(Q33323615)

25 July 2017

title

Simulation-based cheminformatic analysis of organelle-targeted molecules: lysosomotropic monobasic amines (English)

1 reference

25 July 2017

Xinyuan Zhang

1

1 reference

25 July 2017

Nan Zheng

series ordinal

2

1 reference

25 July 2017

Gus R Rosania

series ordinal

3

1 reference

25 July 2017

publication date

13 March 2008

1 reference

Journal of Computer - Aided Molecular Design

25 July 2017

published in

1 reference

25 July 2017

volume

22

1 reference

25 July 2017

issue

9

1 reference

25 July 2017

page(s)

629-645

1 reference

Prospecting for Live Cell BioImaging Probes With Cheminformatic Assisted Image Arrays (CAIA)

25 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

Resveratrol inhibits tumor growth of human neuroblastoma and mediates apoptosis by directly targeting mitochondria

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

Rapid doxorubicin efflux from the nucleus of drug-resistant cancer cells following extracellular drug clearance

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

Cell-based fluorescence assay for evaluation of new-drugs potential for phospholipidosis in an early stage of drug development

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

Gene therapy of the other genome: the challenges of treating mitochondrial DNA defects

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

A new approach for enhancing differential selectivity of drugs to cancer cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

How many drug targets are there?

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

Lysosomal sequestration of amine-containing drugs: analysis and therapeutic implications

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

Masked oral prodrugs of toll-like receptor 7 agonists: a new approach for the treatment of infectious disease.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

Therapeutic peptides: Targeting the mitochondrion to modulate apoptosis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

The role of the VPS4A-exosome pathway in the intrinsic egress route of a DNA-binding anticancer drug

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

A novel assay reveals that weakly basic model compounds concentrate in lysosomes to an extent greater than pH-partitioning theory would predict

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

N-substituted 4-aminobenzamides (procainamide analogs): an assessment of multiple cellular effects concerning ion trapping

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

System dynamics of subcellular transport

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

Cell culture-based models for intestinal permeability: a critique

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

Weak base permeability characteristics influence the intracellular sequestration site in the multidrug-resistant human leukemic cell line HL-60.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

Use of physicochemical calculation of pKa and CLogP to predict phospholipidosis-inducing potential: a case study with structurally related piperazines

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

Massive cell vacuolization induced by organic amines such as procainamide.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

A cell fractionation approach for the quantitative analysis of subcellular drug disposition

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

Chemoinformatic analysis of a supertargeted combinatorial library of styryl molecules.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

Subcellular localization of Toll-like receptor 3 in human dendritic cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

Supertargeted chemistry: identifying relationships between molecular structures and their sub-cellular distribution

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

Combinatorial approach to organelle-targeted fluorescent library based on the styryl scaffold

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

3-Aminopropanal, formed during cerebral ischaemia, is a potent lysosomotropic neurotoxin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

Intracellular distribution of psychotropic drugs in the grey and white matter of the brain: the role of lysosomal trapping

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

Drug-induced phospholipidosis: are there functional consequences?

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

Mitochondriotropic cationic vesicles: a strategy towards mitochondrial gene therapy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

MDCK (Madin-Darby canine kidney) cells: A tool for membrane permeability screening

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

Primary cell cultures from murine kidney and heart differ in endosomal pH.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

Vesicular anthracycline accumulation in doxorubicin-selected U-937 cells: participation of lysosomes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

Physiochemical and physiological mechanisms for the effects of food on drug absorption: the role of lipids and pH.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

Imaging in five dimensions: time-dependent membrane potentials in individual mitochondria

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

Intracellular pH and the control of multidrug resistance

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

Cytoplasmic vacuolation of mouse peritoneal macrophages and the uptake into lysosomes of weakly basic substances

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

Evidence for lysosomotropic action of desipramine in cultured human fibroblasts

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

Commentary. Lysosomotropic agents

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

Selective lysosomal uptake and accumulation of the beta-adrenergic antagonist propranolol in cultured and isolated cell systems

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

Proton pump-generated electrochemical gradients in rat liver multivesicular bodies. Quantitation and effects of chloride

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

A chloroquine-resistant Swiss 3T3 cell line with a defect in late endocytic acidification

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

Lysosomotropic behavior of adrenergic antagonists in interactions with human neutrophils

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

Assay of vacuolar pH in yeast and identification of acidification-defective mutants

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

Drug-induced lysosomal disorders in laboratory animals: new substances acting on lysosomes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

Perhexiline maleate-induced cirrhosis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

A predictive model for the selective accumulation of chemicals in tumor cells.

28 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS10822-008-9194-7

Factors determining the plasma-membrane potential of lymphocytes

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS10822-008-9194-7

Mitochondriotropics: a review of their mode of action, and their applications for drug and DNA delivery to mammalian mitochondria

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

A cell-based molecular transport simulator for pharmacokinetic prediction and cheminformatic exploration.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

Role of Toll-like receptors in infection and immunity: clinical implications

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

Quantitation of the lysosomotropic character of cationic amphiphilic drugs using the fluorescent basic amine Red DND-99.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

DQAsome-mediated delivery of plasmid DNA toward mitochondria in living cells

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

MECHANISM OF DRUG-INDUCED VACUOLIZATION IN TISSUE CULTURE.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

Increased expression of cathepsin D in retrosplenial cortex of MK-801-treated rats

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

In vivo and in vitro reversibility of chlorphentermine-induced phospholipidosis in rat alveolar macrophages

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516532

Effects of lysosomotropic monoamines, diamines, amino alcohols, and other amino compounds on protein degradation and protein synthesis in isolated rat hepatocytes

31 October 2018

1 reference

12 December 2020

Drug liposome partitioning as a tool for the prediction of human passive intestinal absorption

1 reference

12 December 2020

Lysosomal alterations in cultured macrophages exposed to anorexigenic and psychotropic drugs

1 reference

12 December 2020

1 reference

12 December 2020

Evidence for lysosomotropism of memantine in cultured human cells: cellular kinetics and effects of memantine on phospholipid content and composition, membrane fluidity and beta-adrenergic transmission

1 reference

12 December 2020

Contribution of lysosomes to the subcellular distribution of basic drugs in the rat liver

1 reference

12 December 2020

Effects of cyproheptadine on the rat yolk sac membrane and embryonic development in vitro

1 reference

12 December 2020

Lysosomes contribute to anomalous pharmacokinetic behavior of melanocortin-4 receptor agonists

1 reference

12 December 2020

Uptake and intracellular distribution of neutral red in cultured fibroblasts

1 reference

12 December 2020

Fluoxetine hydrochloride (Prozac)-induced pulmonary disease

1 reference

12 December 2020

Uptake of imipramine in rat liver lysosomes in vitro and its inhibition by basic drugs

1 reference

12 December 2020

Effects of lysosomotropic detergents on the human malarial parasite Plasmodium falciparum in in vitro culture

1 reference

12 December 2020

10.1007/S10822-008-9194-7

Identifiers

DOI

1 reference

25 July 2017

DBLP publication ID

journals/jcamd/ZhangZR08

1 reference

DBLP Dataset 2021-01-02

28 January 2021

1 reference

25 July 2017

1 reference