(Q33354161)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18648664%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

title

Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18648664%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

main subject

hepatocellular carcinoma

1 reference

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18648664%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Irene Oi-lin Ng

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18648664%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

author name string

Carmen Chak-Lui Wong

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18648664%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Chun-Ming Wong

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18648664%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Frankie Chi-Fat Ko

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18648664%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Lo-Kong Chan

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18648664%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Yick-Pang Ching

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18648664%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

language of work or name

English

0 references

publication date

23 July 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18648664%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18648664%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

volume

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18648664%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18648664%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

page(s)

e2779

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18648664%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

11 January 2020

copyright license

start time

23 July 2008

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma

1 reference

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DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms

21 June 2018

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21 June 2018

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21 June 2018

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The forces behind cell movement

21 June 2018

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Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities

21 June 2018

1 reference

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DLC-1, a GTPase-activating protein for Rho, is associated with cell proliferation, morphology, and migration in human hepatocellular carcinoma

21 June 2018

1 reference

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The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1

21 June 2018

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Endosomes generate localized Rho-ROCK-MLC2-based contractile signals via Endo180 to promote adhesion disassembly

21 June 2018

1 reference

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Expression profile of the tumor suppressor genes DLC-1 and DLC-2 in solid tumors

21 June 2018

1 reference

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Interaction of deleted in liver cancer 1 with tensin2 in caveolae and implications in tumor suppression

21 June 2018

1 reference

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The major 8p22 tumor suppressor DLC1 is frequently silenced by methylation in both endemic and sporadic nasopharyngeal, esophageal, and cervical carcinomas, and inhibits tumor cell colony formation.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2464714

Aberrant methylation and deacetylation of deleted in liver cancer-1 gene in prostate cancer: potential clinical applications

21 June 2018

1 reference

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Rho GTPase-activating protein deleted in liver cancer suppresses cell proliferation and invasion in hepatocellular carcinoma.

21 June 2018

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p190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin signalling

21 June 2018

1 reference

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Intrathecal administration of Y-27632, a specific rho-associated kinase inhibitor, for rat neoplastic meningitis

21 June 2018

1 reference

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Regulation of cancer cell motility through actin reorganization

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2464714

The RhoGAP protein DLC-1 functions as a metastasis suppressor in breast cancer cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2464714

Regulation of PTEN by Rho small GTPases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2464714

Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion

21 June 2018

1 reference

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Identification of ATF-3, caveolin-1, DLC-1, and NM23-H2 as putative antitumorigenic, progesterone-regulated genes for ovarian cancer cells by gene profiling

21 June 2018

1 reference

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Characterization of a novel GTPase-activating protein associated with focal adhesions and the actin cytoskeleton

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2464714

A PLCdelta1-binding protein, p122RhoGAP, is localized in focal adhesions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2464714

DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2464714

Restoration of DLC-1 gene expression induces apoptosis and inhibits both cell growth and tumorigenicity in human hepatocellular carcinoma cells

21 June 2018

1 reference

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Genetic and epigenetic alterations of DLC-1 gene in hepatocellular carcinoma

21 June 2018

1 reference

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Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis

21 June 2018

1 reference

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Rocks: multifunctional kinases in cell behaviour

21 June 2018

1 reference

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DLC-1 gene inhibits human breast cancer cell growth and in vivo tumorigenicity

21 June 2018

1 reference

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Regulation of substrate adhesion dynamics during cell motility

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2464714

Characterization of RhoA-binding kinase ROKalpha implication of the pleckstrin homology domain in ROKalpha function using region-specific antibodies

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2464714

Activation of Rhoa and ROCK are essential for detachment of migrating leukocytes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2464714

RhoA is required for monocyte tail retraction during transendothelial migration

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2464714

Rho-kinase--mediated contraction of isolated stress fibers

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2464714

Inhibition of intrahepatic metastasis of human hepatocellular carcinoma by Rho-associated protein kinase inhibitor Y-27632.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2464714

Distinct roles of ROCK (Rho-kinase) and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibers and focal adhesions in 3T3 fibroblasts.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2464714

Rho-kinase inhibitor retards migration and in vivo dissemination of human prostate cancer cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2464714

The COOH terminus of Rho-kinase negatively regulates rho-kinase activity.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2464714

Cell motility mediated by rho and rho-associated protein kinase plays a critical role in intrahepatic metastasis of human hepatocellular carcinoma

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2464714

An essential part for Rho-associated kinase in the transcellular invasion of tumor cells.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2464714

Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2464714

Rho GTPases and the actin cytoskeleton

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2464714

p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2464714

The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2464714

Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2464714

Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2464714

Signal transduction through small GTPases—A tale of two GAPs

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2464714

Promoter hypermethylation of DLC-1, a candidate tumor suppressor gene, in several common human cancers

21 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002779

Analysis of DLC-1 expression in human breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002779

Rho-kinase contributes to diphosphorylation of myosin II regulatory light chain in nonmuscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002779

Efficacy and safety of fasudil in patients with stable angina: a double-blind, placebo-controlled, phase 2 trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002779

[Relationship between DLC-1 expressions and metastasis in hepatocellular carcinoma].

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2464714

Small GTP-binding protein Rho stimulates the actomyosin system, leading to invasion of tumor cells

31 October 2018

1 reference

12 December 2020

Overexpression of small GTP-binding protein RhoA promotes invasion of tumor cells

1 reference

12 December 2020

ROCK1 phosphorylates and activates zipper-interacting protein kinase

1 reference

12 December 2020

DLC-1 is deleted in primary hepatocellular carcinoma and exerts inhibitory effects on the proliferation of hepatoma cell lines with deleted DLC-1

1 reference

12 December 2020

Significant association of Rho/ROCK pathway with invasion and metastasis of bladder cancer

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0002779

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18648664%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18648664%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

PubMed publication ID

18648664

1 reference