(Q39805145)

14 September 2017

title

Prediction of human pharmacokinetics--evaluation of methods for prediction of hepatic metabolic clearance (English)

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14 September 2017

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Urban Fagerholm

1

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14 September 2017

publication date

1 June 2007

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Journal of Pharmacy and Pharmacology

14 September 2017

published in

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14 September 2017

volume

59

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14 September 2017

issue

6

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14 September 2017

page(s)

803-828

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An evaluation of the in vitro metabolism data for predicting the clearance and drug-drug interaction potential of CYP2C9 substrates

14 September 2017

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Influence of albumin on the distribution and elimination kinetics of diclofenac in the isolated perfused rat liver: analysis by the impulse-response technique and the dispersion model.

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Interspecies scaling of cimetidine-theophylline pharmacokinetic interaction: interspecies scaling in pharmacokinetic interactions.

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Utility of rat liver slices to estimate hepatic clearance for application in physiologically based pharmacokinetic modeling: a study with tolbutamide, a compound with low extraction efficiency

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Hepatic structure-pharmacokinetic relationships: the hepatic disposition and metabolite kinetics of a homologous series of O-acyl derivatives of salicylic acid.

21 January 2018

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Disposition kinetics of propranolol isomers in the perfused rat liver.

21 January 2018

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21 January 2018

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In vitro and in vivo assessment of hepatic and extrahepatic metabolism of diazepam in the rat.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Extrapolation of diclofenac clearance from in vitro microsomal metabolism data: role of acyl glucuronidation and sequential oxidative metabolism of the acyl glucuronide

21 January 2018

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Interspecies pharmacokinetic scaling of metazosin, a novel alpha-adrenergic antagonist

21 January 2018

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21 January 2018

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Interspecies scaling of tolcapone, a new inhibitor of catechol-O-methyltransferase (COMT). Use of in vitro data from hepatocytes to predict metabolic clearance in animals and humans

21 January 2018

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Interspecies scaling of bosentan, a new endothelin receptor antagonist and integration of in vitro data into allometric scaling

21 January 2018

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Integration of in vitro data into allometric scaling to predict hepatic metabolic clearance in man: application to 10 extensively metabolized drugs

21 January 2018

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Prediction of hepatic metabolic clearance based on interspecies allometric scaling techniques and in vitro-in vivo correlations

21 January 2018

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Interspecies pharmacokinetic comparisons and allometric scaling of napsagatran, a low molecular weight thrombin inhibitor

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Modeling and allometric scaling of s(+)-ketoprofen pharmacokinetics and pharmacodynamics: a retrospective analysis

21 January 2018

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Use of allometry in predicting anatomical and physiological parameters of mammals

21 January 2018

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The roles of transporters and enzymes in hepatic drug processing

21 January 2018

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In Silico ADME Prediction: Data, Models, Facts and Myths

21 January 2018

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Physiologically Based Pharmacokinetic (PBPK) Modeling of Disposition of Epiroprim in Humans

21 January 2018

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In vitro human tissue models in risk assessment: report of a consensus-building workshop

21 January 2018

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Integration of in vitro data and brain weight in allometric scaling to predict clearance in humans: some suggestions

21 January 2018

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Prediction of clearance, volume of distribution and half-life by allometric scaling and by use of plasma concentrations predicted from pharmacokinetic constants: a comparative study

21 January 2018

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Interspecies scaling: predicting oral clearance in humans.

21 January 2018

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Interspecies scaling of protein drugs: prediction of clearance from animals to humans

21 January 2018

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Interspecies scaling: predicting pharmacokinetic parameters of antiepileptic drugs in humans from animals with special emphasis on clearance.

21 January 2018

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Interspecies scaling: a comparative study for the prediction of clearance and volume using two or more than two species

21 January 2018

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21 January 2018

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The pharmacokinetic principles behind scaling from preclinical results to phase I protocols

21 January 2018

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Metabolic stability for drug discovery and development: pharmacokinetic and biochemical challenges

21 January 2018

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Correlation of the intrinsic clearance of donepezil (Aricept) between in vivo and in vitro studies in rat, dog and human.

21 January 2018

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Evaluation of fresh and cryopreserved hepatocytes as in vitro drug metabolism tools for the prediction of metabolic clearance

21 January 2018

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Structural and functional polarity of canalicular and basolateral plasma membrane vesicles isolated in high yield from rat liver

21 January 2018

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Structure-hepatic disposition relationships for phenolic compounds.

21 January 2018

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Predictions of the in vivo clearance of drugs from rate of loss using human liver microsomes for phase I and phase II biotransformations.

21 January 2018

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Pharmacokinetic scale-up: accurate prediction of human pharmacokinetic profiles from animal data

21 January 2018

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Man versus beast: pharmacokinetic scaling in mammals

21 January 2018

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Interspecies scaling of clearance and volume of distribution data for five therapeutic proteins

21 January 2018

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Pharmacokinetics and interspecies scaling of recombinant human factor VIII.

21 January 2018

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Utility of Hepatocytes in Predicting Drug Metabolism: Comparison of Hepatic Intrinsic Clearance in Rats and Humans in Vivo and in Vitro

21 January 2018

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Application of a Convective-Dispersion Model to Predict In Vivo Hepatic Clearance from In Vitro Measurements Utilizing Cryopreserved Human Hepatocytes

21 January 2018

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Polar molecular surface properties predict the intestinal absorption of drugs in humans.

21 January 2018

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Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

21 January 2018

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Transport of propranolol and lidocaine through the rat blood-brain barrier. Primary role of globulin-bound drug

21 January 2018

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Strategies for using in vitro screens in drug metabolism

21 January 2018

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First-pass elimination. Basic concepts and clinical consequences

21 January 2018

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Prediction of the disposition of propafenone in humans and dogs from pharmacokinetic parameters in other animal species.

21 January 2018

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A unified model for predicting human hepatic, metabolic clearance from in vitro intrinsic clearance data in hepatocytes and microsomes

21 January 2018

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Allometric analysis of doxycycline pharmacokinetic parameters

21 January 2018

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The allometric approach for interspecies scaling of pharmacokinetic parameters

21 January 2018

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High-throughput screening approaches for investigating drug metabolism and pharmacokinetics

21 January 2018

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A dispersion model of hepatic elimination: 1. Formulation of the model and bolus considerations.

21 January 2018

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A dispersion model of hepatic elimination: 3. Application to metabolite formation and elimination kinetics.

21 January 2018

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Residence time distributions of solutes in the perfused rat liver using a dispersion model of hepatic elimination: 1. Effect of changes in perfusate flow and albumin concentration on sucrose and taurocholate

21 January 2018

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Clearance concepts in pharmacokinetics

21 January 2018

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Prediction of the pharmacokinetic parameters of reduced-dolasetron in man using in vitro-in vivo and interspecies allometric scaling.

21 January 2018

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Models of hepatic drug elimination

21 January 2018

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Experimental studies of transient mass transfer and reaction in the liver: interpretation with a heterogeneous compartment model.

21 January 2018

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Prediction of the volumes of distribution of basic drugs in humans based on data from animals

21 January 2018

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Prediction of the disposition of nine weakly acidic and six weakly basic drugs in humans from pharmacokinetic parameters in rats

21 January 2018

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Combining in vitro and in vivo pharmacokinetic data for prediction of hepatic drug clearance in humans by artificial neural networks and multivariate statistical techniques

21 January 2018

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Prediction of hepatic clearance and availability by cryopreserved human hepatocytes: an application of serum incubation method

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Interspecies pharmacokinetic scaling of DA-8159, a new erectogenic, in mice, rats, rabbits and dogs, and prediction of human pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Ion-trapping, microsomal binding, and unbound drug distribution in the hepatic retention of basic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

In vitro analysis of human drug glucuronidation and prediction of in vivo metabolic clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Impaired glutathione-conjugating capacity by cryopreserved human and rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Prediction of aztreonam pharmacokinetics in humans based on data from animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

A novel model for prediction of human drug clearance by allometric scaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Modeling the in vitro intrinsic clearance of the slowly metabolized compound tolbutamide determined in sandwich-cultured rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential--toward a consensus

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Bosentan, a new endothelin receptor antagonist: prediction of the systemic plasma clearance in man from combined in vivo and in vitro data

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

ADMET in silico modelling: towards prediction paradise?

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Estimation of metabolic rate constants in PBPK-models from liver slice experiments: what are the experimental needs?

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Disposition of the selective alpha1A-adrenoceptor antagonist tamsulosin in humans: comparison with data from interspecies scaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Determination of in vivo absorption, metabolism, and transport of drugs by the human intestinal wall and liver with a novel perfusion technique.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Prediction of human clearance from animal data and molecular structural parameters using multivariate regression analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Prediction of Human Pharmacokinetics from Animal Data and Molecular Structural Parameters using Multivariate Regression Analysis: Oral Clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Prediction of human pharmacokinetic profile in animal scale up based on normalizing time course profiles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Species Differences in Microsomal Monooxygenase Activity and Their Relationship to Biological Half-Lives

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

A comprehensive quantitative and qualitative evaluation of extrapolation of intravenous pharmacokinetic parameters from rat, dog, and monkey to humans. I. Clearance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Dissociation from albumin: a potentially rate-limiting step in the clearance of substances by the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Collagen sandwich culture affects intracellular polyamine levels of human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

A general model for the origin of allometric scaling laws in biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Comparison of prediction methods for in vivo clearance of (S,S)-3-[3-(methylsulfonyl)phenyl]-1-propylpiperidine hydrochloride, a dopamine D2 receptor antagonist, in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Kinetics of diazepam metabolism in rat hepatic microsomes and hepatocytes and their use in predicting in vivo hepatic clearance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Prediction of hepatic metabolic clearance: comparison and assessment of prediction models

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

A Microassay for Measuring Cytochrome P450IA1 and Cytochrome P450IIB1 Activities in Intact Human and Rat Hepatocytes Cultured on 96-Well Plates

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

21 January 2018

Identifiers

DOI

10.1211/JPP.59.6.0007

1 reference

14 September 2017

1 reference