(Q33440753)

26 July 2017

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title

Combined strategies for the discovery of ionotropic glutamate receptor antagonists (English)

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26 July 2017

1

Alba Chimirri

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Lucia Ciranna

object named as

Lucia Ciranna

5

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Rosaria Gitto

object named as

Rosaria Gitto

6

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Laura De Luca

object named as

Laura De Luca

2

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author name string

Stefania Ferro

3

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26 July 2017

Giovanbattista De Sarro

4

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26 July 2017

publication date

1 June 2009

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26 July 2017

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26 July 2017

volume

4

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26 July 2017

issue

6

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26 July 2017

page(s)

917-922

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Pharmacophore modeling as an efficient tool in the discovery of novel noncompetitive AMPA receptor antagonists

26 July 2017

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Glutamate receptor ion channels

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Structure and gating of the glutamate receptor ion channel

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NMDA receptor subunits: function and pharmacology.

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NMDA receptor antagonists: tools in neuroscience with promise for treating CNS pathologies

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The activation gate and gating mechanism of the NMDA receptor

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Competitive AMPA receptor antagonists

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AMPA receptor antagonists as potential anticonvulsant drugs

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Molecular targets versus models for new antiepileptic drug discovery

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Glutamate-based therapeutic approaches: NR2B receptor antagonists

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Ionotropic and metabotropic glutamate receptor structure and pharmacology

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New non competitive AMPA antagonists

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AMPA receptor antagonists

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7,8-Methylenedioxy-4H-2,3-benzodiazepin-4-ones as novel AMPA receptor antagonists

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3,5-Dihydro-4H-2,3-benzodiazepine-4-thiones: a new class of AMPA receptor antagonists

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Synthesis and anticonvulsant activity of new 2,3-benzodiazepines as AMPA receptor antagonists

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Synthesis and Evaluation of Pharmacological and Pharmacokinetic Properties of 11H-[1,2,4]Triazolo[4,5-c][2,3]benzodiazepin-3(2H)-ones

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7 January 2021

Synthesis and evaluation of pharmacological properties of novel annelated 2,3-benzodiazepine derivatives

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Synthesis and pharmacological properties of new 3-ethoxycarbonyl-11H-[1,2,4]triazolo[4,5-c][2,3]benzodiazepines

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Design and development of 2,3-benzodiazepine (CFM) noncompetitive AMPA receptor antagonists

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Solid-phase Friedel–Crafts acylation on polystyrene resins-synthesis of antiepiletic 1-aryl-3,5-dihydro-4 H -2,3-benzodiazepin-4-ones

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QSAR study of anticonvulsant negative allosteric modulators of the AMPA receptor

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7 January 2021

Binding modes of noncompetitive AMPA antagonists: a computational approach

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7 January 2021

Discovery of a novel and highly potent noncompetitive AMPA receptor antagonist

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7 January 2021

3D Pharmacophore Models for 1,2,3,4-Tetrahydroisoquinoline Derivatives Acting as Anticonvulsant Agents

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7 January 2021

Novel potent anticonvulsant agent containing a tetrahydroisoquinoline skeleton

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7 January 2021

Synthesis and anticonvulsant evaluation of N-substituted isoquinoline AMPA receptor antagonists

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7 January 2021

Solution-phase parallel synthesis and evaluation of anticonvulsant activity of N-substituted-3,4-dihydroisoquinoline-2(1H)-carboxamides

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SPE-HPLC determination of new tetrahydroisoquinoline derivatives in rat plasma

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7 January 2021

Closing in on the AMPA receptor: synthesis and evaluation of 2-acetyl-1-(4'-chlorophenyl)-6-methoxy-7-[11C]methoxy-1,2,3,4-tetrahydroisoquinoline as a potential PET tracer

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Synthesis, resolution, stereochemistry, and molecular modeling of (R)- and (S)-2-acetyl-1-(4′-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline AMPAR antagonists

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7 January 2021

Improvement of water solubility of non-competitive AMPA receptor antagonists by complexation with beta-cyclodextrin

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7 January 2021

Solution-phase parallel synthesis of novel 1,2,3,4-tetrahydroisoquinoline-1-ones as anticonvulsant agents

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7 January 2021

The NMDA receptor NR2B subunit: a valid therapeutic target for multiple CNS pathologies

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7 January 2021

The N-methyl-D-aspartate receptor subunit NR2B: localization, functional properties, regulation, and clinical implications.

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7 January 2021

NR2B selective NMDA receptor antagonists

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7 January 2021

Mapping the binding site of the neuroprotectant ifenprodil on NMDA receptors.

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7 January 2021

Structural basis of NR2B-selective antagonist recognition by N-methyl-D-aspartate receptors.

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7 January 2021

Identification of critical residues in the amino terminal domain of the human NR2B subunit involved in the RO 25-6981 binding pocket

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7 January 2021

CP-101,606, an NR2B subunit selective NMDA receptor antagonist, inhibits NMDA and injury induced c-fos expression and cortical spreading depression in rodents

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1-Benzyloxy-4,5-dihydro-1H-imidazol-2-yl-amines, a novel class of NR1/2B subtype selective NMDA receptor antagonists

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7 January 2021

Orally efficacious NR2B-selective NMDA receptor antagonists

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7 January 2021

Oxamides as novel NR2B selective NMDA receptor antagonists

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7 January 2021

NR2B-selective N-methyl-D-aspartate antagonists: synthesis and evaluation of 5-substituted benzimidazoles

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7 January 2021

In vitro characterization of novel NR2B selective NMDA receptor antagonists

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7 January 2021

Benzimidazole-2-carboxamides as novel NR2B selective NMDA receptor antagonists

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7 January 2021

Discovery of novel and orally active NR2B-selective N-methyl-D-aspartate (NMDA) antagonists, pyridinol derivatives with reduced HERG binding affinity

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https://api.crossref.org/works/10.1002%2FCMDC.200900109

7 January 2021

Computational studies to discover a new NR2B/NMDA receptor antagonist and evaluation of pharmacological profile

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900109

7 January 2021

Development of 3-substituted-1H-indole derivatives as NR2B/NMDA receptor antagonists

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7 January 2021

Identifiers

DOI

10.1002/CMDC.200900109

1 reference

26 July 2017

1 reference