(Q33308713)

25 July 2017

title

An anticancer C-Kit kinase inhibitor is reengineered to make it more active and less cardiotoxic. (English)

1 reference

25 July 2017

Allen Samarel

17

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James A. Bankson

object named as

James A Bankson

15

0 references

Anil K. Sood

19

object named as

Anil K Sood

1 reference

25 July 2017

Ariel Fernández

1

1 reference

25 July 2017

Angela Sanguino

2

1 reference

25 July 2017

Zhenghong Peng

3

1 reference

25 July 2017

Eylem Ozturk

4

1 reference

25 July 2017

Jianping Chen

5

1 reference

25 July 2017

Alejandro Crespo

6

1 reference

25 July 2017

Sarah Wulf

7

1 reference

25 July 2017

Aleksander Shavrin

8

1 reference

25 July 2017

Chaoping Qin

9

1 reference

25 July 2017

Jianpeng Ma

10

1 reference

25 July 2017

Jonathan Trent

11

1 reference

25 July 2017

Yvonne Lin

12

1 reference

25 July 2017

Hee-Dong Han

13

1 reference

25 July 2017

Lingegowda S Mangala

14

1 reference

25 July 2017

Juri Gelovani

16

1 reference

25 July 2017

William Bornmann

18

1 reference

25 July 2017

Gabriel Lopez-Berestein

20

1 reference

25 July 2017

language of work or name

English

0 references

publication date

1 December 2007

1 reference

Journal of Clinical Investigation

25 July 2017

published in

1 reference

25 July 2017

volume

117

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25 July 2017

issue

12

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25 July 2017

page(s)

4044-4054

1 reference

Molecular basis for specificity in the druggable kinome: sequence-based analysis

25 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2104494

Cardiotoxicity of the cancer therapeutic agent imatinib mesylate.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2104494

Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2104494

Establishment of a mouse gastrointestinal stromal tumour model and evaluation of response to imatinib by small animal positron emission tomography

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2104494

Features of selective kinase inhibitors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2104494

Tyrosine kinase inhibitors and the dawn of molecular cancer therapeutics

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2104494

A small molecule-kinase interaction map for clinical kinase inhibitors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2104494

STRESS signaling pathways that modulate cardiac myocyte apoptosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2104494

Molecularly targeted therapy: have the floodgates opened?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2104494

Chronic myelogenous leukemia as a paradigm of early cancer and possible curative strategies

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2104494

Issues and progress with protein kinase inhibitors for cancer treatment

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2104494

Insufficiently dehydrated hydrogen bonds as determinants of protein interactions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2104494

The GIST of targeted cancer therapy: a tumor (gastrointestinal stromal tumor), a mutated gene (c-kit), and a molecular inhibitor (STI571).

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2104494

Phosphorylation and structure-based functional studies reveal a positive and a negative role for the activation loop of the c-Abl tyrosine kinase.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2104494

STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2104494

Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2104494

Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2104494

Inhibition of the ABL kinase activity blocks the proliferation of BCR/ABL+ leukemic cells and induces apoptosis.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2104494

Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2104494

Tyrosine kinase inhibition: an approach to drug development

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2104494

Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2104494

Contractile activity modulates myosin heavy chain-beta expression in neonatal rat heart cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2104494

Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2104494

The c-kit tyrosine kinase inhibitor STI571 for colorectal cancer therapy.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2104494

A new model of congestive heart failure in the mouse due to chronic volume overload

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2104494

Imatinib does not induce cardiac left ventricular failure in gastrointestinal stromal tumours patients: Analyis of EORTC-ISG-AGITG study 62005

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2104494

Molecular remissions induced by liposomal-encapsulated all-trans retinoic acid in newly diagnosed acute promyelocytic leukemia

31 October 2018

1 reference

12 December 2020

Clinical use of tyrosine kinase inhibitors: therapy for chronic myelogenous leukemia and other cancers

1 reference

12 December 2020

Solvent effects on protein motion and protein effects on solvent motion. Dynamics of the active site region of lysozyme

1 reference

12 December 2020

Pharmaceutical research in molecular oncology

1 reference

12 December 2020

Characterization of pp60c-src Tyrosine Kinase Activities Using a Continuous Assay: Autoactivation of the Enzyme Is an Intermolecular Autophosphorylation Process

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI32373

1 reference

25 July 2017

1 reference

25 July 2017

1 reference