(Q33392476)

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Phase II trial of the ribonucleotide reductase inhibitor 3-aminopyridine-2-carboxaldehydethiosemicarbazone plus gemcitabine in patients with advanced biliary tract cancer

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Europe PubMed Central

PubMed publication ID

26 July 2017

Phase II trial of the ribonucleotide reductase inhibitor 3-aminopyridine-2-carboxaldehydethiosemicarbazone plus gemcitabine in patients with advanced biliary tract cancer (English)

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Europe PubMed Central

PubMed publication ID

26 July 2017

phase II clinical trial

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1 reference

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inferred from title

3

object named as

Joseph A Sparano

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

author name string

Allyson J Ocean

1

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Europe PubMed Central

PubMed publication ID

26 July 2017

Paul Christos

2

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Europe PubMed Central

PubMed publication ID

26 July 2017

Dan Matulich

4

1 reference

Europe PubMed Central

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26 July 2017

Andreas Kaubish

5

1 reference

Europe PubMed Central

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26 July 2017

Abby Siegel

6

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Europe PubMed Central

PubMed publication ID

26 July 2017

Max Sung

7

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Maureen M Ward

8

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Nancy Hamel

9

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Europe PubMed Central

PubMed publication ID

26 July 2017

Igor Espinoza-Delgado

10

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Europe PubMed Central

PubMed publication ID

26 July 2017

Yun Yen

11

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Europe PubMed Central

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26 July 2017

Maureen E Lane

12

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Europe PubMed Central

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26 July 2017

publication date

28 October 2010

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Europe PubMed Central

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26 July 2017

Cancer Chemotherapy and Pharmacology

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Europe PubMed Central

PubMed publication ID

26 July 2017

68

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Europe PubMed Central

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26 July 2017

2

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Europe PubMed Central

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26 July 2017

379-388

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Europe PubMed Central

PubMed publication ID

26 July 2017

A phase I study of prolonged infusion of triapine in combination with fixed dose rate gemcitabine in patients with advanced solid tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446256

21 June 2018

Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446256

21 June 2018

Phase I trial of pelvic radiation, weekly cisplatin, and 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) for locally advanced cervical cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446256

21 June 2018

Gemcitabine alone or in combination with cisplatin in patients with advanced or metastatic cholangiocarcinomas or other biliary tract tumours: a multicentre randomised phase II study - The UK ABC-01 Study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446256

21 June 2018

Cancer statistics, 2009

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446256

21 June 2018

Implication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446256

21 June 2018

Increasing incidence of intrahepatic cholangiocarcinoma and its relationship to chronic viral hepatitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446256

21 June 2018

Impairment of the DNA repair and growth arrest pathways by p53R2 silencing enhances DNA damage-induced apoptosis in a p53-dependent manner in prostate cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446256

21 June 2018

A phase 2 consortium (P2C) trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) for advanced adenocarcinoma of the pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446256

21 June 2018

A Phase II study of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) and gemcitabine in advanced pancreatic carcinoma. A trial of the Princess Margaret hospital Phase II consortium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446256

21 June 2018

Single-agent gemcitabine in the treatment of advanced biliary tract cancers: a phase II study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446256

21 June 2018

A Phase II trial of fixed dose rate gemcitabine in patients with advanced biliary tree carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446256

21 June 2018

Clonorchiasis and cholangiocarcinoma: etiologic relationship and imaging diagnosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446256

21 June 2018

p53R2-dependent pathway for DNA synthesis in a p53-regulated cell cycle checkpoint

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446256

21 June 2018

Triapine (3-aminopyridine-2-carboxaldehyde- thiosemicarbazone): A potent inhibitor of ribonucleotide reductase activity with broad spectrum antitumor activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446256

21 June 2018

New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446256

21 June 2018

Biliary tract cancers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446256

21 June 2018

Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): an inhibitor of ribonucleotide reductase with antineoplastic activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446256

21 June 2018

Effects of perturbations of pools of deoxyribonucleoside triphosphates on expression of ribonucleotide reductase, a G1/S transition state enzyme, in p53-mutated cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446256

21 June 2018

Quantification of ribonucleotide reductase expression in wild-type and hydroxyurea-resistant cell lines employing in situ reverse transcriptase polymerase chain reaction and a computerized image analysis system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446256

21 June 2018

The mammalian ribonucleotide reductase R2 component cooperates with a variety of oncogenes in mechanisms of cellular transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446256

21 June 2018

Ribonucleotide reductase and cell proliferation. I. Variations of ribonucleotide reductase activity with tumor growth rate in a series of rat hepatomas.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446256

21 June 2018

Weekly gemcitabine for the treatment of biliary tract and gallbladder cancer

1 reference

https://api.crossref.org/works/10.1007%2FS00280-010-1481-Z

21 January 2018

Outpatient therapy with gemcitabine and docetaxel for gallbladder, biliary, and cholangio-carcinomas

1 reference

https://api.crossref.org/works/10.1007%2FS00280-010-1481-Z

21 January 2018

Recognition and management of methemoglobinemia and hemolysis in a G6PD-deficient patient on experimental anticancer drug Triapine

1 reference

https://api.crossref.org/works/10.1007%2FS00280-010-1481-Z

21 January 2018

Triapine and cytarabine is an active combination in patients with acute leukemia or myelodysplastic syndrome

1 reference

https://api.crossref.org/works/10.1007%2FS00280-010-1481-Z

21 January 2018

A phase I trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone in combination with gemcitabine for patients with advanced cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446256

31 October 2018

Time and sequence dependence of hydroxyurea in combination with gemcitabine in human KB cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446256

31 October 2018

Regulation of ribonucleotide reductase activity in mammalian cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20981545

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of ribonucleotide reductase. Comparative effects of amino- and hydroxy-substituted pyridine-2-carboxaldehyde thiosemicarbazones

1 reference

https://pubmed.ncbi.nlm.nih.gov/20981545

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and biological activity of 3- and 5-amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone

1 reference

https://pubmed.ncbi.nlm.nih.gov/20981545

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The synergistic interaction of gemcitabine and cytosine arabinoside with the ribonucleotide reductase inhibitor triapine is schedule dependent

1 reference

https://pubmed.ncbi.nlm.nih.gov/20981545

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase II study of Triapine in patients with metastatic renal cell carcinoma: a trial of the National Cancer Institute of Canada Clinical Trials Group (NCIC IND.161)

1 reference

https://pubmed.ncbi.nlm.nih.gov/20981545

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A multicenter phase II trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, Triapine®) and gemcitabine in advanced non-small-cell lung cancer with pharmacokinetic evaluation using peripheral blood mononuclear cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20981545

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00280-010-1481-Z

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

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PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

ResearchGate publication ID

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