(Q33364520)

26 July 2017

PEGylated helper-dependent adenoviral vectors: highly efficient vectors with an enhanced safety profile (English)

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26 July 2017

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L Pastore

7

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Gabriele Toietta

object named as

G Toietta

5

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Vincenzo Cerullo

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V Cerullo

4

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Maria A Croyle

1

object named as

M A Croyle

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26 July 2017

H T Le

2

1 reference

PubMed ID

15647765

26 July 2017

K D Linse

3

1 reference

PubMed ID

15647765

26 July 2017

A Beaudet

6

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26 July 2017

1 April 2005

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26 July 2017

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26 July 2017

12

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26 July 2017

579-587

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26 July 2017

7

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https://scigraph.springernature.com/pub.10.1038/sj.gt.3302441

26 July 2017

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cites work

Adenovirus-mediated in vivo gene transfer and expression in normal rat liver

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302441

Gene transfer into the liver of nonhuman primates with E1-deleted recombinant adenoviral vectors: safety of readministration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302441

Modulation of the inflammatory properties and hepatotoxicity of recombinant adenovirus vectors by the viral E4 gene products.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302441

Lethal toxicity, severe endothelial injury, and a threshold effect with high doses of an adenoviral vector in baboons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302441

Adenoviral gene therapy leads to rapid induction of multiple chemokines and acute neutrophil-dependent hepatic injury in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302441

Acute cytokine response to systemic adenoviral vectors in mice is mediated by dendritic cells and macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302441

Molecular basis of the inflammatory response to adenovirus vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302441

Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302441

Activation of innate immunity in nonhuman primates following intraportal administration of adenoviral vectors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302441

High doses of a helper-dependent adenoviral vector yield supraphysiological levels of alpha1-antitrypsin with negligible toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302441

Lifetime correction of genetic deficiency in mice with a single injection of helper-dependent adenoviral vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302441

Long-term stable correction of low-density lipoprotein receptor-deficient mice with a helper-dependent adenoviral vector expressing the very low-density lipoprotein receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302441

Selective depletion or blockade of Kupffer cells leads to enhanced and prolonged hepatic transgene expression using high-capacity adenoviral vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302441

Acute toxicity after high-dose systemic injection of helper-dependent adenoviral vectors into nonhuman primates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302441

Helper-dependent adenovirus vectors elicit intact innate but attenuated adaptive host immune responses in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302441

Use of helper-dependent adenoviral vectors of alternative serotypes permits repeat vector administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302441

PEGylation of E1-deleted adenovirus vectors allows significant gene expression on readministration to liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302441

The role of capsid-endothelial interactions in the innate immune response to adenovirus vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302441

Effect of pegylation on pharmaceuticals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302441

Endogenous mediators in emergency department patients with presumed sepsis: are levels associated with progression to severe sepsis and death?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302441

Intravenous administration of replication-incompetent adenovirus to rhesus monkeys induces thrombocytopenia by increasing in vivo platelet clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302441

21 January 2018

The origin of pegnology

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302441

Prolonged transgene expression mediated by a helper-dependent adenoviral vector (hdAd) in the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302441

Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302441

A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302441

PEGylation of adenovirus with retention of infectivity and protection from neutralizing antibody in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302441

Use of a liver-specific promoter reduces immune response to the transgene in adenoviral vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302441

7 January 2021

Cytotoxic T-lymphocyte target proteins and their major histocompatibility complex class I restriction in response to adenovirus vectors delivered to mouse liver.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302441

7 January 2021

Toxicity associated with repeated administration of first-generation adenovirus vectors does not occur with a helper-dependent vector.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302441

7 January 2021

A method for the estimation of polyethylene glycol in plasma protein fractions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302441

7 January 2021

Immune tolerance induced by polyethylene glycol-conjugate of protein antigen: clonal deletion of antigen-specific Th-cells in the thymus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302441

7 January 2021

Extended blood half-life of monomethoxypolyethylene glycol-conjugated hen lysozyme is a key parameter controlling immunological tolerogenicity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302441

7 January 2021

Helper-dependent adenoviral vectors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302441

7 January 2021

The polypeptides of adenovirus. I. Evidence for multiple protein components in the virion and a comparison of types 2, 7A, and 12

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302441

7 January 2021

Identifiers

DOI

10.1038/SJ.GT.3302441

1 reference

26 July 2017

1 reference

PubMed ID

15647765