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The INK4A/ARF locus and its two gene products
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scholarly article
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stated in
Europe PubMed Central
PubMed ID
10072356
retrieved
27 July 2017
review article
1 reference
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Europe PubMed Central
title
The INK4A/ARF locus and its two gene products
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
10072356
retrieved
27 July 2017
author
Norman Sharpless
series ordinal
1
1 reference
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Europe PubMed Central
PubMed ID
10072356
retrieved
27 July 2017
author name string
DePinho RA
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2
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Europe PubMed Central
PubMed ID
10072356
retrieved
27 July 2017
language of work or name
English
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publication date
1 February 1999
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Europe PubMed Central
PubMed ID
10072356
retrieved
27 July 2017
published in
Current Opinion in Genetics & Development
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stated in
Europe PubMed Central
PubMed ID
10072356
retrieved
27 July 2017
volume
9
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Europe PubMed Central
PubMed ID
10072356
retrieved
27 July 2017
page(s)
22-30
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stated in
Europe PubMed Central
PubMed ID
10072356
retrieved
27 July 2017
issue
1
1 reference
stated in
Europe PubMed Central
PubMed ID
10072356
retrieved
27 July 2017
cites work
Cancer cell cycles
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p53, the cellular gatekeeper for growth and division
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A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
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A cell cycle regulator potentially involved in genesis of many tumor types
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p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest
1 reference
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7 January 2021
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Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
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reference URL
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Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia-lymphoma cells
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
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Germline p16 mutations in familial melanoma
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reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
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Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus
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7 January 2021
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Increased Risk of Pancreatic Cancer in Melanoma-Prone Kindreds withp16INK4Mutations
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
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Prevalence of germ-line mutations in p16, p19ARF, and CDK4 in familial melanoma: analysis of a clinic-based population
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
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Analysis of the CDKN2A, CDKN2B and CDK4 genes in 48 Australian melanoma kindreds
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
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A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
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inferred from DOI database lookup
Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
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Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
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Inhibition of ras-induced proliferation and cellular transformation by p16INK4.
1 reference
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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
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Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition
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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
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The regulation of E2F by pRB-family proteins
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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
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Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a
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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
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reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
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Senescence of human fibroblasts induced by oncogenic Raf.
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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
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Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
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ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
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reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53
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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
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Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2
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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
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The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
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Regulation of p53 stability by Mdm2
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
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inferred from DOI database lookup
Mdm2 promotes the rapid degradation of p53
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Crossref
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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
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Tumor surveillance via the ARF-p53 pathway.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
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Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
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E1A signaling to p53 involves the p19(ARF) tumor suppressor
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
based on heuristic
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Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
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inferred from DOI database lookup
p19ARF links the tumour suppressor p53 to Ras
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
based on heuristic
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p19(Arf) induces p53-dependent apoptosis during abelson virus-mediated pre-B cell transformation
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
p14ARF links the tumour suppressors RB and p53.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
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inferred from DOI database lookup
Induction of apoptosis in fibroblasts by c-myc protein
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
p53 and E2F-1 cooperate to mediate apoptosis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Role of the INK4a locus in tumor suppression and cell mortality.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor spectrum analysis in p53-mutant mice
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations and polymorphisms in the p53, p21 and p16 genes in oral carcinomas of Indian betel quid chewers
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Among genes involved in the RB dependent cell cycle regulatory cascade, the p16 tumor suppressor gene is frequently lost in the Ewing family of tumors.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Alterations of multiple tumor suppressor genes (p53 (17p13), p16INK4 (9p21), and DBM (13q14)) in B-cell chronic lymphocytic leukemia.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Alterations of the p16 gene in head and neck cancer: frequency and association with p53, PRAD-1 and HPV
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Analysis of the p16INK4 and TP53 tumor suppressor genes in bone sarcoma pediatric patients
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Analysis of p53, p16MTS, p21WAF1 and H-ras in archived bladder tumours from workers exposed to aromatic amines
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations and altered expression of p16INK4 in human cancer.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Homozygotes for CDKN2 (p16) germline mutation in Dutch familial melanoma kindreds
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Brief report: a familial syndrome of pancreatic cancer and melanoma with a mutation in the CDKN2 tumor-suppressor gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
CDKN2A mutations in multiple primary melanomas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular genetics of familial cutaneous melanoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p16INK4A participates in a G1 arrest checkpoint in response to DNA damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A functionally inactive p53 protein in teratocarcinoma cells is activated by either DNA damage or cellular differentiation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Binding and modulation of p53 by p300/CBP coactivators
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Synergistic activation of transcription by CBP and p53
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Recruitment of p300/CBP in p53-dependent signal pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
p300/MDM2 complexes participate in MDM2-mediated p53 degradation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980004-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0959-437X(99)80004-5
1 reference
stated in
Europe PubMed Central
PubMed ID
10072356
retrieved
27 July 2017
PubMed ID
10072356
1 reference
stated in
Europe PubMed Central
PubMed ID
10072356
retrieved
27 July 2017
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