(Q33313620)

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Development and implementation of a miniaturized high-throughput time-resolved fluorescence energy transfer assay to identify small molecule inhibitors of polo-like kinase 1.

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scholarly article

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Europe PubMed Central

PubMed publication ID

25 July 2017

Development and implementation of a miniaturized high-throughput time-resolved fluorescence energy transfer assay to identify small molecule inhibitors of polo-like kinase 1. (English)

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

4

object named as

John S Lazo

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

Elizabeth R Sharlow

1

object named as

Elizabeth R Sharlow

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

Stephanie Leimgruber

2

object named as

Stephanie Leimgruber

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

3

object named as

Tong Ying Shun

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

publication date

1 December 2007

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

Assay and Drug Development Technologies

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

723-735

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of RNA silencing of polo-like kinase-1 (PLK1) on apoptosis and spindle formation in human cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteomic screen defines the Polo-box domain interactome and identifies Rock2 as a Plk1 substrate.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell cycle analysis and chromosomal localization of human Plk1, a putative homologue of the mitotic kinases Drosophila polo and Saccharomyces cerevisiae Cdc5.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small interfering RNA-mediated Polo-like kinase 1 depletion preferentially reduces the survival of p53-defective, oncogenic transformed cells and inhibits tumor growth in animals

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting polo-like kinase 1 for cancer therapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of Polo-like kinase 1 is a common and early event in pancreatic cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development and optimization of high-throughput in vitro protein phosphatase screening assays

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-throughput screening with immobilized metal ion affinity-based fluorescence polarization detection, a homogeneous assay for protein kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flying under the radar: the new wave of BCR-ABL inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic significance of polo-like kinase (PLK) expression in squamous cell carcinomas of the head and neck

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of the catalytic domain of human polo-like kinase 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PICH, a centromere-associated SNF2 family ATPase, is regulated by Plk1 and required for the spindle checkpoint

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plk1 promotes nuclear translocation of human Cdc25C during prophase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human papillomavirus type 16 E6 and E7 cause polyploidy in human keratinocytes and up-regulation of G2-M-phase proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

siRNA targeting PLK-1 induces apoptosis of synoviocytes in rheumatoid arthritis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in the Plk gene lead to instability of Plk protein in human tumour cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor inhibition by genomically integrated inducible RNAi-cassettes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polo-like kinases (Plks) and cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The identification and characterization of the marine natural product scytonemin as a novel antiproliferative pharmacophore

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polo-like kinases and the orchestration of cell division

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer inhibition in nude mice after systemic application of U6 promoter-driven short hairpin RNAs against PLK1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dysregulation of the polo-like kinase pathway in CD4+ T cells is characteristic of pathogenic simian immunodeficiency virus infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PLK (polo-like kinase), a new prognostic marker for oropharyngeal carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Readout technologies for highly miniaturized kinase assays applicable to high-throughput screening in a 1536-well format.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polo-like kinase isoforms in breast cancer: expression patterns and prognostic implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progress in the discovery of polo-like kinase inhibitors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polo-like kinase 1 is overexpressed in prostate cancer and linked to higher tumor grades

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polo-like kinase 1 facilitates chromosome alignment during prometaphase through BubR1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of a fluorescence polarization bead-based coupled assay to target different activity/conformation states of a protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of a fluorescence polarization AKT serine/threonine kinase assay using an immobilized metal ion affinity-based technology

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic significance of polo-like kinase (PLK) expression in non-small cell lung cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Downregulation of human polo-like kinase activity by antisense oligonucleotides induces growth inhibition in cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Malignant transformation of mammalian cells initiated by constitutive expression of the polo-like kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polo-like kinase 1 as a target for human cytomegalovirus pp65 lower matrix protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal polo-like kinase in Alzheimer disease indicates cell cycle changes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immobilized metal ion affinity-based fluorescence polarization (IMAP): advances in kinase screening

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A homogeneous fluorescence polarization assay adaptable for a range of protein serine/threonine and tyrosine kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/18181689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1089/ADT.2007.102

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

PMC publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

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