(Q36363792)

13 August 2017

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title

Regulation of apoptosis and proliferation in Ewing's sarcoma--opportunities for targeted therapy (English)

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13 August 2017

Udo Kontny

1

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13 August 2017

publication date

1 March 2006

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13 August 2017

published in

Hematological Oncology

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13 August 2017

volume

24

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13 August 2017

issue

1

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13 August 2017

page(s)

14-21

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Taking aim at Ewing's sarcoma: is KIT a target and will imatinib work?

13 August 2017

cites work

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A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells

21 January 2018

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Fas ligand is present in tumors of the Ewing's sarcoma family and is cleaved into a soluble form by a metalloproteinase

21 January 2018

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Potential use of imatinib in Ewing's Sarcoma: evidence for in vitro and in vivo activity

21 January 2018

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Ewing sarcoma family of tumors

21 January 2018

1 reference

7 January 2021

Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours

1 reference

7 January 2021

Localized Ewing tumor of bone: final results of the cooperative Ewing's Sarcoma Study CESS 86.

1 reference

7 January 2021

Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone

1 reference

7 January 2021

Busulfan, melphalan, and thiotepa with or without total marrow irradiation with hematopoietic stem cell rescue for poor-risk Ewing-Sarcoma-Family tumors

1 reference

7 January 2021

EWS-FLI1 target genes recovered from Ewing's sarcoma chromatin

1 reference

7 January 2021

PTPL1 is a direct transcriptional target of EWS-FLI1 and modulates Ewing's Sarcoma tumorigenesis

1 reference

7 January 2021

Analysis of the expression of cell cycle regulators in Ewing cell lines: EWS-FLI-1 modulates p57KIP2and c-Myc expression

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7 January 2021

Alteration of mesodermal cell differentiation by EWS/FLI-1, the oncogene implicated in Ewing's sarcoma

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7 January 2021

Repression of the gene encoding the TGF-beta type II receptor is a major target of the EWS-FLI1 oncoprotein

1 reference

7 January 2021

Downregulation and forced expression of EWS-Fli1 fusion gene results in changes in the expression of G(1)regulatory genes.

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7 January 2021

The Id2 gene is a novel target of transcriptional activation by EWS-ETS fusion proteins in Ewing family tumors.

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7 January 2021

EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3.

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7 January 2021

PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors

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7 January 2021

EWS/FLI function varies in different cellular backgrounds.

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7 January 2021

Induction of tenascin-C by tumor-specific EWS-ETS fusion genes

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7 January 2021

Targeting of EWS/FLI-1 by RNA interference attenuates the tumor phenotype of Ewing's sarcoma cells in vitro

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7 January 2021

Small interfering RNAs expressed from a Pol III promoter suppress the EWS/Fli-1 transcript in an Ewing sarcoma cell line

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7 January 2021

EWS-Fli1 antisense oligodeoxynucleotide inhibits proliferation of human Ewing's sarcoma and primitive neuroectodermal tumor cells

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7 January 2021

Inhibition of EWS-FLI-1 fusion protein with antisense oligodeoxynucleotides

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7 January 2021

EWS fli-1 antisense nanocapsules inhibits ewing sarcoma-related tumor in mice

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7 January 2021

Therapeutic potentialities of EWS-Fli-1 mRNA-targeted vectorized antisense oligonucleotides.

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7 January 2021

Recombinant EWS-FLI1 oncoprotein activates transcription

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7 January 2021

Rapamycin induces the fusion-type independent downregulation of the EWS/FLI-1 proteins and inhibits Ewing's sarcoma cell proliferation

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7 January 2021

mTOR-targeted therapy of cancer with rapamycin derivatives

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7 January 2021

P53 in cancer: a paradigm for modern management of cancer

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7 January 2021

Overexpression of p53 protein in primary Ewing's sarcoma of bone: relationship to tumour stage, response and prognosis

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7 January 2021

Prognostic impact of P53 status in Ewing sarcoma

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7 January 2021

p53 mutations in human tumors with chimericEWS/FLI/1 genes

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7 January 2021

Ewing sarcomas with p53 mutation or p16/p14ARF homozygous deletion: a highly lethal subset associated with poor chemoresponse

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7 January 2021

Adenovirus-mediated p53 gene therapy in pediatric soft-tissue sarcoma cell lines: sensitization to cisplatin and doxorubicin.

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7 January 2021

The INK4a/ARF network in tumour suppression

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7 January 2021

Among genes involved in the RB dependent cell cycle regulatory cascade, the p16 tumor suppressor gene is frequently lost in the Ewing family of tumors.

1 reference

7 January 2021

Analysis of the p16INK4, p14ARF, p15, TP53, and MDM2 genes and their prognostic implications in osteosarcoma and Ewing sarcoma

1 reference

7 January 2021

Prognostic impact of INK4A deletion in Ewing sarcoma

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7 January 2021

Biochemical and cellular mechanisms of mammalian CDK inhibitors: a few unresolved issues

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7 January 2021

Identification of p21WAF1/CIP1 as a direct target of EWS-Fli1 oncogenic fusion protein

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7 January 2021

Histone acetylation and transcriptional regulatory mechanisms

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7 January 2021

Antitumor effects of histone deacetylase inhibitor on Ewing's family tumors

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7 January 2021

A cell cycle-regulated inhibitor of cyclin-dependent kinases

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7 January 2021

Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta.

1 reference

7 January 2021

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

1 reference

7 January 2021

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest

1 reference

7 January 2021

The cyclin-dependent kinase inhibitor p27 as a prognostic factor in advanced non-small cell lung cancer: its immunohistochemical evaluation using biopsy specimens

1 reference

7 January 2021

Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.

1 reference

7 January 2021

Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients

1 reference

7 January 2021

The prognostic and therapeutic relevance of p27kip1 in Ewing's family tumors

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7 January 2021

Apoptosis in cancer therapy: crossing the threshold

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7 January 2021

Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks

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7 January 2021

Overview of cell death signaling pathways

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7 January 2021

Death receptor signaling

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7 January 2021

Interferon gamma and tumour necrosis factor alpha induce a synergistic antiproliferative response in human Ewing's sarcoma cells in vitro

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7 January 2021

Inhibition of constitutive NF-kappa B activity suppresses tumorigenicity of Ewing sarcoma EW7 cells.

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7 January 2021

Sensitivity of Ewing's sarcoma to TRAIL-induced apoptosis

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7 January 2021

Cytotoxicity of Tumor necrosis factor related apoptosis-inducing ligand towards Ewing's sarcoma cell lines

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7 January 2021

Apoptotic responsiveness of the Ewing's sarcoma family of tumours to tumour necrosis factor-related apoptosis-inducing ligand (TRAIL).

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7 January 2021

Interferon gamma enhances the effectiveness of tumor necrosis factor-related apoptosis-inducing ligand receptor agonists in a xenograft model of Ewing's sarcoma

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7 January 2021

Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer

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7 January 2021

IFNgamma sensitizes for apoptosis by upregulating caspase-8 expression through the Stat1 pathway.

1 reference

7 January 2021

MIC2 is a specific marker for ewing's sarcoma and peripheral primitive neuroectodermal tumors. Evidence for a common histogenesis of ewing's sarcoma and peripheral primitive neuroectodermal tumors from MIC2 expression and specific chromosome aberrati

1 reference

7 January 2021

CD99 (MIC2) expression in paediatric B-lineage leukaemia/lymphoma reflects maturation-associated patterns of normal B-lymphopoiesis.

1 reference

7 January 2021

CD99 expression in T-lineage ALL: implications for flow cytometric detection of minimal residual disease.

1 reference

7 January 2021

Rhabdomyosarcoma of the head and neck in children

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7 January 2021

Molecular mechanisms of CD99-induced caspase-independent cell death and cell-cell adhesion in Ewing's sarcoma cells: actin and zyxin as key intracellular mediators.

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7 January 2021

How cells respond to interferons

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7 January 2021

The human type I interferon receptor. Identification of the interferon beta-specific receptor-associated phosphoprotein

1 reference

7 January 2021

IFN-beta induces serine phosphorylation of Stat-1 in Ewing's sarcoma cells and mediates apoptosis via induction of IRF-1 and activation of caspase-7

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7 January 2021

Strong inhibition of Ewing tumor xenograft growth by combination of human interferon-alpha or interferon-beta with ifosfamide

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7 January 2021

Downregulation of angiogenic factors in Ewing tumor xenografts by the combination of human interferon-alpha or interferon-beta with ifosfamide

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7 January 2021

Involvement of TNF-related apoptosis-inducing ligand (TRAIL) induction in interferon gamma-mediated apoptosis in Ewing tumor cells

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7 January 2021

Insulin-like growth factor I expression by tumors of neuroectodermal origin with the t(11;22) chromosomal translocation. A potential autocrine growth factor

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7 January 2021

Expression of an IGF-I receptor dominant negative mutant induces apoptosis, inhibits tumorigenesis and enhances chemosensitivity in Ewing's sarcoma cells.

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7 January 2021

Antitumor activity of the insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 in musculoskeletal tumors.

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7 January 2021

Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors

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7 January 2021

C-kit receptor expression in Ewing's sarcoma: lack of prognostic value but therapeutic targeting opportunities in appropriate conditions.

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7 January 2021

Imatinib inhibits proliferation of Ewing tumor cells mediated by the stem cell factor/KIT receptor pathway, and sensitizes cells to vincristine and doxorubicin-induced apoptosis.

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7 January 2021

c-KIT-expressing Ewing tumour cells are insensitive to imatinib mesylate (STI571).

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7 January 2021

Pharmacokinetics and pharmacodynamics of imatinib in a phase I trial with chronic myeloid leukemia patients

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7 January 2021

Overexpression of both p185c-erbB2 and p170mdr-1 renders breast cancer cells highly resistant to taxol

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7 January 2021

Prognostic and therapeutic relevance of HER2 expression in osteosarcoma and Ewing's sarcoma

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7 January 2021

Herceptin down-regulates HER-2/neu and vascular endothelial growth factor expression and enhances taxol-induced cytotoxicity of human Ewing's sarcoma cells in vitro and in vivo.

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7 January 2021

Effect of basic fibroblast growth factor on cultured rat neural stem cell in three-dimensional collagen gel

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7 January 2021

bFGF, neurotrophins, and the control or cortical neurogenesis.

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7 January 2021

Basic fibroblast growth factor as a growth inhibitor for cultured human tumor cells

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7 January 2021

Basic fibroblast growth factor (bFGF)-induced cell death is mediated through a caspase-dependent and p53-independent cell death receptor pathway

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7 January 2021

Basic fibroblast growth factor-induced cell death is effected through sustained activation of p38MAPK and up-regulation of the death receptor p75NTR.

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7 January 2021

Identifiers

DOI

10.1002/HON.766

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13 August 2017

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