(Q42284101)

English

Dissection of the stepwise mechanism to beta-lactam formation and elucidation of a rate-determining conformational change in beta-lactam synthetase

scientific article published on 27 October 2008

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

19 October 2017

Dissection of the stepwise mechanism to beta-lactam formation and elucidation of a rate-determining conformational change in beta-lactam synthetase (English)

1 reference

Europe PubMed Central

PMC publication ID

19 October 2017

author name string

Mary L Raber

1

1 reference

Europe PubMed Central

PMC publication ID

19 October 2017

Michael F Freeman

2

1 reference

Europe PubMed Central

PMC publication ID

19 October 2017

Craig A Townsend

3

1 reference

Europe PubMed Central

PMC publication ID

19 October 2017

language of work or name

0 references

publication date

27 October 2008

1 reference

Europe PubMed Central

PMC publication ID

19 October 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

19 October 2017

284

1 reference

Europe PubMed Central

PMC publication ID

19 October 2017

1

1 reference

Europe PubMed Central

PMC publication ID

19 October 2017

207-217

1 reference

Europe PubMed Central

PMC publication ID

19 October 2017

Enhancement of clavulanic acid by replicative and integrative expression of ccaR and cas2 in Streptomyces clavuligerus NRRL3585.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

26 October 2017

Rate-limiting steps and role of active site Lys443 in the mechanism of carbapenam synthetase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

26 October 2017

Molecular oxygen dependent steps in fatty acid oxidation by cyclooxygenase-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

26 October 2017

Substrate product equilibrium on a reversible enzyme, triosephosphate isomerase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

26 October 2017

Effects of temperature and viscosity on R67 dihydrofolate reductase catalysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

26 October 2017

Bacterial resistance to beta-lactam antibiotics: compelling opportunism, compelling opportunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

26 October 2017

Do enzymes change the nature of transition states? Mapping the transition state for general acid-base catalysis of a serine protease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

26 October 2017

Crystal structure of carbapenam synthetase (CarA)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

26 October 2017

Industrial production of beta-lactam antibiotics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

26 October 2017

New reactions in clavulanic acid biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

26 October 2017

The catalytic cycle of beta -lactam synthetase observed by x-ray crystallographic snapshots

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

26 October 2017

Follow the protons: a low-barrier hydrogen bond unifies the mechanisms of the aspartic proteases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

26 October 2017

Kinetic mechanism of the beta-lactam synthetase of Streptomyces clavuligerus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

26 October 2017

Effects of high pressure on solvent isotope effects of yeast alcohol dehydrogenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

26 October 2017

Expansion of the clavulanic acid gene cluster: identification and in vivo functional analysis of three new genes required for biosynthesis of clavulanic acid by Streptomyces clavuligerus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

26 October 2017

Biosynthesis and molecular genetics of clavulanic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

26 October 2017

beta-Lactam synthetase: a new biosynthetic enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

26 October 2017

Solvent and viscosity effects on the rate-limiting product release step of glucoamylase during maltose hydrolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

26 October 2017

Chemistry and biosynthesis of clavulanic acid and other clavams

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

26 October 2017

Catalytic mechanism of enterococcal kanamycin kinase (APH(3')-IIIa): viscosity, thio, and solvent isotope effects support a Theorell-Chance mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

26 October 2017

How to measure and predict the molar absorption coefficient of a protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

26 October 2017

Investigation of diffusion-limited rates of chymotrypsin reactions by viscosity variation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

26 October 2017

Solvent isotope effects of enzyme systems

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

26 October 2017

A Temperature-dependent Conformational Change in d-Amino Acid Oxidase and Its Effect on Catalysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

26 October 2017

Molecular uniformity in biological catalyses. The enzymes concerned with firefly luciferin, amino acid, and fatty acid utilization are compared

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

26 October 2017

Fractional diffusion-limited component of reactions catalyzed by acetylcholinesterase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

26 October 2017

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

26 October 2017

The role of solvent viscosity in the dynamics of protein conformational changes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

26 October 2017

Viscous cosolvent effect on the ultrasonic absorption of bovine serum albumin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

26 October 2017

Viscosity-dependent structural fluctuations in enzyme catalysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

26 October 2017

Determining the Chemical Mechanisms of Enzyme-Catalyzed Reactions by Kinetic Studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

26 October 2017

Kinetic mechanism of Escherichia coli asparagine synthetase B.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

29 May 2018

Viscosity dependence of the electron transfer rate from bound cytochrome c to P840 in the photosynthetic reaction center of the green sulfur bacterium Chlorobium tepidum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

29 May 2018

Solvent isotope effects for lipoprotein lipase catalyzed hydrolysis of water-soluble p-nitrophenyl esters.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

29 May 2018

Enzyme relaxation in the reaction catalyzed by triosephosphate isomerase: detection and kinetic characterization of two unliganded forms of the enzyme.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

29 May 2018

Possible coupling of chemical to structural dynamics in subtilisin BPN' catalyzed hydrolysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

29 May 2018

Human immunodeficiency virus-1 protease. 2. Use of pH rate studies and solvent kinetic isotope effects to elucidate details of chemical mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

29 May 2018

Rational strain improvement for enhanced clavulanic acid production by genetic engineering of the glycolytic pathway in Streptomyces clavuligerus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

17 August 2018

The enzymology of clavam and carbapenem biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

17 August 2018

Implications of the effects of viscosity, macromolecular crowding, and temperature for the transient interaction between cytochrome f and plastocyanin from the cyanobacterium Phormidium laminosum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

17 August 2018

Synthesis and biological activity of AM-112 and related oxapenem analogues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

17 August 2018

Inhibition and alternate substrate studies on the mechanism of carbapenam synthetase from Erwinia carotovora

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

17 August 2018

Kinetic studies on beta-site amyloid precursor protein-cleaving enzyme (BACE). Confirmation of an iso mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

17 August 2018

Enzymatic synthesis of monocyclic beta-lactams

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

17 August 2018

The low barrier hydrogen bond in enzymatic catalysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

17 August 2018

Structural flexibility modulates the activity of human glutathione transferase P1-1. Role of helix 2 flexibility in the catalytic mechanism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

17 August 2018

Triosephosphate isomerase catalysis is diffusion controlled. Appendix: Analysis of triose phosphate equilibria in aqueous solution by 31P NMR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2610506

17 August 2018

Analysis of bacterial carbapenem antibiotic production genes reveals a novel β-lactam biosynthesis pathway.

2 references

https://api.crossref.org/works/10.1074%2FJBC.M805390200

21 January 2018

https://pubmed.ncbi.nlm.nih.gov/18955494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The use of pH studies to determine chemical mechanisms of enzyme-catalyzed reactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/18955494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Buffers of constant ionic strength for studying pH-dependent processes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18955494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and properties of gentamicin nucleotidyltransferase from Escherichia coli: Nucleotide specificity, pH optimum, and the separation of two electrophoretic variants

1 reference

https://pubmed.ncbi.nlm.nih.gov/18955494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Slow step after bond-breaking by porcine pepsin identified using solvent deuterium isotope effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/18955494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanistic studies on the aminopeptidase from Aeromonas proteolytica: a two-metal ion mechanism for peptide hydrolysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18955494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic and mechanistic studies on the hydrolysis of ubiquitin C-terminal 7-amido-4-methylcoumarin by deubiquitinating enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18955494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Energetics of substrate binding, catalysis, and product release

1 reference

https://pubmed.ncbi.nlm.nih.gov/18955494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Experimental assignment of the structure of the transition state for the association of barnase and barstar

1 reference

https://pubmed.ncbi.nlm.nih.gov/18955494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M805390200

1 reference

Europe PubMed Central

PMC publication ID

19 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 October 2017

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q42284101&oldid=1569187618"