(Q33430191)

26 July 2017

title

Converse conformational control of smoothened activity by structurally related small molecules (English)

1 reference

26 July 2017

James K Chen

8

0 references

Zhen Yang

object named as

Zhen Yang

9

0 references

author name string

Hongbo Yang

1

1 reference

26 July 2017

Jing Xiang

2

1 reference

26 July 2017

Nengdong Wang

3

1 reference

26 July 2017

Yun Zhao

4

1 reference

26 July 2017

Joel Hyman

5

1 reference

26 July 2017

Song Li

6

1 reference

26 July 2017

Jin Jiang

7

1 reference

26 July 2017

Shuo Lin

10

1 reference

26 July 2017

language of work or name

English

0 references

publication date

14 April 2009

1 reference

Journal of Biological Chemistry

26 July 2017

published in

1 reference

26 July 2017

volume

284

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26 July 2017

issue

31

1 reference

26 July 2017

page(s)

20876-20884

1 reference

Hedgehog regulates smoothened activity by inducing a conformational switch

26 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742853

Deconstructing the hedgehog pathway in development and disease

14 July 2018

1 reference

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A small-molecule antagonist of the hedgehog signaling pathway.

14 July 2018

1 reference

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Hedgehog signaling in the murine melanoma microenvironment

14 July 2018

1 reference

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Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742853

Critical time window of hedgehog-dependent angiogenesis in murine yolk sac.

14 July 2018

1 reference

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Deregulation of the hedgehog signalling pathway: a possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma development

14 July 2018

1 reference

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Hedgehog signaling is required for adult blood stem cell formation in zebrafish embryos

14 July 2018

1 reference

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In vivo inhibition of endogenous brain tumors through systemic interference of Hedgehog signaling in mice.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742853

Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742853

Hedgehog signalling in prostate regeneration, neoplasia and metastasis

14 July 2018

1 reference

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Induction of the differentiation and apoptosis of tumor cells in vivo with efficiency and selectivity

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742853

Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.

14 July 2018

1 reference

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Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

14 July 2018

1 reference

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Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742853

Small molecule modulation of Smoothened activity

14 July 2018

1 reference

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The developmental biology of brain tumors.

14 July 2018

1 reference

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Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742853

Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742853

The patched signaling pathway in tumorigenesis and development: lessons from animal models

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742853

Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742853

Sonic hedgehog regulates branching morphogenesis in the mammalian lung

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742853

Activating Smoothened mutations in sporadic basal-cell carcinoma

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742853

A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742853

The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742853

Human homolog of patched, a candidate gene for the basal cell nevus syndrome

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742853

Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742853

Patching the gaps in Hedgehog signalling

14 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807648200

Teratogen-mediated inhibition of target tissue response to Shh signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807648200

Medulloblastoma growth inhibition by hedgehog pathway blockade

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807648200

Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807648200

A concise and diversity-oriented approach to the synthesis of SAG derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807648200

Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807648200

A molecular fingerprint for medulloblastoma.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742853

The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors

31 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19366682

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M807648200

1 reference

26 July 2017

1 reference

26 July 2017

1 reference