(Q33396293)

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Antibodies associated with heparin-induced thrombocytopenia (HIT) inhibit activated protein C generation: new insights into the prothrombotic nature of HIT.

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Europe PubMed Central

PubMed publication ID

26 July 2017

Antibodies associated with heparin-induced thrombocytopenia (HIT) inhibit activated protein C generation: new insights into the prothrombotic nature of HIT. (English)

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

thrombocytopenia

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based on heuristic

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drotrecogin alfa

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based on heuristic

inferred from title

heparin-induced thrombocytopenia

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inferred from title

1

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M Anna Kowalska

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Europe PubMed Central

PubMed publication ID

26 July 2017

Richard H Aster

9

object named as

Richard H Aster

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Europe PubMed Central

PubMed publication ID

26 July 2017

10

object named as

Douglas B Cines

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Europe PubMed Central

PubMed publication ID

26 July 2017

11

object named as

Mortimer Poncz

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

3

object named as

Lubica Rauova

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Sriram Krishnaswamy

2

object named as

Sriram Krishnaswamy

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

author name string

Li Zhai

4

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Vincent Hayes

5

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Karine Amirikian

6

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Jeffrey D Esko

7

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Europe PubMed Central

PubMed publication ID

26 July 2017

Daniel W Bougie

8

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Europe PubMed Central

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26 July 2017

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publication date

19 July 2011

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Europe PubMed Central

PubMed publication ID

26 July 2017

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Europe PubMed Central

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26 July 2017

118

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Europe PubMed Central

PubMed publication ID

26 July 2017

10

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

2882-2888

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Heparin modifies the immunogenicity of positively charged proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172804

21 June 2018

Monocyte-bound PF4 in the pathogenesis of heparin-induced thrombocytopenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172804

21 June 2018

Validation of the high-dose heparin confirmatory step for the diagnosis of heparin-induced thrombocytopenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172804

21 June 2018

Extracellular histones are major mediators of death in sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172804

21 June 2018

Immune complexes formed following the binding of anti-platelet factor 4 (CXCL4) antibodies to CXCL4 stimulate human neutrophil activation and cell adhesion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172804

21 June 2018

Determinants of PF4/heparin immunogenicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172804

21 June 2018

Endogenous platelet factor 4 stimulates activated protein C generation in vivo and improves survival after thrombin or lipopolysaccharide challenge

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172804

21 June 2018

Platelet factor 4 is a negative autocrine in vivo regulator of megakaryopoiesis: clinical and therapeutic implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172804

21 June 2018

The role of surface PF4: glycosaminoglycan complexes in the pathogenesis of heparin-induced thrombocytopenia (HIT).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172804

21 June 2018

Protective signaling by activated protein C is mechanistically linked to protein C activation on endothelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172804

21 June 2018

Role of platelet surface PF4 antigenic complexes in heparin-induced thrombocytopenia pathogenesis: diagnostic and therapeutic implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172804

21 June 2018

Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172804

21 June 2018

Pathogenesis of heparin-induced thrombocytopenia and thrombosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172804

21 June 2018

Cell surface heparan sulfate participates in CXCL1-induced signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172804

21 June 2018

Heparan sulfate and development: differential roles of the N-acetylglucosamine N-deacetylase/N-sulfotransferase isozymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172804

21 June 2018

Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172804

21 June 2018

Platelet-derived CXC chemokines: old players in new games

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172804

21 June 2018

Identification of the protein C/activated protein C binding sites on the endothelial cell protein C receptor. Implications for a novel mode of ligand recognition by a major histocompatibility complex class 1-type receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172804

21 June 2018

Affinity purification of heparin-dependent antibodies to platelet factor 4 developed in heparin-induced thrombocytopenia: biological characteristics and effects on platelet activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172804

21 June 2018

Characterization of a murine monoclonal antibody that mimics heparin-induced thrombocytopenia antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172804

21 June 2018

Defining an antigenic epitope on platelet factor 4 associated with heparin-induced thrombocytopenia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172804

21 June 2018

Antibodies from patients with heparin-induced thrombocytopenia/thrombosis recognize different epitopes on heparin: platelet factor 4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172804

21 June 2018

Thrombomodulin structure and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172804

21 June 2018

Enzymatic degradation of glycosaminoglycans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172804

21 June 2018

Alanine-scanning mutagenesis of the epidermal growth factor-like domains of human thrombomodulin identifies critical residues for its cofactor activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172804

21 June 2018

Identification of the predominant glycosaminoglycan-attachment site in soluble recombinant human thrombomodulin: potential regulation of functionality by glycosyltransferase competition for serine474

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172804

21 June 2018

Crystal structure of recombinant human platelet factor 4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172804

21 June 2018

Modulation of glycosaminoglycan addition in naturally expressed and recombinant human thrombomodulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172804

21 June 2018

A diagnostic test for heparin-induced thrombocytopenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172804

21 June 2018

Immune endothelial-cell injury in heparin-associated thrombocytopenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172804

21 June 2018

Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172804

21 June 2018

Biologic and biochemic properties of recombinant platelet factor 4 demonstrate identity with the native protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172804

21 June 2018

Stable expression of a secretable deletion mutant of recombinant human thrombomodulin in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172804

21 June 2018

Chemokines and thrombogenicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172804

31 October 2018

Endothelial heparan sulfate deficiency impairs L-selectin- and chemokine-mediated neutrophil trafficking during inflammatory responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172804

31 October 2018

Overexpressing endothelial cell protein C receptor alters the hemostatic balance and protects mice from endotoxin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172804

31 October 2018

Role of the activation peptide domain in human factor X activation by the extrinsic Xase complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/21772054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Platelet factor 4 binds to glycanated forms of thrombomodulin and to protein C. A potential mechanism for enhancing generation of activated protein C

1 reference

https://pubmed.ncbi.nlm.nih.gov/21772054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transgenic mice studies demonstrate a role for platelet factor 4 in thrombosis: dissociation between anticoagulant and antithrombotic effect of heparin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21772054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The affinity of protein C for the thrombin.thrombomodulin complex is determined in a primary way by active site-dependent interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/21772054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Platelet factor 4 enhances generation of activated protein C in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/21772054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The interaction of a Ca2+-dependent monoclonal antibody with the protein C activation peptide region. Evidence for obligatory Ca2+ binding to both antigen and antibody

1 reference

https://pubmed.ncbi.nlm.nih.gov/21772054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The chondroitin sulfate moiety of thrombomodulin binds a second molecule of thrombin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21772054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Platelet factor 4 stimulates thrombomodulin protein C-activating cofactor activity. A structure-function analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21772054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1182/BLOOD-2011-02-335208

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

ResearchGate publication ID

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