(Q33540468)

English

Hypochlorite modification of sphingomyelin generates chlorinated lipid species that induce apoptosis and proteome alterations in dopaminergic PC12 neurons in vitro.

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scholarly article

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Europe PubMed Central

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19 January 2020

Hypochlorite modification of sphingomyelin generates chlorinated lipid species that induce apoptosis and proteome alterations in dopaminergic PC12 neurons in vitro (English)

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19 January 2020

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Harald Köfeler

3

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19 January 2020

Gerald N Rechberger

4

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19 January 2020

11

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19 January 2020

Zlatko Trajanoski

12

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Zlatko Trajanoski

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19 January 2020

author name string

Christoph Nusshold

1

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19 January 2020

Manfred Kollroser

2

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19 January 2020

Helga Reicher

5

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19 January 2020

Andreas Ullen

6

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19 January 2020

Eva Bernhart

7

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19 January 2020

Sabine Waltl

8

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19 January 2020

Ingrid Kratzer

9

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19 January 2020

Albin Hermetter

10

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19 January 2020

Andelko Hrzenjak

13

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19 January 2020

Ernst Malle

14

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19 January 2020

Wolfgang Sattler

15

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19 January 2020

publication date

11 March 2010

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19 January 2020

Free Radical Biology and Medicine

1 reference

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19 January 2020

48

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19 January 2020

12

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19 January 2020

1588-1600

1 reference

Europe PubMed Central

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19 January 2020

Modification of phosphatidylserine by hypochlorous acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4061462

21 June 2018

Aberrant expression of myeloperoxidase in astrocytes promotes phospholipid oxidation and memory deficits in a mouse model of Alzheimer disease

1 reference

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21 June 2018

Mass-spectrometric characterization of phospholipids and their primary peroxidation products in rat cortical neurons during staurosporine-induced apoptosis

1 reference

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21 June 2018

A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis

1 reference

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21 June 2018

Mitochondrial fragmentation in neurodegeneration

1 reference

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21 June 2018

Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis

1 reference

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21 June 2018

Lesion genesis in a subset of patients with multiple sclerosis: a role for innate immunity?

1 reference

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21 June 2018

Activity-dependent regulation of energy metabolism by astrocytes: an update

1 reference

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21 June 2018

Chlorinated lipids and fatty acids: an emerging role in pathology.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4061462

21 June 2018

Myeloperoxidase: a target for new drug development?

1 reference

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21 June 2018

Insulin-like growth factor-1-dependent maintenance of neuronal metabolism through the phosphatidylinositol 3-kinase-Akt pathway is inhibited by C2-ceramide in CAD cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4061462

21 June 2018

The mitochondrial permeability transition in neurologic disease

1 reference

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21 June 2018

Apolipoprotein A-I coating of protamine-oligonucleotide nanoparticles increases particle uptake and transcytosis in an in vitro model of the blood-brain barrier

1 reference

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21 June 2018

Reactions of myeloperoxidase-derived oxidants with biological substrates: gaining chemical insight into human inflammatory diseases

1 reference

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21 June 2018

Fatty acid and phospholipid chlorohydrins cause cell stress and endothelial adhesion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4061462

21 June 2018

Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

1 reference

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21 June 2018

The ether lipid-deficient mouse: tracking down plasmalogen functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4061462

21 June 2018

Valproate inhibition of histone deacetylase 2 affects differentiation and decreases proliferation of endometrial stromal sarcoma cells

1 reference

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21 June 2018

Chlorinative stress: an under appreciated mediator of neurodegeneration?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4061462

21 June 2018

Oxidative stress and neurodegeneration: where are we now?

1 reference

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21 June 2018

Metabolism of 3-nitrotyrosine induces apoptotic death in dopaminergic cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4061462

21 June 2018

Modification of low-density lipoprotein by myeloperoxidase-derived oxidants and reagent hypochlorous acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4061462

21 June 2018

Hypochlorous acid-mediated mitochondrial dysfunction and apoptosis in human hepatoma HepG2 and human fetal liver cells: role of mitochondrial permeability transition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4061462

21 June 2018

Myeloperoxidase: friend and foe

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4061462

21 June 2018

A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4061462

21 June 2018

2-chlorohexadecanal derived from hypochlorite-modified high-density lipoprotein-associated plasmalogen is a natural inhibitor of endothelial nitric oxide biosynthesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4061462

21 June 2018

Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4061462

21 June 2018

Evaluation of products upon the reaction of hypohalous acid with unsaturated phosphatidylcholines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4061462

21 June 2018

Impairment of glucose metabolism in hearts from rats treated with endotoxin

1 reference

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21 June 2018

Oxidized phospholipids in minimally modified low density lipoprotein induce apoptotic signaling via activation of acid sphingomyelinase in arterial smooth muscle cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4061462

21 June 2018

Sphingosine-1-phosphate: an enigmatic signalling lipid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4061462

21 June 2018

Identification of genes involved in ceramide-dependent neuronal apoptosis using cDNA arrays

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4061462

21 June 2018

Genesis: cluster analysis of microarray data

1 reference

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21 June 2018

Reactive chlorinating species produced by myeloperoxidase target the vinyl ether bond of plasmalogens: identification of 2-chlorohexadecanal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4061462

21 June 2018

Maturation of the axonal plasma membrane requires upregulation of sphingomyelin synthesis and formation of protein-lipid complexes

1 reference

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21 June 2018

Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide.

1 reference

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21 June 2018

Molecular chlorine generated by the myeloperoxidase-hydrogen peroxide-chloride system of phagocytes converts low density lipoprotein cholesterol into a family of chlorinated sterols

1 reference

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21 June 2018

Presence of hypochlorite-modified proteins in human atherosclerotic lesions

1 reference

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21 June 2018

Chloramines and hypochlorous acid oxidize erythrocyte peroxiredoxin 2

1 reference

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31 October 2018

Elevated myeloperoxidase activity in white matter in multiple sclerosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4061462

31 October 2018

The vinyl ether linkages of plasmalogens are favored targets for myeloperoxidase-derived oxidants: a kinetic study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4061462

31 October 2018

Hypochlorous acid-derived modification of phospholipids: characterization of aminophospholipids as regulatory molecules for lipid peroxidation.

1 reference

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31 October 2018

Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in mice.

1 reference

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31 October 2018

Neutrophil-mediated accumulation of 2-ClHDA during myocardial infarction: 2-ClHDA-mediated myocardial injury

1 reference

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31 October 2018

Neuronal expression of myeloperoxidase is increased in Alzheimer's disease

1 reference

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31 October 2018

Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis.

1 reference

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31 October 2018

Focal astrocyte loss is followed by microvascular damage, with subsequent repair of the blood-brain barrier in the apparent absence of direct astrocytic contact

1 reference

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31 October 2018

Identification of alpha-chloro fatty aldehydes and unsaturated lysophosphatidylcholine molecular species in human atherosclerotic lesions

1 reference

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31 October 2018

Effects of lipoprotein lipase on uptake and transcytosis of low density lipoprotein (LDL) and LDL-associated alpha-tocopherol in a porcine in vitro blood-brain barrier model

1 reference

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31 October 2018

Effects of hypochlorous acid on unsaturated phosphatidylcholines

1 reference

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31 October 2018

Reagent or myeloperoxidase-generated hypochlorite affects discrete regions in lipid-free and lipid-associated human apolipoprotein A-I.

1 reference

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31 October 2018

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1 reference

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31 October 2018

Immunohistochemical and genetic evidence of myeloperoxidase involvement in multiple sclerosis.

1 reference

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31 October 2018

Elevated activity and microglial expression of myeloperoxidase in demyelinated cerebral cortex in multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20226853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fatty acid chlorohydrins and bromohydrins are cytotoxic to human endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20226853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholesterol chlorohydrin synthesis by the myeloperoxidase-hydrogen peroxide-chloride system: potential markers for lipoproteins oxidatively damaged by phagocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20226853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sphingomyelinase and ceramide suppress insulin-induced tyrosine phosphorylation of the insulin receptor substrate-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/20226853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.FREERADBIOMED.2010.02.037

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20226853%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20226853%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20226853%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

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