(Q33512310)

27 July 2017

title

Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries (English)

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27 July 2017

2

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27 July 2017

Darren Fayne

5

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David Lloyd

object named as

David G Lloyd

10

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Christopher P Austin

9

object named as

Christopher P Austin

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27 July 2017

11

Douglas S Auld

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27 July 2017

1

Henrike Veith

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27 July 2017

Ruili Huang

3

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27 July 2017

Tim James

4

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27 July 2017

Natalia Artemenko

6

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27 July 2017

Min Shen

7

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27 July 2017

James Inglese

8

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27 July 2017

publication date

25 October 2009

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27 July 2017

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27 July 2017

volume

27

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27 July 2017

issue

11

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27 July 2017

page(s)

1050-1055

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Identification of pregnane X receptor ligands using time-resolved fluorescence resonance energy transfer and quantitative high-throughput screening

27 July 2017

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21 June 2018

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Characterization of diversity in toxicity mechanism using in vitro cytotoxicity assays in quantitative high throughput screening

21 June 2018

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Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Summary of information on human CYP enzymes: human P450 metabolism data

21 June 2018

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Characteristics and common properties of inhibitors, inducers, and activators of CYP enzymes

21 June 2018

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Pharmacophore and three-dimensional quantitative structure activity relationship methods for modeling cytochrome p450 active sites

21 June 2018

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Drug-like properties and the causes of poor solubility and poor permeability

21 June 2018

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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

21 June 2018

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Description of a 96-well plate assay to measure cytochrome P4503A inhibition in human liver microsomes using a selective fluorescent probe

21 June 2018

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CYP3A4 drug interactions: correlation of 10 in vitro probe substrates

21 June 2018

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Pharmacogenomics: translating functional genomics into rational therapeutics

21 June 2018

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Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes

21 June 2018

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Cytochrome P450-dependent drug oxidation activities in liver microsomes of various animal species including rats, guinea pigs, dogs, monkeys, and humans

21 June 2018

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Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

21 June 2018

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21 June 2018

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21 June 2018

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https://api.crossref.org/works/10.1038%2FNBT.1581

CYP2C19 inhibition: the impact of substrate probe selection on in vitro inhibition profiles

21 January 2018

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A high-throughput screen for aggregation-based inhibition in a large compound library

31 October 2018

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31 October 2018

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31 October 2018

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31 October 2018

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Binding mode prediction of cytochrome p450 and thymidine kinase protein-ligand complexes by consideration of water and rescoring in automated docking.

31 October 2018

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The minimum significant ratio: a statistical parameter to characterize the reproducibility of potency estimates from concentration-response assays and estimation by replicate-experiment studies

31 October 2018

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12 December 2020

Structural determinants of cytochrome P450 substrate specificity, binding affinity and catalytic rate

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12 December 2020

CYP2C9 inhibition: impact of probe selection and pharmacogenetics on in vitro inhibition profiles

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12 December 2020

In vitro drug interactions of cytochrome p450: an evaluation of fluorogenic to conventional substrates

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12 December 2020

Computing with neural networks

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12 December 2020

Phenacetin O-deethylation by human liver microsomes in vitro: inhibition by chemical probes, SSRI antidepressants, nefazodone and venlafaxine

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12 December 2020

Human cytochromes P450 in the metabolism of drugs: new molecular models of enzyme-substrate interactions

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12 December 2020

Identification of promiscuous small molecule activators in high-throughput enzyme activation screens

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12 December 2020

Identifiers

DOI

10.1038/NBT.1581

1 reference

27 July 2017

1 reference

27 July 2017

1 reference