(Q33407429)

English

Simultaneous inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways augment the sensitivity to actinomycin D in Ewing sarcoma

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Simultaneous inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways augment the sensitivity to actinomycin D in Ewing sarcoma (English)

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

1 reference

based on heuristic

inferred from title

author name string

Takatoshi Yamamoto

1

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Takatoshi Ohno

2

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Kazuhiko Wakahara

3

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Akihito Nagano

4

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Gou Kawai

5

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Mitsuru Saitou

6

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Iori Takigami

7

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Aya Matsuhashi

8

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Kazunari Yamada

9

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Katsuji Shimizu

10

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

publication date

10 February 2009

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Journal of Cancer Research and Clinical Oncology

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

135

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

8

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

1125-1136

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Mitogen-activated protein kinases: specific messages from ubiquitous messengers

1 reference

https://api.crossref.org/works/10.1007%2FS00432-009-0554-Z

21 January 2018

Phosphoinositide 3-hydroxide kinase blockade enhances apoptosis in the Ewing's sarcoma family of tumors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of Ewing sarcoma family of tumors: current status and outlook for the future

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EWS/Fli-1 chimeric protein is a transcriptional activator

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inactivation of the antiapoptotic phosphatidylinositol 3-kinase-Akt pathway by the combined treatment of taxol and mitogen-activated protein kinase kinase inhibition.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Actinomycin D induces apoptosis and inhibits growth of pancreatic cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Response of non-small cell lung cancer cells to the inhibitors of phosphatidylinositol 3-kinase/Akt- and MAPK kinase 4/c-Jun NH2-terminal kinase pathways: an effective therapeutic strategy for lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biology of EWS/ETS fusions in Ewing's family tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of tumorigenicity of Ewing's sarcoma cells expressing antisense RNA to EWS-fusion transcripts

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperexpression of mitogen-activated protein kinase in human breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term follow up of high-dose chemotherapy with autologous stem cell rescue in adults with Ewing tumor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The history of Z-VAD-FMK, a tool for understanding the significance of caspase inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of dactinomycin in a pediatric patient population: a United Kingdom Children's Cancer Study Group Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interference with the constitutive activation of ERK1 and ERK2 impairs EWS/FLI-1-dependent transformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ewing's sarcoma family of tumors: current management

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The in vitro and in vivo effects of 2-(4-morpholinyl)-8-phenyl-chromone (LY294002), a specific inhibitor of phosphatidylinositol 3'-kinase, in human colon cancer cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transient poly(ADP-ribosyl)ation of nuclear proteins and role of poly(ADP-ribose) polymerase in the early stages of apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the ras-mitogen-activated protein kinase pathway and phosphorylation of ets-2 at position threonine 72 in human ovarian cancer cell lines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of phospholipase D prevents actinomycin D-induced apoptosis through potentiation of phosphoinositide 3-kinase signalling pathways in Chinese-hamster ovary cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phospholipase D and its product, phosphatidic acid, mediate agonist-dependent raf-1 translocation to the plasma membrane and the activation of the mitogen-activated protein kinase pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of platelet-derived growth factor-induced cell growth signaling by a short interfering RNA for EWS-Fli1 via down-regulation of phospholipase D2 in Ewing sarcoma cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular biology of the Ewing's sarcoma/primitive neuroectodermal tumor family

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of poly(ADP-ribose) polymerase (PARP) cleavage in apoptosis. Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EWS/ETS fusions activate telomerase in Ewing's tumors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AKT1 amplification regulates cisplatin resistance in human lung cancer cells through the mammalian target of rapamycin/p70S6K1 pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased activity of oleate-dependent type phospholipase D during actinomycin D-induced apoptosis in Jurkat T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contribution of MEK/MAPK and PI3-K signaling pathway to the malignant behavior of Ewing's sarcoma cells: therapeutic prospects

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential sensitivity of chemoresistant neuroblastoma subtypes to MAPK-targeted treatment correlates with ERK, p53 expression, and signaling response to U0126

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oncogene-targeted antisense oligonucleotides for the treatment of Ewing sarcoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The MEK/MAPK pathway is involved in the resistance of breast cancer cells to the EGFR tyrosine kinase inhibitor gefitinib

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simultaneous inhibition of the mitogen-activated protein kinase kinase and phosphatidylinositol 3'-kinase pathways enhances sensitivity to paclitaxel in ovarian carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of ligand-independent ERK1/2 activity in kidney proximal tubular cells deprived of soluble survival factors up-regulates Akt and prevents apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EWS-ETS oncoproteins: the linchpins of Ewing tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of apoptosis and proliferation in Ewing's sarcoma--opportunities for targeted therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tandem high-dose chemotherapy with autologous peripheral hematopoietic progenitor cell rescue as consolidation therapy for patients with high-risk Ewing family tumors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pediatric malignancies provide unique cancer therapy targets

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of phosphatidylinositol 3'-kinase increases efficacy of paclitaxel in in vitro and in vivo ovarian cancer models.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EWS/FLI1 regulates tumor angiogenesis in Ewing's sarcoma via suppression of thrombospondins

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small interfering RNAs expressed from a Pol III promoter suppress the EWS/Fli-1 transcript in an Ewing sarcoma cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The phosphoinositide 3-kinase/Akt pathway: a new target in human renal cell carcinoma therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ATPase inhibitors suppress actinomycin D-induced apoptosis in leukemia cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of mitogen-activated protein kinase associated with prostate cancer progression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An investigation of the MEK/ERK inhibitor U0126 in acute myeloid leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting of EWS/FLI-1 by RNA interference attenuates the tumor phenotype of Ewing's sarcoma cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of phospholipase D in sphingosine 1-phosphate-induced activation of phosphatidylinositol 3-kinase and Akt in Chinese hamster ovary cells overexpressing EDG3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In situ activation of caspases and serine proteases during apoptosis detected by affinity labeling their enzyme active centers with fluorochrome-tagged inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of Akt and ERK signalling pathways induced by etoposide confer chemoresistance in gastric cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19205734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00432-009-0554-Z

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

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