthetic library

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Selective targeting of melanoma and APCs using a recombinant antibody with TCR-like specificity directed toward a melanoma differentiation antigen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

The Remarkable Flexibility of the Human Antibody Repertoire; Isolation of Over One Thousand Different Antibodies to a Single Protein, BLyS

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Broadly cross-reactive HIV-1-neutralizing human monoclonal Fab selected for binding to gp120-CD4-CCR5 complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

The human antibody repertoire specific for rabies virus glycoprotein as selected from immune libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Molecular dissection of the tissue transglutaminase autoantibody response in celiac disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Selection and application of human single chain Fv antibody fragments from a semi-synthetic phage antibody display library with designed CDR3 regions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Engineered turns of a recombinant antibody improve its in vivo folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Design and use of a phage display library. Human antibodies with subnanomolar affinity against a marker of angiogenesis eluted from a two-dimensional gel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Exploiting sequence space: shuffling in vivo formed complementarity determining regions into a master framework

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Recombining germline-derived CDR sequences for creating diverse single-framework antibody libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

A human synthetic combinatorial library of arrayable single-chain antibodies based on shuffling in vivo formed CDRs into general framework regions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

An antibody library for stabilizing and crystallizing membrane proteins - selecting binders to the citrate carrier CitS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Ribosome display for improved biotherapeutic molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Combinatorial protein biochemistry for therapeutics and proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Breaking the affinity ceiling for antibodies and T cell receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

In vitro evolution of a neutralizing human antibody to human immunodeficiency virus type 1 to enhance affinity and broaden strain cross-reactivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Latest technologies for the enhancement of antibody affinity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Construction and diversification of yeast cell surface displayed libraries by yeast mating: application to the affinity maturation of Fab antibody fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

In vitro antibody evolution targeting germline hot spots to increase activity of an anti-CD22 immunotoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Improving antibody affinity by mimicking somatic hypermutation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

In vitro scanning saturation mutagenesis of an antibody binding pocket

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Antibody engineering by parsimonious mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Synthetic antibodies from a four-amino-acid code: a dominant role for tyrosine in antigen recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Anchored periplasmic expression, a versatile technology for the isolation of high-affinity antibodies from Escherichia coli-expressed libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Tailoring in vitro selection for a picomolar affinity human antibody directed against vascular endothelial growth factor receptor 2 for enhanced neutralizing activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Directed evolution of antibody fragments with monovalent femtomolar antigen-binding affinity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Protein affinity maturation in vivo using E. coli mutator cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

CDR walking mutagenesis for the affinity maturation of a potent human anti-HIV-1 antibody into the picomolar range

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Identification of functional and structural amino-acid residues by parsimonious mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Isolation of picomolar affinity anti-c-erbB-2 single-chain Fv by molecular evolution of the complementarity determining regions in the center of the antibody binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Stepwise in vitro affinity maturation of Vitaxin, an alphav beta3-specific humanized mAb.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Antibody humanization using monovalent phage display

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Ultra-potent antibodies against respiratory syncytial virus: effects of binding kinetics and binding valence on viral neutralization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

In vitro selection and affinity maturation of antibodies from a naive combinatorial immunoglobulin library

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Affinity maturation of recombinant antibodies using E. coli mutator cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Affinity maturation of natural antibody using a chain shuffling technique and the expression of recombinant antibodies in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Quantitative analysis of the effect of the mutation frequency on the affinity maturation of single chain Fv antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Picomolar affinity antibodies from a fully synthetic naive library selected and evolved by ribosome display

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Directed evolution of an anti-carcinoembryonic antigen scFv with a 4-day monovalent dissociation half-time at 37 degrees C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Directed in vitro evolution and crystallographic analysis of a peptide-binding single chain antibody fragment (scFv) with low picomolar affinity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Phage-display as a tool for quantifying protein stability determinants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Selection for improved protein stability by phage display.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Improving in vivo folding and stability of a single-chain Fv antibody fragment by loop grafting

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Isolation of monomeric human V(H)s by a phage selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

A phage display approach for rapid antibody humanization: designed combinatorial V gene libraries.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Specificity grafting of human antibody frameworks selected from a phage display library: generation of a highly stable humanized anti-CD22 single-chain Fv fragment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Phage display in pharmaceutical biotechnology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Biotechnological applications of phage and cell display

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Assembly of combinatorial antibody libraries on phage surfaces: the gene III site

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Phage versus phagemid libraries for generation of human monoclonal antibodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Selection of tumor-specific internalizing human antibodies from phage libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Targeted gene delivery to mammalian cells by filamentous bacteriophage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Phage diabody repertoires for selection of large numbers of bispecific antibody fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Isolation of receptor-ligand pairs by capture of long-lived multivalent interaction complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Selectively-infective phage (SIP): a mechanistic dissection of a novel in vivo selection for protein-ligand interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Selectively infective phage (SIP) technology: scope and limitations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Antibodies from phage antibody libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Production and fluorescence-activated cell sorting of Escherichia coli expressing a functional antibody fragment on the external surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Antibody affinity maturation using bacterial surface display.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Development of an optimized expression system for the screening of antibody libraries displayed on the Escherichia coli surface.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Highly efficient selection of phage antibodies mediated by display of antigen as Lpp-OmpA' fusions on live bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Selective phage infection mediated by epitope expression on F pilus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Humanization and epitope mapping of the H23 anti-MUC1 monoclonal antibody reveals a dual epitope specificity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Display of proteins on bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Biotechnological applications for surface-engineered bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Isolation of high-affinity ligand-binding proteins by periplasmic expression with cytometric screening (PECS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Engineering of recombinant antibody fragments to methamphetamine by anchored periplasmic expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Isolation of anti-T cell receptor scFv mutants by yeast surface display

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Flow-cytometric isolation of human antibodies from a nonimmune Saccharomyces cerevisiae surface display library

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Yeast mating for combinatorial Fab library generation and surface display

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Shuffled antibody libraries created by in vivo homologous recombination and yeast surface display

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Exploiting recombination in single bacteria to make large phage antibody libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Affinity maturation of Fab antibody fragments by fluorescent-activated cell sorting of yeast-displayed libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Designing and optimizing library selection strategies for generating high-affinity antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

An in vitro polysome display system for identifying ligands from very large peptide libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Comparison of Escherichia coli and rabbit reticulocyte ribosome display systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Ribosome display: next-generation display technologies for production of antibodies in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Ribosome display of antibodies: expression, specificity and recovery in a eukaryotic system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

RNA-peptide fusions for the in vitro selection of peptides and proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

In-vitro protein evolution by ribosome display and mRNA display

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Man-made cell-like compartments for molecular evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Investigating the target recognition of DNA cytosine-5 methyltransferase HhaI by library selection using in vitro compartmentalisation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Covalent DNA display as a novel tool for directed evolution of proteins in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

DNA display of biologically active proteins for in vitro protein selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

By-passing selection: direct screening for antibody-antigen interactions using protein arrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Antibody arrays in cancer research

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Applications of antibody array platforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Inhibitors of de novo nucleotide biosynthesis as drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Toward optimized antibody microarrays: a comparison of current microarray support materials.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Antibody microarrays: an evaluation of production parameters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Antibody microarrays: current status and key technological advances

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Antibody arrays for high-throughput screening of antibody-antigen interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Microarrays based on affinity-tagged single-chain Fv antibodies: sensitive detection of analyte in complex proteomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Phage display of a cellulose binding domain from Clostridium thermocellum and its application as a tool for antibody engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Versatile protein microarray based on carbohydrate-binding modules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Recombinant antibodies: from the laboratory to the clinic

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Human antibodies from transgenic animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Nonantibody-based recognition: alternative molecules for detection of pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Selection of phage antibodies by binding affinity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

ProteomeBinders: planning a European resource of affinity reagents for analysis of the human proteome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

Yeast polypeptide fusion surface display levels predict thermal stability and soluble secretion efficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.5.763

21 January 2018

Identifiers

DOI

10.1517/14712598.7.5.763

1 reference

25 July 2017

1 reference