(Q33436238)

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Fatal Liver and Bone Marrow Toxicity by Combination Treatment of Dichloroacetate and Artesunate in a Glioblastoma Multiforme Patient: Case Report and Review of the Literature

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scholarly article

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Europe PubMed Central

PubMed publication ID

26 July 2017

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Fatal Liver and Bone Marrow Toxicity by Combination Treatment of Dichloroacetate and Artesunate in a Glioblastoma Multiforme Patient: Case Report and Review of the Literature (English)

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

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dichloroacetate

0 references

1 reference

based on heuristic

inferred from title

object named as

Thomas Efferth

3

0 references

author name string

Martin Uhl

1

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Stefan Schwab

2

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

publication date

7 October 2016

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Frontiers in Oncology

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

204

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Activity of Artemisia annua and artemisinin derivatives, in prostate carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

A Randomised, Double Blind, Placebo-Controlled Pilot Study of Oral Artesunate Therapy for Colorectal Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

Severe cholestatic hepatitis due to temozolomide: an adverse drug effect to keep in mind. Case report and review of literature.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

Glioblastoma survival: has it improved? Evidence from population-based studies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

Valproic acid and fatalities in children: a review of individual case safety reports in VigiBase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

Dihydroartemisinin suppresses glioma proliferation and invasion via inhibition of the ADAM17 pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

Dichloroacetate and cancer: new home for an orphan drug?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

Analyzing temozolomide medication errors: potentially fatal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

The effects of mixtures of dichloroacetate and trichloroacetate on induction of oxidative stress in livers of mice after subchronic exposure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

Temozolomide and radiotherapy for newly diagnosed glioblastoma multiforme: a systematic review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

Safety and efficacy field study of artesunate for dogs with non-resectable tumours

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

Dihydroartemisinin ameliorates inflammatory disease by its reciprocal effects on Th and regulatory T cell function via modulating the mammalian target of rapamycin pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

Effects of artemisinins on reticulocyte count and relationship to possible embryotoxicity in confirmed and unconfirmed malarial patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

Drug-resistant epilepsia and fulminant valproate liver toxicity. Alpers-Huttenlocher syndrome in two children confirmed post mortem by identification of p.W748S mutation in POLG gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

Mitochondrion as a novel site of dichloroacetate biotransformation by glutathione transferase zeta 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

Metabolic modulation of glioblastoma with dichloroacetate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

Dichloroacetate- and trichloroacetate-induced oxidative stress in the hepatic tissues of mice after long-term exposure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

Toxicity of the antimalarial artemisinin and its dervatives.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

Inhibitive effect of artemether on tumor growth and angiogenesis in the rat C6 orthotopic brain gliomas model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

Open-label comparative clinical study of chlorproguanil-dapsone fixed dose combination (Lapdap) alone or with three different doses of artesunate for uncomplicated Plasmodium falciparum malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

Case report of a pituitary macroadenoma treated with artemether

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

Artesunate in the treatment of metastatic uveal melanoma--first experiences

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

Treatment-related myelodysplastic syndrome after temozolomide for recurrent high-grade glioma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

Combination treatment of glioblastoma multiforme cell lines with the anti-malarial artesunate and the epidermal growth factor receptor tyrosine kinase inhibitor OSI-774.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

mRNA expression profiles for the response of human tumor cell lines to the antimalarial drugs artesunate, arteether, and artemether.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

Low-dose pharmacokinetics and oral bioavailability of dichloroacetate in naive and GST-zeta-depleted rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

Contribution of dichloroacetate and trichloroacetate to liver tumor induction in mice by trichloroethylene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

Mode of action of liver tumor induction by trichloroethylene and its metabolites, trichloroacetate and dichloroacetate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

In vivo MRI measurements of tumor growth induced by dichloroacetate: implications for mode of action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

Hematologic toxicity of sodium valproate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

Safety of artemisinin and its derivatives. A review of published and unpublished clinical trials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

Clinical pharmacology and toxicology of dichloroacetate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

Multiorgan system failure caused by valproic acid toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

The role of dichloroacetate in the hepatocarcinogenicity of trichloroethylene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

Causality assessment of adverse reactions to drugs--I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

Fatal acute pancreatitis caused by valproic acid.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

Effects of dichloroacetate in the treatment of hypoxic lactic acidosis in dogs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

Evidence of inherited urea cycle defect in a case of fatal valproate toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

Early induction of reparative hyperplasia in the liver of B6C3F1 mice treated with dichloroacetate and trichloroacetate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

21 June 2018

Molecular modes of action of artesunate in tumor cell lines.

1 reference

https://api.crossref.org/works/10.3389%2FFONC.2016.00204

21 January 2018

Inhibition of angiogenesis in vivo and growth of Kaposi's sarcoma xenograft tumors by the anti-malarial artesunate

1 reference

https://api.crossref.org/works/10.3389%2FFONC.2016.00204

21 January 2018

Dihydroartemisinin is cytotoxic to papillomavirus-expressing epithelial cells in vitro and in vivo

1 reference

https://api.crossref.org/works/10.3389%2FFONC.2016.00204

21 January 2018

Dihydroartemisinin exerts cytotoxic effects and inhibits hypoxia inducible factor-1alpha activation in C6 glioma cells.

1 reference

https://api.crossref.org/works/10.3389%2FFONC.2016.00204

21 January 2018

Artesunate induces oxidative DNA damage, sustained DNA double-strand breaks, and the ATM/ATR damage response in cancer cells

1 reference

https://api.crossref.org/works/10.3389%2FFONC.2016.00204

21 January 2018

Artesunate combined with vinorelbine plus cisplatin in treatment of advanced non-small cell lung cancer: a randomized controlled trial

1 reference

https://api.crossref.org/works/10.3389%2FFONC.2016.00204

21 January 2018

Investigation of ototoxicity of artesunate as add-on therapy in patients with metastatic or locally advanced breast cancer: new audiological results from a prospective, open, uncontrolled, monocentric phase I study

1 reference

https://api.crossref.org/works/10.3389%2FFONC.2016.00204

21 January 2018

EANO guideline for the diagnosis and treatment of anaplastic gliomas and glioblastoma.

1 reference

https://api.crossref.org/works/10.3389%2FFONC.2016.00204

21 January 2018

Traditional Chinese Medicine (TCM) and Herbal Hepatotoxicity: RUCAM and the Role of Novel Diagnostic Biomarkers Such as MicroRNAs

1 reference

https://api.crossref.org/works/10.3389%2FFONC.2016.00204

21 January 2018

A rare case of aplastic anemia caused by temozolomide

1 reference

https://api.crossref.org/works/10.3389%2FFONC.2016.00204

21 January 2018

Differential effects of dihalogenated and trihalogenated acetates in the liver of B6C3F1 mice

1 reference

https://api.crossref.org/works/10.3389%2FFONC.2016.00204

21 January 2018

Effects of dichloroacetate (DCA) on serum insulin levels and insulin-controlled signaling proteins in livers of male B6C3F1 mice

1 reference

https://api.crossref.org/works/10.3389%2FFONC.2016.00204

21 January 2018

Inhibition and recovery of rat hepatic glutathione S-transferase zeta and alteration of tyrosine metabolism following dichloroacetate exposure and withdrawal.

1 reference

https://api.crossref.org/works/10.3389%2FFONC.2016.00204

21 January 2018

Dichloroacetate- and trichloroacetate-induced phagocytic activation and production of oxidative stress in the hepatic tissues of mice after acute exposure

1 reference

https://api.crossref.org/works/10.3389%2FFONC.2016.00204

21 January 2018

Dichloroacetate treatment accelerates the development of pathology in rodent autosomal recessive polycystic kidney disease

1 reference

https://api.crossref.org/works/10.3389%2FFONC.2016.00204

21 January 2018

Artesunate combinations for treatment of malaria: meta-analysis

1 reference

https://api.crossref.org/works/10.3389%2FFONC.2016.00204

21 January 2018

First study of oral Artenimol-R in advanced cervical cancer: clinical benefit, tolerability and tumor markers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

31 October 2018

The anti-malarial artesunate is also active against cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

31 October 2018

Oral administration of dihydroartemisinin and ferrous sulfate retarded implanted fibrosarcoma growth in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053977

31 October 2018

Liver tumor induction in B6C3F1 mice by dichloroacetate and trichloroacetate

1 reference

https://pubmed.ncbi.nlm.nih.gov/27774434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of apoptosis in KG-1a leukemic cells treated with investigational drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/27774434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differences in phenotype and cell replicative behavior of hepatic tumors induced by dichloroacetate (DCA) and trichloroacetate (TCA)

1 reference

https://pubmed.ncbi.nlm.nih.gov/27774434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dichloroacetate and trichloroacetate promote clonal expansion of anchorage-independent hepatocytes in vivo and in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/27774434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Artemisinin-derived sesquiterpene lactones as potential antitumour compounds: cytotoxic action against bone marrow and tumour cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/27774434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3389/FONC.2016.00204

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

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