(Q33553799)

English

Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways (English)

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

1 reference

based on heuristic

inferred from title

object named as

Jong-In Park

2

0 references

Richard F Loeser

3

object named as

Richard F Loeser

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

author name string

Weihong Yin

1

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

language of work or name

0 references

publication date

17 September 2009

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

28 July 2017

284

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

46

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

31972-31981

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

Mitochondrial dysregulation of osteoarthritic human articular chondrocytes analyzed by proteomics: a decrease in mitochondrial superoxide dismutase points to a redox imbalance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

21 June 2018

L-Sox5 and Sox6 drive expression of the aggrecan gene in cartilage by securing binding of Sox9 to a far-upstream enhancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

21 June 2018

The role of IGF-I and its binding proteins in the development of type 2 diabetes and cardiovascular disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

21 June 2018

Reference genes for normalization of gene expression studies in human osteoarthritic articular cartilage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

21 June 2018

Protein tyrosine phosphorylation and protein tyrosine nitration in redox signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

21 June 2018

Activation of interleukin-1 signaling cascades in normal and osteoarthritic articular cartilage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

21 June 2018

Aging impairs IGF-I receptor activation and induces skeletal resistance to IGF-I.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

21 June 2018

The role of the IGF system in cancer growth and metastasis: overview and recent insights

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

21 June 2018

Extracellular superoxide dismutase and oxidant damage in osteoarthritis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

21 June 2018

Bcl-2 positively regulates Sox9-dependent chondrocyte gene expression by suppressing the MEK-ERK1/2 signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

21 June 2018

Inflammation, stress, and diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

21 June 2018

IGF-I stimulation of proteoglycan synthesis by chondrocytes requires activation of the PI 3-kinase pathway but not ERK MAPK.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

21 June 2018

Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

21 June 2018

Positive and negative regulation of insulin signaling through IRS-1 phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

21 June 2018

Insulin-like growth factor-I signaling is modified during chondrocyte differentiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

21 June 2018

Serine phosphorylation proximal to its phosphotyrosine binding domain inhibits insulin receptor substrate 1 function and promotes insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

21 June 2018

Upstream and downstream of mTOR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

21 June 2018

Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

21 June 2018

Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

21 June 2018

WISP3-dependent regulation of type II collagen and aggrecan production in chondrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

21 June 2018

MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

21 June 2018

The role of reactive oxygen species in homeostasis and degradation of cartilage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

21 June 2018

Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

21 June 2018

Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

21 June 2018

Tyr(612) and Tyr(632) in human insulin receptor substrate-1 are important for full activation of insulin-stimulated phosphatidylinositol 3-kinase activity and translocation of GLUT4 in adipose cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

21 June 2018

Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

21 June 2018

Identification of novel MAP kinase pathway signaling targets by functional proteomics and mass spectrometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

21 June 2018

Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

21 June 2018

Tumor necrosis factor alpha-mediated insulin resistance, but not dedifferentiation, is abrogated by MEK1/2 inhibitors in 3T3-L1 adipocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

21 June 2018

The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

21 June 2018

Sox9 is required for cartilage formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

21 June 2018

Toward understanding SOX9 function in chondrocyte differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

21 June 2018

IGF/IGFBP axis in cartilage and bone in osteoarthritis pathogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

21 June 2018

Age-related changes in effects of insulin-like growth factor I on human osteoblast-like cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

21 June 2018

SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

21 June 2018

Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

21 June 2018

Expression of c-fos gene inhibits proteoglycan synthesis in transfected chondrocyte

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

21 June 2018

Role of insulin-like growth factors in embryonic and postnatal growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

21 June 2018

Increased oxidative stress with aging reduces chondrocyte survival: correlation with intracellular glutathione levels

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.056838

21 January 2018

The presence of molecular markers of in vivo lipid peroxidation in osteoarthritic cartilage: a pathogenic role in osteoarthritis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.056838

21 January 2018

Detection of nitrotyrosine in aging and osteoarthritic cartilage: Correlation of oxidative damage with the presence of interleukin-1beta and with chondrocyte resistance to insulin-like growth factor 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.056838

21 January 2018

Nitric oxide-mediated chondrocyte cell death requires the generation of additional reactive oxygen species

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.056838

21 January 2018

Impairment of bone healing by insulin receptor substrate-1 deficiency.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.056838

21 January 2018

Activation of stress-activated protein kinase in osteoarthritic cartilage: evidence for nitric oxide dependence

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.056838

21 January 2018

PD-0200347, an alpha2delta ligand of the voltage gated calcium channel, inhibits in vivo activation of the Erk1/2 pathway in osteoarthritic chondrocytes: a PKCalpha dependent effect

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.056838

21 January 2018

The MEK-ERK Signaling Pathway Is a Negative Regulator of Cartilage-specific Gene Expression in Embryonic Limb Mesenchyme

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.056838

21 January 2018

Shear- and compression-induced chondrocyte transcription requires MAPK activation in cartilage explants

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.056838

21 January 2018

Akt regulates skeletal development through GSK3, mTOR, and FoxOs.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.056838

21 January 2018

Prolonged treatment of human osteoarthritic chondrocytes with insulin-like growth factor-I stimulates proteoglycan synthesis but not proteoglycan matrix accumulation in alginate cultures.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797269

31 October 2018

Comparative effects of IL-1beta and hydrogen peroxide (H2O2) on catabolic and anabolic gene expression in juvenile bovine chondrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19762915

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Avocado/soybean unsaponifiables prevent the inhibitory effect of osteoarthritic subchondral osteoblasts on aggrecan and type II collagen synthesis by chondrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19762915

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19762915

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor-I (IGF-I) induces epidermal growth factor receptor transactivation and cell proliferation through reactive oxygen species

1 reference

https://pubmed.ncbi.nlm.nih.gov/19762915

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Articular chondrocytes from aging rats respond poorly to insulin-like growth factor-1: an altered signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/19762915

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction in the chondrocyte response to insulin-like growth factor 1 in aging and osteoarthritis: studies in a non-human primate model of naturally occurring disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19762915

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo selective inhibition of mitogen-activated protein kinase kinase 1/2 in rabbit experimental osteoarthritis is associated with a reduction in the development of structural changes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19762915

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevalence of degenerative morphological changes in the joints of the lower extremity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19762915

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related decline in chondrocyte response to insulin-like growth factor-I: the role of growth factor binding proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/19762915

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Manganic porphyrins possess catalase activity and protect endothelial cells against hydrogen peroxide-mediated injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/19762915

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Catalysis of the disproportionation of superoxide by metalloporphyrins. III

1 reference

https://pubmed.ncbi.nlm.nih.gov/19762915

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations in the responsiveness of senescent cells to growth factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19762915

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M109.056838

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

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