(Q33541186)

27 July 2017

1 reference

title

Assessment of in silico models for fraction of unbound drug in human liver microsomes (English)

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27 July 2017

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Hua Gao

1

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27 July 2017

Stefanus J Steyn

series ordinal

2

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27 July 2017

George Chang

series ordinal

3

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27 July 2017

Jing Lin

series ordinal

4

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27 July 2017

language of work or name

English

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publication date

1 May 2010

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Expert Opinion on Drug Metabolism & Toxicology

27 July 2017

published in

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27 July 2017

volume

6

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27 July 2017

issue

5

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27 July 2017

page(s)

533-542

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Drug-like properties and the causes of poor solubility and poor permeability

27 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F17425251003671022

Computational methods for the prediction of 'drug-likeness'

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425251003671022

Prediction of 'drug-likeness'.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425251003671022

The role of absorption, distribution, metabolism, excretion and toxicity in drug discovery

21 January 2018

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Impact of Nonspecific Binding to Microsomes and Phospholipid on the Inhibition of Cytochrome P4502D6: Implications for Relating in Vitro Inhibition Data to in Vivo Drug Interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425251003671022

Microsomal protein concentration modifies the apparent inhibitory potency of CYP3A inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425251003671022

The conduct of in vitro and in vivo drug-drug interaction studies: a Pharmaceutical Research and Manufacturers of America (PhRMA) perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425251003671022

The impact of in vitro binding on in vitro-in vivo extrapolations, projections of metabolic clearance and clinical drug-drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425251003671022

Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential--toward a consensus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425251003671022

Structure-based prediction of the nonspecific binding of drugs to hepatic microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425251003671022

Evaluation of the protein binding ratio of drugs by a micro-scale ultracentrifugation method

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425251003671022

Estimation of aqueous solubility of organic compounds with QSPR approach.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425251003671022

Phenol toxicity in leukemia cells: a radical process?

21 January 2018

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QSAR analysis of skin permeability of various drugs in man as compared to in vivo and in vitro studies in rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425251003671022

Structure-activity relationships and drug disposition

21 January 2018

1 reference

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Application of quantitative structure-activity relationships for modeling drug and chemical transport across the human placenta barrier: a multivariate data analysis approach.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425251003671022

QSAR of P450 oxidation: on the value of comparing kcat and km with kcat/km

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425251003671022

QSAR analysis of membrane permeability to organic compounds

21 January 2018

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Structure-based drug metabolism predictions for drug design.

21 January 2018

1 reference

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Analysis of the Structure-Activity Relationship of the Sulfonamide Drugs Using Substituent Constants

21 January 2018

1 reference

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Comparative QSAR: Toward a Deeper Understanding of Chemicobiological Interactions

21 January 2018

1 reference

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Comparative QSAR analysis of estrogen receptor ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425251003671022

Nonspecific binding of drugs to human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425251003671022

The influence of nonspecific microsomal binding on apparent intrinsic clearance, and its prediction from physicochemical properties.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425251003671022

Hepatocellular binding of drugs: correction for unbound fraction in hepatocyte incubations using microsomal binding or drug lipophilicity data

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425251003671022

Drug lipophilicity and microsomal protein concentration as determinants in the prediction of the fraction unbound in microsomal incubations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425251003671022

Towards the predictability of drug-lipid membrane interactions: the pH-dependent affinity of propanolol to phosphatidylinositol containing liposomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425251003671022

Utilization of estimated physicochemical properties as an integrated part of predicting hepatic clearance in the early drug-discovery stage: Impact of plasma and microsomal binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425251003671022

The prediction of drug metabolism, tissue distribution, and bioavailability of 50 structurally diverse compounds in rat using mechanism-based absorption, distribution, and metabolism prediction tools

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425251003671022

Prediction of human pharmacokinetics--evaluation of methods for prediction of hepatic metabolic clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425251003671022

Blood Levels of Drug at the Equilibrium State after Multiple Dosing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425251003671022

10.1517/17425251003671022

21 January 2018

Identifiers

DOI

1 reference

release_igs7o6z3fze6jphpssi6dt2mk4

27 July 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/igs7o6z3fze6jphpssi6dt2mk4

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference