(Q33500614)

English

Bivalent peptidomimetic ligands of TrkC are biased agonists and selectively induce neuritogenesis or potentiate neurotrophin-3 trophic signals

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Bivalent peptidomimetic ligands of TrkC are biased agonists and selectively induce neuritogenesis or potentiate neurotrophin-3 trophic signals (English)

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

6

object named as

H Uri Saragovi

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

author name string

Dianjun Chen

1

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Fouad Brahimi

2

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Yu Angell

3

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Yu-Chin Li

4

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Jennifer Moscowicz

5

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Kevin Burgess

7

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

publication date

1 September 2009

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

ACS Chemical Biology

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

9

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

769-781

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Small molecule modulation of p75 neurotrophin receptor functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

Small molecule neurotrophin receptor ligands: novel strategies for targeting Alzheimer's disease mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

A combinatorial method for solution-phase synthesis of labeled bivalent beta-turn mimics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

Advances in small molecules promoting neurotrophic function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

Neuroprotection by small molecule activators of the nerve growth factor receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

TrkA receptor "hot spots" for binding of NT-3 as a heterologous ligand

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

Modulation of p75-dependent motor neuron death by a small non-peptidyl mimetic of the neurotrophin loop 1 domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

Small, nonpeptide p75NTR ligands induce survival signaling and inhibit proNGF-induced death.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

Heterovalent selectivity and the combinatorial advantage.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

A kinase-deficient TrkC receptor isoform activates Arf6-Rac1 signaling through the scaffold protein tamalin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

Identification and characterization of compounds that potentiate NT-3-mediated Trk receptor activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

Selective small molecule peptidomimetic ligands of TrkC and TrkA receptors afford discrete or complete neurotrophic activities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

Regionally selective and dose-dependent effects of the ampakines Org 26576 and Org 24448 on local cerebral glucose utilisation in the mouse as assessed by 14C-2-deoxyglucose autoradiography.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

Long-lasting rescue of age-associated deficits in cognition and the CNS cholinergic phenotype by a partial agonist peptidomimetic ligand of TrkA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

Selectivity in neurotrophin signaling: theme and variations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

Small molecule peptidomimetic ligands of neurotrophin receptors, identifying binding sites, activation sites and regulatory sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

New templates for syntheses of ring-fused, C(10) beta-turn peptidomimetics leading to the first reported small-molecule mimic of neurotrophin-3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

Solid-phase syntheses of beta-turn analogues to mimic or disrupt protein-protein interactions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

Neurotrophin small-molecule mimetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

Design and solution structure of functional peptide mimetics of nerve growth factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

TrkA immunoglobulin-like ligand binding domains inhibit spontaneous activation of the receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

Cell surface Trk receptors mediate NGF-induced survival while internalized receptors regulate NGF-induced differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

Nerve growth factor (NGF) loop 4 dimeric mimetics activate ERK and AKT and promote NGF-like neurotrophic effects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

Neurotrophin signal transduction in the nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

Solid-phase SN2 macrocyclization reactions to form beta-turn mimics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

Development of pharmacological agents for targeting neurotrophins and their receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

A designed peptidomimetic agonistic ligand of TrkA nerve growth factor receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

Neurotrophin dependence mediated by p75NTR: contrast between rescue by BDNF and NGF.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

p75NTR: A study in contrasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

A novel juxtamembrane deletion in rat TrkA blocks differentiative but not mitogenic cell signaling in response to nerve growth factor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

Small molecule nerve growth factor analogs image receptors in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

Neurotrophins and their p75 receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

Optimal nerve growth factor trophic signals mediated by synergy of TrkA and p75 receptor-specific ligands.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

Signal transduction by the neurotrophin receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

Potent human p140-TrkA agonists derived from an anti-receptor monoclonal antibody.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

High affinity nerve growth factor binding displays a faster rate of association than p140trk binding. Implications for multi-subunit polypeptide receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

The Trk family of neurotrophin receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

21 June 2018

Differential cross-regulation of TrkA and TrkC tyrosine kinase receptors with p75.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

31 October 2018

Design of Potent Peptide Mimetics of Brain-derived Neurotrophic Factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

31 October 2018

The non-peptidyl fungal metabolite L-783,281 activates TRK neurotrophin receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

31 October 2018

p75 Co-receptors regulate ligand-dependent and ligand-independent Trk receptor activation, in part by altering Trk docking subdomains.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

31 October 2018

A novel mutation within the extracellular domain of TrkA causes constitutive receptor activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

31 October 2018

Synthetic NGF peptide derivatives prevent neuronal death via a p75 receptor-dependent mechanism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756187

31 October 2018

Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/19735123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Solution Structure and Internal Motion of a Bioactive Peptide Derived from Nerve Growth Factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19735123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective formation of homo- and heterobivalent peptidomimetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/19735123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neurotrophin receptor p75 binds neurotrophin-3 on sympathetic neurons with high affinity and specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19735123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A

1 reference

https://pubmed.ncbi.nlm.nih.gov/19735123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genuine Monovalent Ligands of TrkA Nerve Growth Factor Receptors Reveal a Novel Pharmacological Mechanism of Action

1 reference

https://pubmed.ncbi.nlm.nih.gov/19735123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small peptide mimics of nerve growth factor bind TrkA receptors and affect biological responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/19735123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A TrkA-selective, fast internalizing nerve growth factor-antibody complex induces trophic but not neuritogenic signals

1 reference

https://pubmed.ncbi.nlm.nih.gov/19735123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/CB9001415

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

ResearchGate publication ID

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