(Q33300337)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17895976%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

title

Digital NFATc2 activation per cell transforms graded T cell receptor activation into an all-or-none IL-2 expression (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17895976%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17895976%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Thomas Höfer

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17895976%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Ria Baumgrass

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17895976%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

5

Andreas Radbruch

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17895976%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

author name string

Miriam Podtschaske

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17895976%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Sandra Zwinger

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17895976%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

language of work or name

English

0 references

publication date

26 September 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17895976%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17895976%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

volume

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17895976%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

issue

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17895976%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

page(s)

e935

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17895976%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

8 January 2020

copyright license

start time

26 September 2007

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

FOXP3 controls regulatory T cell function through cooperation with NFAT

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978524

FOXP3 and NFAT: partners in tolerance

21 June 2018

1 reference

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Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978524

Independent roles for IL-2 and GATA-3 in stimulating naive CD4+ T cells to generate a Th2-inducing cytokine environment

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978524

Tolerance, not immunity, crucially depends on IL-2.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978524

Interleukin-2 is essential for CD4+CD25+ regulatory T cell function

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978524

NFAT and NF-kappaB factors-the distant relatives

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978524

The role of cytokines in immunological tolerance: potential for therapy

21 June 2018

1 reference

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A temporal and spatial summation model for T-cell activation: signal integration and antigen decoding

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978524

Multiple cis-acting elements regulate the expression of the early T cell activation antigen CD69.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978524

IL-2 and autoimmune disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978524

Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978524

Binary and graded responses in gene networks

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978524

Defective T cell development and function in calcineurin A beta -deficient mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978524

Transcriptional mechanisms underlying lymphocyte tolerance.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978524

Chromatin remodeling, measured by a novel real-time polymerase chain reaction assay, across the proximal promoter region of the IL-2 gene.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978524

Regulation of interferon-gamma gene expression by nuclear factor of activated T cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978524

Regulation of the immune response by antigen

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978524

Cell signaling can direct either binary or graded transcriptional responses

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978524

The role of NF-AT transcription factors in T cell activation and differentiation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978524

Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978524

Localization dose and time of antigens determine immune reactivity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978524

Kinetics and extent of T cell activation as measured with the calcium signal

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978524

Differential activation of transcription factors induced by Ca2+ response amplitude and duration

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978524

Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978524

A dynamic assembly of diverse transcription factors integrates activation and cell-type information for interleukin 2 gene regulation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978524

Translational control of interleukin 2 messenger RNA as a molecular mechanism of T cell anergy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978524

T cell activation determined by T cell receptor number and tunable thresholds.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978524

Interleukin-2 transcription is regulated in vivo at the level of coordinated binding of both constitutive and regulated factors.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978524

Lymphocyte responses and cytokines

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978524

Novel NFAT sites that mediate activation of the interleukin-2 promoter in response to T-cell receptor stimulation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978524

The architecture of the interleukin-2 promoter: a reflection of T lymphocyte activation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978524

Single cell assay of a transcription factor reveals a threshold in transcription activated by signals emanating from the T-cell antigen receptor.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978524

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978524

Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process

21 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0000935

Fluctuations in transcription factor binding can explain the graded and binary responses observed in inducible gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0000935

Sequential production of IL-2, IFN-gamma and IL-10 by individual staphylococcal enterotoxin B-activated T helper lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0000935

Allosteric regulation of the transcription factor NFAT1 by multiple phosphorylation sites: a mathematical analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0000935

IL-2 secretion by CD4+ T cells in vivo is rapid, transient, and influenced by TCR-specific competition

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0000935

Substitution in position 3 of cyclosporin A abolishes the cyclophilin-mediated gain-of-function mechanism but not immunosuppression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0000935

Analysis and sorting of T cells according to cytokine expression.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978524

T cell fitness determined by signal strength

31 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17895976

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Molecular regulation of interleukin-2 expression by CD28 co-stimulation and anergy

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17895976

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Interleukin-2 expression by a subpopulation of primary T cells is linked to enhanced memory/effector function

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17895976

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0000935

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17895976%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17895976%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

PubMed publication ID

17895976

1 reference