(Q35724185)

9 August 2017

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title

Strategies for using in vitro screens in drug metabolism (English)

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9 August 2017

Nick Plant

1

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publication date

1 April 2004

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9 August 2017

number of pages

9

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inferred from page(s)

published in

Drug Discovery Today

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9 August 2017

volume

9

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9 August 2017

issue

7

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9 August 2017

page(s)

328-336

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Combinatorial compound libraries for drug discovery: an ongoing challenge

9 August 2017

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7 January 2021

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7 January 2021

Is survival possible without arachidonate metabolites in the brain during systemic infection?

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7 January 2021

Transcription-independent triggering of the extrinsic pathway of apoptosis by human papillomavirus 18 E2 protein.

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7 January 2021

Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions

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7 January 2021

Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7.

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7 January 2021

How useful is the "cocktail approach" for evaluating human hepatic drug metabolizing capacity using cytochrome P450 phenotyping probes in vivo?

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7 January 2021

An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons

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7 January 2021

An Improved Bacterial Test System for the Detection and Classification of Mutagens and Carcinogens

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7 January 2021

Effects of the mycotoxin ochratoxin A in a bacterial and a mammalian in vitro mutagenicity test system

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7 January 2021

Isolation of P450 enzymes from human liver

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7 January 2021

Polymorphic hydroxylation of perhexiline in vitro

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7 January 2021

Evaluation of 3'-azido-3'-deoxythymidine, morphine, and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: specificity and influence of the UGT2B7*2 polymorphism

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7 January 2021

Identification of cytochrome p450 enzymes involved in the metabolism of 4'-methyl-alpha-pyrrolidinopropiophenone, a novel scheduled designer drug, in human liver microsomes.

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7 January 2021

Gender difference in ifosfamide metabolism by human liver microsomes

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7 January 2021

Novel exogenous heme-dependent expression of mammalian cytochrome P450 using baculovirus

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7 January 2021

CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide

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7 January 2021

Metabolism of acetylaminofluorene in primary cultures of human hepatocytes: dose-response over a four-log range

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7 January 2021

Caffeine biotransformation in human hepatocyte lines derived from normal liver tissue

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Formation of a novel quinone epoxide metabolite of troglitazone with cytotoxicity to HepG2 cells

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7 January 2021

Regulation of CYP3A4 expression in human hepatocytes by pharmaceuticals and natural products

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7 January 2021

Cryopreservation of porcine hepatocyte cultures

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7 January 2021

New hepatocyte in vitro systems for drug metabolism: metabolic capacity and recommendations for application in basic research and drug development, standard operation procedures

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7 January 2021

Prediction of in vivo hepatic clearance from in vitro data using cryopreserved human hepatocytes

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7 January 2021

Development of a novel in vitro model to predict hepatic clearance using fresh, cryopreserved, and sandwich-cultured hepatocytes

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7 January 2021

Utility of Hepatocytes in Predicting Drug Metabolism: Comparison of Hepatic Intrinsic Clearance in Rats and Humans in Vivo and in Vitro

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7 January 2021

Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor

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7 January 2021

Time-dependent transcriptional induction of CYP1A1, CYP1A2 and CYP1B1 mRNAs by H+/K+ -ATPase inhibitors and other xenobiotics

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7 January 2021

Time course of cytochromes P450 decline during rat hepatocyte isolation and culture: effect of L-NAME.

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7 January 2021

Collagen sandwich culture affects intracellular polyamine levels of human hepatocytes

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7 January 2021

Novel approach for achieving double-layered cell sheets co-culture: overlaying endothelial cell sheets onto monolayer hepatocytes utilizing temperature-responsive culture dishes

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7 January 2021

Kupffer cells promote lead nitrate-induced hepatocyte apoptosis via oxidative stress

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7 January 2021

Perifusion of co-cultured hepatocytes: optimization of studies on drug metabolism and cytotoxicity in vitro

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7 January 2021

Role of kupffer cells in peroxisome proliferator-induced hepatocyte proliferation

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7 January 2021

Differentiated properties of hepatocytes induced from pancreatic cells

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7 January 2021

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7 January 2021

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7 January 2021

Differential regulation of alternate UDP-glucuronosyltransferase 1A6 gene promoters by hepatic nuclear factor-1.

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7 January 2021

Age-dependent variations of human and rat colon myofibroblasts in culture: Influence on their functional interactions with colon cancer cells

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7 January 2021

A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro

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7 January 2021

Comparison of four serum-free, cytokine-free media for analysis of endogenous erythroid colony growth in polycythemia vera and essential thrombocythemia

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7 January 2021

Transcriptional regulation of the telomerase hTERT gene as a target for cellular and viral oncogenic mechanisms

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7 January 2021

Induction of CYP3As in HepG2 cells by several drugs. Association between induction of CYP3A4 and expression of glucocorticoid receptor

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7 January 2021

Quantitative reverse transcriptase/PCR assay for the measurement of induction in cultured hepatocytes.

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7 January 2021

10.1016/S1359-6446(03)03019-8

Identifiers

DOI

1 reference

9 August 2017

1 reference