(Q33519666)

27 July 2017

Incorporation of pharmacokinetic and pharmacodynamic data into risk assessments (English)

1 reference

27 July 2017

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Lynne Haber

6

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author name string

John C Lipscomb

1

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27 July 2017

M E Bette Meek

2

1 reference

27 July 2017

Kannan Krishnan

3

1 reference

27 July 2017

Gregory L Kedderis

4

1 reference

27 July 2017

Harvey Clewell

5

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27 July 2017

1 January 2004

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Toxicology Mechanisms and Methods

27 July 2017

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27 July 2017

14

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27 July 2017

3

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27 July 2017

145-158

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Solubility properties in polymers and biological media. 2. The correlation and prediction of the solubilities of nonelectrolytes in biological tissues and fluids.

27 July 2017

1 reference

https://api.crossref.org/works/10.1080%2F15376520490429382

Hydrogen bonding. 30. Solubility of gases and vapors in biological liquids and tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376520490429382

Use of physiologically based pharmacokinetic modeling to investigate individual versus population risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376520490429382

Development of a physiologically based pharmacokinetic model of isopropanol and its metabolite acetone

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376520490429382

Review and evaluation of the potential impact of age- and gender-specific pharmacokinetic differences on tissue dosimetry

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376520490429382

Pharmacokinetics of toxic chemicals in breast milk: use of PBPK models to predict infant exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376520490429382

A quantitative property-property relationship (QPPR) approach to estimate in vitro tissue-blood partition coefficients of organic chemicals in rats and humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376520490429382

Evaluation of the potential impact of pharmacokinetic differences on tissue dosimetry in offspring during pregnancy and lactation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376520490429382

An approach for the quantitative consideration of genetic polymorphism data in chemical risk assessment: examples with warfarin and parathion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376520490429382

Physiologically based pharmacokinetic model for the inhibition of acetylcholinesterase by organophosphate esters

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376520490429382

Genetic polymorphisms in assessing interindividual variability in delivered dose

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376520490429382

Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376520490429382

Partition coefficients of some acetate esters and alcohols in water, blood, olive oil, and rat tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376520490429382

Extrapolation of in vitro enzyme induction data to humans in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376520490429382

Cytochrome P450-dependent metabolism of trichloroethylene: interindividual differences in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376520490429382

The impact of cytochrome P450 2E1-dependent metabolic variance on a risk-relevant pharmacokinetic outcome in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376520490429382

Variance of microsomal protein and cytochrome P450 2E1 and 3A forms in adult human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376520490429382

Computation of brain-blood partitioning of organic solutes via free energy calculations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376520490429382

Using structural information to create physiologically based pharmacokinetic models for all polychlorinated biphenyls

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376520490429382

An approach for incorporating tissue composition data into physiologically based pharmacokinetic models

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376520490429382

A mechanistic algorithm for predicting blood:air partition coefficients of organic chemicals with the consideration of reversible binding in hemoglobin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376520490429382

Data-derived safety factors for the evaluation of food additives and environmental contaminants

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376520490429382

Quantitative structure-pharmacokinetic relationships and drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376520490429382

Interindividual variance of cytochrome P450 forms in human hepatic microsomes: correlation of individual forms with xenobiotic metabolism and implications in risk assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376520490429382

Brain/blood distribution described by a combination of partition coefficient and molecular mass

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376520490429382

Physiologically-based pharmacokinetic modeling and bioactivation of xenobiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376520490429382

Prediction of the partition coefficient of lipophilic compounds in the air-mammal tissue system

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376520490429382

Variability of physiologically based pharmacokinetic (PBPK) model parameters and their effects on PBPK model predictions in a risk assessment for perchloroethylene (PCE)

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376520490429382

Kinetic analysis of furan biotransformation by F-344 rats in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376520490429382

Prediction of furan pharmacokinetics from hepatocyte studies: comparison of bioactivation and hepatic dosimetry in rats, mice, and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376520490429382

Incorporating human interindividual biotransformation variance in health risk assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376520490429382

Human variability and noncancer risk assessment- An analysis of the default uncertainty factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376520490429382

10.1080/15376520490429382

21 January 2018

Identifiers

DOI

1 reference

27 July 2017

1 reference