(Q33468432)

English

Lapatinib, a dual EGFR and HER2 tyrosine kinase inhibitor, downregulates thymidylate synthase by inhibiting the nuclear translocation of EGFR and HER2.

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scholarly article

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Europe PubMed Central

PubMed publication ID

27 July 2017

Lapatinib, a dual EGFR and HER2 tyrosine kinase inhibitor, downregulates thymidylate synthase by inhibiting the nuclear translocation of EGFR and HER2. (English)

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

10

object named as

Yung-Jue Bang

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

9

object named as

Seock-Ah Im

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

8

object named as

Do-Youn Oh

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

4

object named as

Sae-Won Han

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

11

object named as

Tae-You Kim

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Hwang-Phill Kim

1

object named as

Hwang-Phill Kim

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Young-Kwang Yoon

2

object named as

Young-Kwang Yoon

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

5

object named as

Hyung-Seok Hur

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

author name string

Jin-Won Kim

3

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Jinah Park

6

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Europe PubMed Central

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27 July 2017

Ju-Hee Lee

7

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Europe PubMed Central

PubMed publication ID

27 July 2017

language of work or name

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publication date

16 June 2009

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Europe PubMed Central

PubMed publication ID

27 July 2017

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

e5933

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

copyright license

Creative Commons Attribution 4.0 International

16 June 2009

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

Biology of SNU cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691960

21 June 2018

The growth inhibitory effect of lapatinib, a dual inhibitor of EGFR and HER2 tyrosine kinase, in gastric cancer cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691960

21 June 2018

Combined lapatinib and cetuximab enhance cytotoxicity against gefitinib-resistant lung cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691960

21 June 2018

Synergistic antitumor effect of S-1 and the epidermal growth factor receptor inhibitor gefitinib in non-small cell lung cancer cell lines: role of gefitinib-induced down-regulation of thymidylate synthase

1 reference

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21 June 2018

Enzastaurin, a protein kinase C beta inhibitor, suppresses signaling through the ribosomal S6 kinase and bad pathways and induces apoptosis in human gastric cancer cells

1 reference

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Human breast cancer cells selected for resistance to trastuzumab in vivo overexpress epidermal growth factor receptor and ErbB ligands and remain dependent on the ErbB receptor network

1 reference

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21 June 2018

Lapatinib antitumor activity is not dependent upon phosphatase and tensin homologue deleted on chromosome 10 in ErbB2-overexpressing breast cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691960

21 June 2018

Lapatinib plus capecitabine for HER2-positive advanced breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691960

21 June 2018

EGF-ERBB signalling: towards the systems level

1 reference

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21 June 2018

Prohibitin facilitates cellular senescence by recruiting specific corepressors to inhibit E2F target genes

1 reference

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21 June 2018

Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691960

21 June 2018

Nuclear EGFR signalling network in cancers: linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691960

21 June 2018

Blockade of EGFR and ErbB2 by the novel dual EGFR and ErbB2 tyrosine kinase inhibitor GW572016 sensitizes human colon carcinoma GEO cells to apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691960

21 June 2018

Co-regulation of B-Myb expression by E2F1 and EGF receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691960

21 June 2018

Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691960

21 June 2018

ERBB receptors and cancer: the complexity of targeted inhibitors

1 reference

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21 June 2018

Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691960

21 June 2018

Potential for predicting toxicity and response of fluoropyrimidines in patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691960

21 June 2018

Truncated ErbB2 receptor (p95ErbB2) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR/ErbB2 kinase inhibitor GW572016.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691960

21 June 2018

ZD1839 (Iressa) modifies the activity of key enzymes linked to fluoropyrimidine activity: rational basis for a new combination therapy with capecitabine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691960

21 June 2018

Thymidylate synthase inhibitors as anticancer agents: from bench to bedside

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691960

21 June 2018

5-Fluorouracil: mechanisms of action and clinical strategies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691960

21 June 2018

Significance of thymidylate synthase activity in renal cell carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691960

21 June 2018

The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691960

21 June 2018

Human cytomegalovirus infection induces cellular thymidylate synthase gene expression in quiescent fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691960

21 June 2018

The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: potential therapy for cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691960

21 June 2018

Nuclear localization of EGF receptor and its potential new role as a transcription factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691960

21 June 2018

Nuclear localization of p185neu tyrosine kinase and its association with transcriptional transactivation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691960

21 June 2018

New targets for pyrimidine antimetabolites in the treatment of solid tumours. 1: Thymidylate synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691960

21 June 2018

Characterization of a novel tripartite nuclear localization sequence in the EGFR family.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691960

31 October 2018

Identification of novel nuclear localization signal within the ErbB-2 protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691960

31 October 2018

Clinical significance of thymidylate synthase expression in bladder cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691960

31 October 2018

Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19529774

12 December 2020

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Identifiers

10.1371/JOURNAL.PONE.0005933

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

2009PLoSO...4.5933K

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PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

ResearchGate publication ID

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