(Q33547796)

28 July 2017

1 reference

title

Anti-viral strategies of cytotoxic T lymphocytes are manifested through a variety of granule-bound pathways of apoptosis induction (English)

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28 July 2017

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Edwards KM

1

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28 July 2017

Davis JE

2

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28 July 2017

Browne KA

3

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28 July 2017

Sutton VR

4

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28 July 2017

Trapani JA

5

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28 July 2017

publication date

1 February 1999

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Immunology & Cell Biology

28 July 2017

published in

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28 July 2017

volume

77

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28 July 2017

issue

1

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28 July 2017

page(s)

76-89

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Apoptosis by death factor

28 July 2017

cites work

1 reference

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The mouse Fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster

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Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand

21 January 2018

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Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci

21 January 2018

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Structure and mechanism of interleukin-1 beta converting enzyme

21 January 2018

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Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer

21 January 2018

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The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis

21 January 2018

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Human ICE/CED-3 protease nomenclature

21 January 2018

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Molecular cloning of the interleukin-1 beta converting enzyme

21 January 2018

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A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes

21 January 2018

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Substrate and inhibitor specificity of interleukin-1 beta-converting enzyme and related caspases.

21 January 2018

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A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

21 January 2018

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DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis

21 January 2018

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Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

21 January 2018

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Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death

21 January 2018

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A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

21 January 2018

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Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis

21 January 2018

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Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis

21 January 2018

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Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32.

21 January 2018

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Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity

21 January 2018

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Cytokines and immunity to viral infections

21 January 2018

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Virus-triggered acquired immunodeficiency by cytotoxic T-cell-dependent destruction of antigen-presenting cells and lymph follicle structure

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

M-T2: a poxvirus TNF receptor homologue with dual activities.

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

A 14,500 MW protein is coded by region E3 of group C human adenoviruses

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Forced degradation of Fas inhibits apoptosis in adenovirus-infected cells

21 January 2018

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The adenovirus E3/10.4K-14.5K proteins down-modulate the apoptosis receptor Fas/Apo-1 by inducing its internalization

21 January 2018

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Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

21 January 2018

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Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis

21 January 2018

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CrmA, a poxvirus-encoded serpin, inhibits cytotoxic T-lymphocyte-mediated apoptosis

21 January 2018

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Tumor necrosis factor-induced apoptosis is mediated by a CrmA-sensitive cell death pathway

21 January 2018

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Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Differential inhibition of the Fas- and granule-mediated cytolysis pathways by the orthopoxvirus cytokine response modifier A/SPI-2 and SPI-1 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Identification and preliminary characterization of a protein motif related to the zinc finger

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Control of programmed cell death by the baculovirus genes p35 and iap.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Baculovirus inhibitors of apoptosis (IAPs) block activation of Sf-caspase-1

21 January 2018

1 reference

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Interaction of the baculovirus anti-apoptotic protein p35 with caspases. Specificity, kinetics, and characterization of the caspase/p35 complex.

21 January 2018

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Kaposi's sarcoma-associated herpesvirus encodes a functional Bcl-2 homologue

21 January 2018

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A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak

21 January 2018

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Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death

21 January 2018

1 reference

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The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins

21 January 2018

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E1B 19K inhibits Fas-mediated apoptosis through FADD-dependent sequestration of FLICE.

21 January 2018

1 reference

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E1B 19,000-molecular-weight protein interacts with and inhibits CED-4-dependent, FLICE-mediated apoptosis

21 January 2018

1 reference

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Adenovirus E1B-19K/BCL-2 interacting protein BNIP3 contains a BH3 domain and a mitochondrial targeting sequence

21 January 2018

1 reference

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Adenovirus E1B 19,000-molecular-weight protein activates c-Jun N-terminal kinase and c-Jun-mediated transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Cyclin encoded by KS herpesvirus

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Granzymes, a family of serine proteases released from granules of cytolytic T lymphocytes upon T cell receptor stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Perforin-mediated target cell lysis by cytolytic T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Induction of target cell DNA release by the cytotoxic T lymphocyte granule protease granzyme A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

A natural killer cell granule protein that induces DNA fragmentation and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Structure and function of human perforin

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

The isolation and sequence of a novel gene from a human functional T cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Specific release of proteoglycans from human natural killer cells during target lysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Molecular cloning of an inducible serine esterase gene from human cytotoxic lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Cloning of a gene that encodes a new member of the human cytotoxic cell protease family

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Characterization of a novel, human cytotoxic lymphocyte-specific serine protease cDNA clone (CSP-C)

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Structure and evolutionary origin of the human granzyme H gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

The lytic granules of natural killer cells are dual-function organelles combining secretory and pre-lysosomal compartments

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Electron microscopic study of natural killer cell-tumor cell conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Mechanism of lymphocyte-mediated cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Debate: the mechanism of lymphocyte-mediated killing. Lymphocyte-triggered internal target disintegration

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

CD8+ T cell-mediated protection against an intracellular bacterium by perforin-dependent cytotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Immune function in mice lacking the perforin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Decreased tumor surveillance in perforin-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Perforin and its role in T lymphocyte-mediated cytolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Purified perforin induces target cell lysis but not DNA fragmentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Calcium ion concentrations and DNA fragmentation in target cell destruction by murine cloned cytotoxic T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Cytolytic activity of purified cytoplasmic granules from cytotoxic rat large granular lymphocyte tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Cytolytic T cell granules. Isolation, structural, biochemical, and functional characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Lymphocyte-Mediated Cytolysis Role of Granule Mediators

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

HYPOTHESIS: CYTOTOXIC LYMPHOCYTE GRANULE SERINE PROTEASES ACTIVATE TARGET CELL ENDONUCLEASES TO TRIGGER APOPTOSIS

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

The target cell nucleus is not required for cell-mediated granzyme- or Fas-based cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

A noncytotoxic mast cell tumor line exhibits potent IgE-dependent cytotoxicity after transfection with the cytolysin/perforin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Nuclear transport of granzyme B (fragmentin-2). Dependence of perforin in vivo and cytosolic factors in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Efficient Nuclear Targeting of Granzyme B and the Nuclear Consequences of Apoptosis Induced by Granzyme B and Perforin Are Caspase-dependent, but Cell Death Is Caspase-independent

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Human perforin: rapid enrichment by immobilized metal affinity chromatography (IMAC) for whole cell cytotoxicity assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Lymphocyte granule-mediated apoptosis: matters of viral mimicry and deadly proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Cytotoxic T lymphocyte mediated cytolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Granzymes: exogenous proteinases that induce target cell apoptosis.

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Proteases and lymphocyte cytotoxic killing mechanisms

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Structural organization of the hCTLA-1 gene encoding human granzyme B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia

21 January 2018

1 reference

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Activation of pro-urokinase by the human T cell-associated serine proteinase HuTSP-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Granzyme A released upon stimulation of cytotoxic T lymphocytes activates the thrombin receptor on neuronal cells and astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

In vitro- and ex vivo-derived cytolytic leukocytes from granzyme A x B double knockout mice are defective in granule-mediated apoptosis but not lysis of target cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

An antimicrobial activity of cytolytic T cells mediated by granulysin

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Cleavage of caspase family members by granzyme B: a comparative study in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Activation of pro-caspase-7 by serine proteases includes a non-canonical specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00799.X

10.1046/J.1440-1711.1999.00799.X

21 January 2018

Identifiers

DOI

1 reference

28 July 2017

1 reference