(Q33302249)

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High-throughput screening for fatty acid uptake inhibitors in humanized yeast identifies atypical antipsychotic drugs that cause dyslipidemias

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scholarly article

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Europe PubMed Central

PubMed publication ID

25 July 2017

High-throughput screening for fatty acid uptake inhibitors in humanized yeast identifies atypical antipsychotic drugs that cause dyslipidemias (English)

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Europe PubMed Central

PubMed publication ID

25 July 2017

high-throughput screening

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object named as

Aalap Chokshi

3

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object named as

Paul N Black

2

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author name string

Hong Li

1

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Europe PubMed Central

PubMed publication ID

25 July 2017

Angel Sandoval-Alvarez

4

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Europe PubMed Central

PubMed publication ID

25 July 2017

Ravi Vatsyayan

5

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Europe PubMed Central

PubMed publication ID

25 July 2017

Whitney Sealls

6

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Europe PubMed Central

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25 July 2017

Concetta C DiRusso

7

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Europe PubMed Central

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25 July 2017

publication date

10 October 2007

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Europe PubMed Central

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25 July 2017

Journal of Lipid Research

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Europe PubMed Central

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25 July 2017

49

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Europe PubMed Central

PubMed publication ID

25 July 2017

1

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Europe PubMed Central

PubMed publication ID

25 July 2017

230-244

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Europe PubMed Central

PubMed publication ID

25 July 2017

Fatty acid metabolism and vascular disease

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A free fatty acid tolerance test identifies patients with coronary artery disease among individuals with a low conventional coronary risk profile

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Free fatty acids and type 2 diabetes mellitus

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Diseases of liporegulation: new perspective on obesity and related disorders

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Oxidative capacity, lipotoxicity, and mitochondrial damage in type 2 diabetes

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Non-esterified fatty acids are deleterious for human pancreatic islet function at physiological glucose concentration.

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Fatty acids, lipotoxicity and insulin secretion

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Minireview: Secondary beta-cell failure in type 2 diabetes--a convergence of glucotoxicity and lipotoxicity

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Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes

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Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36.

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The fatty acid transport protein (FATP1) is a very long chain acyl-CoA synthetase

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FATP1 is an insulin-sensitive fatty acid transporter involved in diet-induced obesity

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Increase in membrane uptake of long-chain fatty acids early during preadipocyte differentiation

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Membrane proteins implicated in long-chain fatty acid uptake by mammalian cells: CD36, FATP and FABPm

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21 January 2018

Regulation of putative fatty acid transporters and Acyl-CoA synthetase in liver and adipose tissue in ob/ob mice

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Identification of a functional peroxisome proliferator-responsive element in the murine fatty acid transport protein gene

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Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein

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Involvement of membrane-associated proteins in the acute regulation of cellular fatty acid uptake

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Protein-mediated fatty acid uptake: novel insights from in vivo models

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Transmembrane movement of exogenous long-chain fatty acids: proteins, enzymes, and vectorial esterification

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21 January 2018

Vectorial acylation in Saccharomyces cerevisiae. Fat1p and fatty acyl-CoA synthetase are interacting components of a fatty acid import complex.

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21 January 2018

Comparative biochemical studies of the murine fatty acid transport proteins (FATP) expressed in yeast

1 reference

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21 January 2018

Fatty acid transport protein 1 and long-chain acyl coenzyme A synthetase 1 interact in adipocytes

1 reference

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21 January 2018

Disruption of the Saccharomyces cerevisiae homologue to the murine fatty acid transport protein impairs uptake and growth on long-chain fatty acids

1 reference

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21 January 2018

Transport of fatty acids across membranes by the diffusion mechanism.

1 reference

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A model for fatty acid transport into the brain.

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pH gradients across phospholipid membranes caused by fast flip-flop of un-ionized fatty acids

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Fatty acids enter cells by simple diffusion

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Changes of intrinsic membrane potentials induced by flip-flop of long-chain fatty acids

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A live-cell high-throughput screening assay for identification of fatty acid uptake inhibitors.

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Arterial stiffness and stroke in hypertension: therapeutic implications for stroke prevention

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Murine FATP alleviates growth and biochemical deficiencies of yeast fat1Delta strains.

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Chromatin remodeling by transcriptional activation domains in a yeast episome.

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21 January 2018

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

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The Acyl-CoA synthetases encoded within FAA1 and FAA4 in Saccharomyces cerevisiae function as components of the fatty acid transport system linking import, activation, and intracellular Utilization.

1 reference

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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

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Confirmation of primary active substances from high throughput screening of chemical and biological populations: a statistical approach and practical considerations

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GFAP phosphorylation studied in digitonin-permeabilized astrocytes: standardization of conditions.

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Optimizing Caco-2 cell monolayers to increase throughput in drug intestinal absorption analysis

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A novel fluorescent fatty acid, 5-methyl-BDY-3-dodecanoic acid, is a potential probe in lipid transport studies by incorporating selectively to lipid classes of BHK cells

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Role of albumin as a fatty acid carrier for biosynthesis of lens lipids

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The metabolic effects of antipsychotic medications

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The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

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Real-time quantification of fatty acid uptake using a novel fluorescence assay

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Identifiers

10.1194/JLR.D700015-JLR200

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

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