(Q33288957)

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Triterpenoids display single agent anti-tumor activity in a transgenic mouse model of chronic lymphocytic leukemia and small B cell lymphoma

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Europe PubMed Central

PubMed publication ID

25 July 2017

Triterpenoids display single agent anti-tumor activity in a transgenic mouse model of chronic lymphocytic leukemia and small B cell lymphoma (English)

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

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1 reference

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chronic lymphocytic leukemia

1 reference

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inferred from title

object named as

Juan M Zapata

10

0 references

Marina Konopleva

2

object named as

Marina Konopleva

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

Michael Andreeff

8

object named as

Michael Andreeff

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

Teresa S McQueen

7

object named as

Teresa McQueen

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

author name string

Christina L Kress

1

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

Vanesa Martínez-García

3

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

Maryla Krajewska

4

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

Sophie Lefebvre

5

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

Marc L Hyer

6

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Europe PubMed Central

PubMed publication ID

25 July 2017

John C Reed

9

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Europe PubMed Central

PubMed publication ID

25 July 2017

language of work or name

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publication date

27 June 2007

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Europe PubMed Central

PubMed publication ID

25 July 2017

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

2

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Europe PubMed Central

PubMed publication ID

25 July 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

e559

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

copyright license

Creative Commons Attribution 4.0 International

27 June 2007

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April 2022 Public Data File from Crossref

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Triterpenoid CDDO-Me blocks the NF-kappaB pathway by direct inhibition of IKKbeta on Cys-179.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891436

21 June 2018

Fludarabine in chronic lymphocytic leukaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891436

21 June 2018

CDDO-Imidazolide inhibits growth and survival of c-Myc-induced mouse B cell and plasma cell neoplasms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891436

21 June 2018

Pharmacological activities of natural triterpenoids and their therapeutic implications.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891436

21 June 2018

A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB-regulated gene products in human leukemic cells

1 reference

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21 June 2018

Purine analogue-based chemotherapy regimens for patients with previously untreated B-chronic lymphocytic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891436

21 June 2018

A novel mechanism of action of methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate: direct permeabilization of the inner mitochondrial membrane to inhibit electron transport and induce apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891436

21 June 2018

2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891436

21 June 2018

2-Cyano-3,12-dioxoolean-1,9-dien-28-oic acid and related compounds inhibit growth of colon cancer cells through peroxisome proliferator-activated receptor gamma-dependent and -independent pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891436

21 June 2018

TNF receptor-associated factor (TRAF) domain and Bcl-2 cooperate to induce small B cell lymphoma/chronic lymphocytic leukemia in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891436

21 June 2018

The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces caspase-dependent and -independent apoptosis in acute myelogenous leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891436

21 June 2018

c-Jun NH2-terminal kinase-mediated up-regulation of death receptor 5 contributes to induction of apoptosis by the novel synthetic triterpenoid methyl-2-cyano-3,12-dioxooleana-1, 9-dien-28-oate in human lung cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891436

21 June 2018

The bortezomib/proteasome inhibitor PS-341 and triterpenoid CDDO-Im induce synergistic anti-multiple myeloma (MM) activity and overcome bortezomib resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891436

21 June 2018

Growth-inhibitory effect of a novel synthetic triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, on ovarian carcinoma cell lines not dependent on peroxisome proliferator-activated receptor-gamma expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891436

21 June 2018

Induction of redox imbalance and apoptosis in multiple myeloma cells by the novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891436

21 June 2018

Activation of peroxisome proliferator-activated receptor gamma by a novel synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces growth arrest and apoptosis in breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891436

21 June 2018

TNF-receptor-associated factors as targets for drug development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891436

21 June 2018

Dysregulation of apoptosis genes in hematopoietic malignancies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891436

21 June 2018

TRAF1: lord without a RING.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891436

21 June 2018

An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891436

21 June 2018

The novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) potently enhances apoptosis induced by tumor necrosis factor in human leukemia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891436

21 June 2018

A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, with potent differentiating, antiproliferative, and anti-inflammatory activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891436

21 June 2018

TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0000559

21 January 2018

A novel dicyanotriterpenoid, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-onitrile, active at picomolar concentrations for inhibition of nitric oxide production

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0000559

21 January 2018

Synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces growth arrest in HER2-overexpressing breast cancer cells

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0000559

21 January 2018

Synthetic triterpenoids cooperate with tumor necrosis factor-related apoptosis-inducing ligand to induce apoptosis of breast cancer cells

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0000559

21 January 2018

Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0000559

21 January 2018

CDDO induces apoptosis via the intrinsic pathway in lymphoid cells.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0000559

21 January 2018

Synthetic triterpenoids activate a pathway for apoptosis in AML cells involving downregulation of FLIP and sensitization to TRAIL.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0000559

21 January 2018

The novel triterpenoid CDDO-Me suppresses MAPK pathways and promotes p38 activation in acute myeloid leukemia cells

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0000559

21 January 2018

Synthetic oleanane and ursane triterpenoids with modified rings A and C: a series of highly active inhibitors of nitric oxide production in mouse macrophages

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0000559

21 January 2018

The novel synthetic triterpenoid, CDDO-imidazolide, inhibits inflammatory response and tumor growth in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891436

31 October 2018

The novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid induces apoptosis of human myeloid leukemia cells by a caspase-8-dependent mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/17593960

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic lymphocytic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17593960

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design and synthesis of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, a novel and highly active inhibitor of nitric oxide production in mouse macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/17593960

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Depletion of intracellular glutathione contributes to JNK-mediated death receptor 5 upregulation and apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me)

1 reference

https://pubmed.ncbi.nlm.nih.gov/17593960

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0000559

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

2007PLoSO...2..559K

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

ResearchGate publication ID

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