(Q33388221)

26 July 2017

Hypermutable non-synonymous sites are under stronger negative selection (English)

1 reference

26 July 2017

corrigendum / erratum

0 references

3

Fyodor A Kondrashov

1 reference

26 July 2017

Steffen Schmidt

1

1 reference

26 July 2017

Anna Gerasimova

2

1 reference

26 July 2017

Ivan A Adzhubei

4

1 reference

26 July 2017

Alexey S Kondrashov

5

1 reference

26 July 2017

Shamil Sunyaev

6

1 reference

26 July 2017

28 November 2008

1 reference

26 July 2017

1 reference

26 July 2017

4

1 reference

26 July 2017

e1000281

1 reference

26 July 2017

11

1 reference

Creative Commons Attribution 4.0 International

26 July 2017

start time

28 November 2008

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Assessing the evolutionary impact of amino acid mutations in the human genome

1 reference

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Human genome ultraconserved elements are ultraselected

21 June 2018

1 reference

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Widely distributed noncoding purifying selection in the human genome

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583910

Most rare missense alleles are deleterious in humans: implications for complex disease and association studies

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583910

The strength of selection on ultraconserved elements in the human genome

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583910

Evolutionary anatomies of positions and types of disease-associated and neutral amino acid mutations in the human genome

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583910

Functional variation and evolution of non-coding DNA.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583910

Higher intensity of purifying selection on >90% of the human genes revealed by the intrinsic replacement mutation rates

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583910

Predicting the effects of amino acid substitutions on protein function

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583910

The distribution of fitness effects of new deleterious amino acid mutations in humans

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583910

Hearing silence: non-neutral evolution at synonymous sites in mammals

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583910

Selection in favor of nucleotides G and C diversifies evolution rates and levels of polymorphism at mammalian synonymous sites

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583910

Natural selection on protein-coding genes in the human genome

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583910

Initial sequence of the chimpanzee genome and comparison with the human genome

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583910

The scale of mutational variation in the murid genome

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583910

Small fitness effect of mutations in highly conserved non-coding regions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583910

Whole-genome patterns of common DNA variation in three human populations

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583910

Finishing the euchromatic sequence of the human genome

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583910

Bayesian Markov chain Monte Carlo sequence analysis reveals varying neutral substitution patterns in mammalian evolution

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583910

Ultraconserved Elements in the Human Genome

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583910

Theoretical analysis of mutation hotspots and their DNA sequence context specificity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583910

Neutral Substitutions Occur at a Faster Rate in Exons Than in Noncoding DNA in Primate Genomes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583910

Selection on Human Genes as Revealed by Comparisons to Chimpanzee cDNA

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583910

The UCSC Genome Browser Database

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583910

Genomewide comparison of DNA sequences between humans and chimpanzees

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583910

Prediction of deleterious human alleles

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583910

dbSNP: the NCBI database of genetic variation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583910

Estimate of the mutation rate per nucleotide in humans

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583910

Mutation rates differ among regions of the mammalian genome

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583910

Conserved noncoding sequences are selectively constrained and not mutation cold spots

21 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000281

Distribution of the strength of selection against amino acid replacements in human proteins

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19043566

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Patterns in spontaneous mutation revealed by human-baboon sequence comparison

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19043566

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Direct estimates of human per nucleotide mutation rates at 20 loci causing Mendelian diseases

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19043566

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PGEN.1000281

1 reference

26 July 2017

1 reference

26 July 2017

1 reference