(Q33526185)

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A small molecule that inhibits the interaction of paxillin and alpha 4 integrin inhibits accumulation of mononuclear leukocytes at a site of inflammation

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Europe PubMed Central

PubMed publication ID

27 July 2017

A small molecule that inhibits the interaction of paxillin and alpha 4 integrin inhibits accumulation of mononuclear leukocytes at a site of inflammation (English)

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

author name string

Christiane Kummer

1

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Brian G Petrich

2

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

David M Rose

3

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Mark H Ginsberg

4

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

language of work or name

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publication date

22 January 2010

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

27 July 2017

285

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

13

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

9462-9469

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2843196/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Interaction of Pyk2 and PTP-PEST with leupaxin in prostate cancer cells

1 reference

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21 June 2018

Blocking the alpha 4 integrin-paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site

1 reference

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An alpha4 integrin-paxillin-Arf-GAP complex restricts Rac activation to the leading edge of migrating cells

1 reference

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21 June 2018

Paxillin: adapting to change

1 reference

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Therapeutic value of alpha-4 integrin blockade in inflammatory bowel disease:the role of natalizumab

1 reference

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Spatial restriction of alpha4 integrin phosphorylation regulates lamellipodial stability and alpha4beta1-dependent cell migration

1 reference

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Three or more routes for leukocyte migration into the central nervous system

1 reference

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Leupaxin is a critical adaptor protein in the adhesion zone of the osteoclast

1 reference

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A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and selectively inhibits alpha 4-mediated cell migration

1 reference

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The paxillin LD motifs

1 reference

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21 June 2018

Paxillin interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2843196

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Death effector domain protein PEA-15 potentiates Ras activation of extracellular signal receptor-activated kinase by an adhesion-independent mechanism

1 reference

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Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly

1 reference

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21 June 2018

Paxillin binding to a conserved sequence motif in the alpha 4 integrin cytoplasmic domain

1 reference

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Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses

1 reference

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Signaling through focal adhesion kinase

1 reference

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21 June 2018

Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2843196

21 June 2018

Paxillin LD motifs may define a new family of protein recognition domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2843196

21 June 2018

Leupaxin is a novel LIM domain protein that forms a complex with PYK2

1 reference

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21 June 2018

Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding

1 reference

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21 June 2018

Characterization of the TGF beta 1-inducible hic-5 gene that encodes a putative novel zinc finger protein and its possible involvement in cellular senescence

1 reference

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Use of peptide libraries to map the substrate specificity of a peptide-modifying enzyme: a 13 residue consensus peptide specifies biotinylation in Escherichia coli.

1 reference

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21 June 2018

Cell adhesion events mediated by alpha 4 integrins are essential in placental and cardiac development

1 reference

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21 June 2018

Primary sequence of paxillin contains putative SH2 and SH3 domain binding motifs and multiple LIM domains: identification of a vinculin and pp125Fak-binding region

1 reference

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21 June 2018

Critical role of the alpha 4 integrin/VCAM-1 pathway in cerebral leukocyte trafficking in lupus-prone MRL/fas(lpr) mice

1 reference

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21 January 2018

A controlled trial of natalizumab for relapsing multiple sclerosis

1 reference

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A randomized placebo-controlled trial of a humanized monoclonal antibody to alpha4 integrin in active Crohn's disease.

1 reference

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21 January 2018

Paxillin binding to the alpha 4 integrin subunit stimulates LFA-1 (integrin alpha L beta 2)-dependent T cell migration by augmenting the activation of focal adhesion kinase/proline-rich tyrosine kinase-2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.066993

21 January 2018

Integrin alpha 4 beta 1-dependent T cell migration requires both phosphorylation and dephosphorylation of the alpha 4 cytoplasmic domain to regulate the reversible binding of paxillin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.066993

21 January 2018

Integrin beta cytoplasmic domains differentially bind to cytoskeletal proteins.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.066993

21 January 2018

The type III connecting segment of fibronectin contains an aspartic acid residue that regulates the rate of binding to integrin alpha 4 beta 1.

1 reference

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31 October 2018

α4Integrins as Therapeutic Targets in Autoimmune Disease

1 reference

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Differential requirements for alpha4 integrins during fetal and adult hematopoiesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20097761

12 December 2020

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inferred from PubMed ID database lookup

Third Tysabri adverse case hits drug class

1 reference

https://pubmed.ncbi.nlm.nih.gov/20097761

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The affinity of integrin alpha(4)beta(1) governs lymphocyte migration

1 reference

https://pubmed.ncbi.nlm.nih.gov/20097761

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of cell migration that inhibit intracellular paxillin/alpha4 binding: a well-documented use of positional scanning libraries

1 reference

https://pubmed.ncbi.nlm.nih.gov/20097761

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M109.066993

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

ResearchGate publication ID

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