(Q33540646)

27 July 2017

title

New classes of PDE7 inhibitors identified by a fission yeast-based HTS. (English)

1 reference

27 July 2017

Charles S Hoffman

8

0 references

author name string

Manal A Alaamery

1

1 reference

27 July 2017

Arlene R Wyman

2

1 reference

27 July 2017

F Douglas Ivey

3

1 reference

27 July 2017

Christina Allain

4

1 reference

27 July 2017

Didem Demirbas

5

1 reference

27 July 2017

Lili Wang

6

1 reference

27 July 2017

Ozge Ceyhan

7

1 reference

27 July 2017

publication date

12 March 2010

1 reference

Journal of Biomolecular Screening

27 July 2017

published in

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27 July 2017

volume

15

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27 July 2017

issue

4

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27 July 2017

page(s)

359-367

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Synthesis, Structural Analysis, and Biological Evaluation of Thioxoquinazoline Derivatives as Phosphodiesterase 7 Inhibitors

27 July 2017

cites work

1 reference

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Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia

21 June 2018

1 reference

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Development of a fission yeast-based high-throughput screen to identify chemical regulators of cAMP phosphodiesterases

21 June 2018

1 reference

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Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling

21 June 2018

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Expression and activity of cGMP-dependent phosphodiesterases is up-regulated by lipopolysaccharide (LPS) in rat peritoneal macrophages

21 June 2018

1 reference

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Phosphodiesterase 7A: a new therapeutic target for alleviating chronic inflammation?

21 June 2018

1 reference

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Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use

21 June 2018

1 reference

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Cyclic nucleotide phosphodiesterases as targets for treatment of haematological malignancies

21 June 2018

1 reference

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Schizosaccharomyces pombe adenylate cyclase suppressor mutations suggest a role for cAMP phosphodiesterase regulation in feedback control of glucose/cAMP signaling

21 June 2018

1 reference

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Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7.

21 June 2018

1 reference

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Compartmentalisation of phosphodiesterases and protein kinase A: opposites attract

21 June 2018

1 reference

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Fused pyrimidine based inhibitors of phosphodiesterase 7 (PDE7): synthesis and initial structure-activity relationships.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854023

A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854023

Glucose sensing via the protein kinase A pathway in Schizosaccharomyces pombe

21 June 2018

1 reference

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Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes.

21 June 2018

1 reference

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Imperatorin inhibits HIV-1 replication through an Sp1-dependent pathway

21 June 2018

1 reference

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Suppressors of an adenylate cyclase deletion in the fission yeast Schizosaccharomyces pombe.

21 June 2018

1 reference

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Identification of purine inhibitors of phosphodiesterase 7 (PDE7).

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854023

Three-dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854023

Ubiquitous expression of phosphodiesterase 7A in human proinflammatory and immune cells.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854023

PDE7A is expressed in human B-lymphocytes and is up-regulated by elevation of intracellular cAMP.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854023

Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase Sty1/Spc1

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854023

Rolipram, a specific type IV phosphodiesterase inhibitor, is a potent inhibitor of HIV-1 replication.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854023

Glucose repression of fbp1 transcription of Schizosaccharomyces pombe is partially regulated by adenylate cyclase activation by a G protein alpha subunit encoded by gpa2 (git8).

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854023

Isolation and characterization of mutants constitutive for expression of the fbp1 gene of Schizosaccharomyces pombe

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854023

Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854023

Reduction in the intracellular cAMP level triggers initiation of sexual development in fission yeast

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854023

Differential effects on TNF alpha production by pharmacological agents with varying molecular sites of action

21 June 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20228279

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Synthesis and cellular profiling of diverse organosilicon small molecules

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20228279

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1177/1087057110362100

1 reference

27 July 2017

1 reference

27 July 2017

1 reference