(Q33535643)

27 July 2017

title

Targeting the active site gate to yield hyperactive variants of 5-aminolevulinate synthase (English)

1 reference

27 July 2017

1 reference

Thomas Lendrihas

1

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27 July 2017

Gregory A Hunter

series ordinal

2

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27 July 2017

Gloria C Ferreira

series ordinal

3

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27 July 2017

language of work or name

English

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publication date

1 March 2010

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27 July 2017

number of pages

8

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Journal of Biological Chemistry

inferred from page(s)

published in

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27 July 2017

volume

285

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27 July 2017

issue

18

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27 July 2017

page(s)

13704-13711

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Arg-85 and Thr-430 in murine 5-aminolevulinate synthase coordinate acyl-CoA-binding and contribute to substrate specificity

27 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859533

Dissection of the stepwise mechanism to beta-lactam formation and elucidation of a rate-determining conformational change in beta-lactam synthetase

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859533

C-terminal deletions in the ALAS2 gene lead to gain of function and cause X-linked dominant protoporphyria without anemia or iron overload

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859533

Free-energy landscape of enzyme catalysis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859533

Illuminating the mechanistic roles of enzyme conformational dynamics

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859533

An NMR perspective on enzyme dynamics

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859533

Intrinsic dynamics of an enzyme underlies catalysis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859533

Crystal structure of 5-aminolevulinate synthase, the first enzyme of heme biosynthesis, and its link to XLSA in humans.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859533

Enhancement of photodynamic therapy by use of aminolevulinic acid/glycolic acid drug mixture

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859533

Aminolevulinic acid: from its unique biological function to its star role in photodynamic therapy

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859533

Pyridoxal phosphate enzymes: mechanistic, structural, and evolutionary considerations

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859533

A perspective on enzyme catalysis.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859533

Synthetic gene libraries: in search of the optimal diversity.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859533

Photodynamic therapy for cancer

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859533

The use of 5-aminolaevulinic acid as a photosensitiser in photodynamic therapy and photodiagnosis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859533

Assembly of designed oligonucleotides as an efficient method for gene recombination: a new tool in directed evolution

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859533

Synthetic shuffling expands functional protein diversity by allowing amino acids to recombine independently

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859533

Biosynthesis, biotechnological production and applications of 5-aminolevulinic acid

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859533

Mechanism of 8-amino-7-oxononanoate synthase: spectroscopic, kinetic, and crystallographic studies

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859533

A photosensitising adenovirus for photodynamic therapy

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859533

Expression of mammalian 5-aminolevulinate synthase in Escherichia coli. Overproduction, purification, and characterization

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859533

Aminolevulinate synthase: functionally important residues at a glycine loop, a putative pyridoxal phosphate cofactor-binding site

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859533

Studies on delta-aminolevulinic acid synthase of Rhodopseudomonas spheroides. Reversibility of the reaction, kinetic, spectral, and other studies related to the mechanism of action

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859533

Active site of 5-aminolevulinate synthase resides at the subunit interface. Evidence from in vivo heterodimer formation.

14 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.074237

Transient kinetic studies support refinements to the chemical and kinetic mechanisms of aminolevulinate synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.074237

Promotion of 5-aminolevulinic acid on photosynthesis of melon (Cucumis melo) seedlings under low light and chilling stress conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.074237

A heme-deficient strain of Escherichia coli has a three-base pair deletion in a “hotspot” in hemA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.074237

Analysis of numerical methods for computer simulation of kinetic processes: development of KINSIM--a flexible, portable system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.074237

Supraphysiological concentrations of 5-aminolevulinic acid dimerize in solution to produce superoxide radical anions via a protonated dihydropyrazine intermediate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.074237

The time scale of the catalytic loop motion in triosephosphate isomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.074237

A continuous spectrophotometric assay for 5-aminolevulinate synthase that utilizes substrate cycling

21 January 2018

1 reference

12 December 2020

Effectiveness of delta-aminolevulinic acid-induced protoporphyrin as a photosensitizer for photodynamic therapy in vivo

1 reference

12 December 2020

Role of arginine 439 in substrate binding of 5-aminolevulinate synthase

1 reference

12 December 2020

Pre-steady-state reaction of 5-aminolevulinate synthase. Evidence for a rate-determining product release

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M109.074237

1 reference

27 July 2017

1 reference

27 July 2017

1 reference