(Q35743146)

10 August 2017

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title

Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks (English)

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10 August 2017

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molecular interaction

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1

Yves Pommier

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10 August 2017

Olivier Sordet

2

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10 August 2017

Smitha Antony

series ordinal

3

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10 August 2017

Richard L Hayward

series ordinal

4

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10 August 2017

Kurt W Kohn

series ordinal

5

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10 August 2017

language of work or name

English

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publication date

1 April 2004

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10 August 2017

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10 August 2017

23

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10 August 2017

16

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10 August 2017

2934-2949

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1207515

10 August 2017

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cites work

Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

Translocation of TRAF proteins regulates apoptotic threshold of cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

Bcl-2 proteins: targets and tools for chemosensitisation of tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

Biochemical pathways of caspase activation during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

Disruption of p53 in human cancer cells alters the responses to therapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

IRS pleckstrin homology domains bind to acidic motifs in proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

NF-kappaB activation plays an antiapoptotic role in human leukemic K562 cells exposed to ionizing radiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

Bcl-xL blocks transforming growth factor-beta 1-induced apoptosis by inhibiting cytochrome c release and not by directly antagonizing Apaf-1-dependent caspase activation in prostate epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

Endogenous inhibitors of caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

The epidermal growth factor receptor engages receptor interacting protein and nuclear factor-kappa B (NF-kappa B)-inducing kinase to activate NF-kappa B. Identification of a novel receptor-tyrosine kinase signalosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

Role of p21 in apoptosis and senescence of human colon cancer cells treated with camptothecin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

Involvement of two NF-kappa B binding elements in tumor necrosis factor alpha -, CD40-, and epstein-barr virus latent membrane protein 1-mediated induction of the cellular inhibitor of apoptosis protein 2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

PTEN induces chemosensitivity in PTEN-mutated prostate cancer cells by suppression of Bcl-2 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

Down-regulation of Bcl-2 and Bcl-xL expression with bispecific antisense treatment in glioblastoma cell lines induce cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

NF-kappaB in cancer: from innocent bystander to major culprit

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

The IKK NF-kappa B system: a treasure trove for drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

Regulation of fas-ligand expression during activation-induced cell death in T lymphocytes via nuclear factor kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

NO inhibits cytokine-induced iNOS expression and NF-kappaB activation by interfering with phosphorylation and degradation of IkappaB-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

NF-kappaB activation by triphenyltin triggers apoptosis in HL-60 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

Fas ligand-independent, FADD-mediated activation of the Fas death pathway by anticancer drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

Sensitization of cancer cells treated with cytotoxic drugs to fas-mediated cytotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

14-3-3 Interacts directly with and negatively regulates pro-apoptotic Bax

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

Heat shock proteins, cellular chaperones that modulate mitochondrial cell death pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

Mitochondria, the killer organelles and their weapons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

Inhibition of tumor necrosis factor (TNF-alpha)-mediated apoptosis by hepatitis C virus core protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

Apoptosis promotes a caspase-induced amino-terminal truncation of IkappaBalpha that functions as a stable inhibitor of NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

Regulation and function of the p53 tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

Caspase activation: the induced-proximity model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

Modulation of Akt kinase activity by binding to Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

Apoptosis and chemoresistance in transgenic cancer models

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

Apoptosis induced by topoisomerase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

Antioxidants inhibit stimulation of HIV transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

Mammalian mitochondrial IAP binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

BH3 domain of BAD is required for heterodimerization with BCL-XL and pro-apoptotic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

NF-κB-mediated Induction ofmdr1bExpression by Insulin in Rat Hepatoma Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

Role of NF-kappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

p53 upregulates cFLIP, inhibits transcription of NF-kappaB-regulated genes and induces caspase-8-independent cell death in DLD-1 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Regulation of cell death protease caspase-9 by phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Glutathione downregulates the phosphorylation of I kappa B: autoloop regulation of the NF-kappa B-mediated expression of NF-kappa B subunits by TNF-alpha in mouse vascular endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Local administration of transcription factor decoy oligonucleotides to nuclear factor-kappaB prevents carrageenin-induced inflammation in rat hind paw.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Chemotherapy: targeting the mitochondrial cell death pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-x(L) is an essential survival protein of human myeloma cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Pharmacogenomics: road to anticancer therapeutics nirvana?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Diverse agents act at multiple levels to inhibit the Rel/NF-kappaB signal transduction pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

The effect of sodium salicylate and aspirin on NF-kappa B

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Role of DNA methylation in the suppression of Apaf-1 protein in human leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Nuclear transcription factor-kappaB as a target for cancer drug development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Constitutive activation of NF-kappaB causes resistance to apoptosis in human cutaneous T cell lymphoma HuT-78 cells. Autocrine role of tumor necrosis factor and reactive oxygen intermediates

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Is NF-kappaB2/p100 a direct activator of programmed cell death?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

BH3-Only proteins-essential initiators of apoptotic cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Synergistic antileukemic interactions between 17-AAG and UCN-01 involve interruption of RAF/MEK- and AKT-related pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Mediation by NF-kappa B of cytokine induced expression of intercellular adhesion molecule 1 (ICAM-1) in an intestinal epithelial cell line, a process blocked by proteasome inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Tumor necrosis factor-alpha induces the expression of DR6, a member of the TNF receptor family, through activation of NF-kappaB

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Molecular interaction maps as information organizers and simulation guides.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Arsenite induces apoptosis via a direct effect on the mitochondrial permeability transition pore

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Id-1 expression promotes cell survival through activation of NF-kappaB signalling pathway in prostate cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappaB and activated protein-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

RelA, p50 and inhibitor of kappa B alpha are elevated in human metastatic melanoma cells and respond aberrantly to ultraviolet light B.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Activators and target genes of Rel/NF-kappaB transcription factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Activation of nuclear factor-kappaB in cultured endothelial cells by increased glucose concentration: prevention by calphostin C

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Heat shock proteins in human cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Dissecting p53 tumor suppressor functions in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Activation of the Fas pathway independently of Fas ligand during apoptosis induced by camptothecin in p53 mutant human colon carcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected]

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Apoptosis and melanoma chemoresistance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Mitochondria as a target for inducing death of malignant hematopoietic cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Mitochondria-targeting drugs arsenic trioxide and lonidamine bypass the resistance of TPA-differentiated leukemic cells to apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Specific inhibition of transcription factor NF-kappaB through intracellular protein delivery of I kappaBalpha by the Herpes virus protein VP22.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Akt is activated in response to an apoptotic signal.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Blocking caspase-3-mediated proteolysis of IKKbeta suppresses TNF-alpha-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Cell permeable BH3-peptides overcome the cytoprotective effect of Bcl-2 and Bcl-X(L).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

PTEN signaling pathways in melanoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Combination of tumor necrosis factor-alpha with sulindac augments its apoptotic potential and suppresses tumor growth of human carcinoma cells in nude mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

PTEN sensitizes prostate cancer cells to death receptor-mediated and drug-induced apoptosis through a FADD-dependent pathway.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Direct Phosphorylation of IB by IKK and IKK: Discrimination Between Free and NF-B-Bound Substrate

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Role of BAX in the apoptotic response to anticancer agents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207515

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207515

1 reference

release_mc7i52rgvffudetyw6wwuasyda

10 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/mc7i52rgvffudetyw6wwuasyda

24 November 2022

mapped directly with Wikidata item

1 reference