(Q33555573)

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Targeting fibroblast activation protein in tumor stroma with chimeric antigen receptor T cells can inhibit tumor growth and augment host immunity without severe toxicity

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Europe PubMed Central

PubMed publication ID

28 July 2017

Targeting fibroblast activation protein in tumor stroma with chimeric antigen receptor T cells can inhibit tumor growth and augment host immunity without severe toxicity (English)

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Europe PubMed Central

PubMed publication ID

28 July 2017

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Albert Lo

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12

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Carl H June

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Europe PubMed Central

PubMed publication ID

28 July 2017

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Liang-Chuan S Wang

1

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Europe PubMed Central

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28 July 2017

John Scholler

3

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28 July 2017

Jing Sun

4

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28 July 2017

Rajrupa S Majumdar

5

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28 July 2017

Veena Kapoor

6

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Europe PubMed Central

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28 July 2017

Michael Antzis

7

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28 July 2017

Cody E Cotner

8

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Europe PubMed Central

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28 July 2017

Laura A Johnson

9

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Europe PubMed Central

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28 July 2017

Amy C Durham

10

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Europe PubMed Central

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28 July 2017

Charalambos C Solomides

11

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Europe PubMed Central

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28 July 2017

Ellen Puré

13

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Europe PubMed Central

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28 July 2017

Steven M Albelda

14

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Europe PubMed Central

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28 July 2017

publication date

12 November 2013

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Europe PubMed Central

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28 July 2017

Cancer Immunology Research

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Europe PubMed Central

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28 July 2017

2

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Europe PubMed Central

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28 July 2017

2

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Europe PubMed Central

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28 July 2017

154-166

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Europe PubMed Central

PubMed publication ID

28 July 2017

Treatment of malignant pleural mesothelioma by fibroblast activation protein-specific re-directed T cells

1 reference

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21 June 2018

Regimen-specific effects of RNA-modified chimeric antigen receptor T cells in mice with advanced leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007316

21 June 2018

Antitumor effects of chimeric receptor engineered human T cells directed to tumor stroma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007316

21 June 2018

Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia

1 reference

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21 June 2018

Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007316

21 June 2018

Simultaneous targeting of tumor antigens and the tumor vasculature using T lymphocyte transfer synergize to induce regression of established tumors in mice.

1 reference

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21 June 2018

Enhanced effector responses in activated CD8+ T cells deficient in diacylglycerol kinases

1 reference

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21 June 2018

PD-1 blockade enhances T-cell migration to tumors by elevating IFN-γ inducible chemokines

1 reference

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21 June 2018

Recognition of glioma stem cells by genetically modified T cells targeting EGFRvIII and development of adoptive cell therapy for glioma

1 reference

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21 June 2018

Fibroblast activation protein: A potential therapeutic target in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007316

21 June 2018

T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007316

21 June 2018

Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia

1 reference

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21 June 2018

Expression of a functional CCR2 receptor enhances tumor localization and tumor eradication by retargeted human T cells expressing a mesothelin-specific chimeric antibody receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007316

21 June 2018

Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007316

21 June 2018

Multiple Injections of Electroporated Autologous T Cells Expressing a Chimeric Antigen Receptor Mediate Regression of Human Disseminated Tumor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007316

21 June 2018

Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007316

21 June 2018

Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007316

21 June 2018

Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN

1 reference

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21 June 2018

Fibroblast activation protein and chronic liver disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007316

21 June 2018

Adoptive T cell therapy for cancer in the clinic

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007316

21 June 2018

The VEGF angiogenic switch of fibroblasts is regulated by MMP-7 from cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007316

21 June 2018

Principles of adoptive T cell cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007316

21 June 2018

Increased intensity lymphodepletion and adoptive immunotherapy--how far can we go?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007316

21 June 2018

Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007316

21 June 2018

Fibroblast activation protein: a serine protease expressed at the remodeling interface in idiopathic pulmonary fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007316

21 June 2018

Tumor immunotherapy targeting fibroblast activation protein, a product expressed in tumor-associated fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007316

21 June 2018

Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007316

21 June 2018

Structural and kinetic analysis of the substrate specificity of human fibroblast activation protein alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007316

21 June 2018

Stromal fibroblasts in cancer initiation and progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007316

21 June 2018

IL-2 intratumoral immunotherapy enhances CD8+ T cells that mediate destruction of tumor cells and tumor-associated vasculature: a novel mechanism for IL-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007316

21 June 2018

A Phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007316

21 June 2018

Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

1 reference

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21 June 2018

Targeted disruption of mouse fibroblast activation protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007316

21 June 2018

Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007316

21 June 2018

Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007316

21 June 2018

Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007316

21 June 2018

The gene for fibroblast activation protein alpha (FAP), a putative cell surface-bound serine protease expressed in cancer stroma and wound healing, maps to chromosome band 2q23

1 reference

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21 June 2018

Cell-surface glycoproteins of human sarcomas: differential expression in normal and malignant tissues and cultured cells

1 reference

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21 June 2018

Cell surface glycoprotein of reactive stromal fibroblasts as a potential antibody target in human epithelial cancers

1 reference

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21 June 2018

Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo

1 reference

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31 October 2018

Fibroblast activation protein and its relationship to clinical outcome in pancreatic adenocarcinoma

1 reference

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Effective immunoconjugate therapy in cancer models targeting a serine protease of tumor fibroblasts

1 reference

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31 October 2018

FAP-alpha and uPA show different expression patterns in premalignant and malignant esophageal lesions

1 reference

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31 October 2018

Fibroblast activation protein: differential expression and serine protease activity in reactive stromal fibroblasts of melanocytic skin tumors

1 reference

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Expression of the fibroblast activation protein during mouse embryo development

1 reference

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1 reference

https://pubmed.ncbi.nlm.nih.gov/24778279

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of human lung tumor-associated fibroblasts and their ability to modulate the activation of tumor-associated T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24778279

12 December 2020

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Clinical implications of fibroblast activation protein in patients with colon cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/24778279

12 December 2020

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inferred from PubMed ID database lookup

Ovarian cancer-associated fibroblasts contribute to epithelial ovarian carcinoma metastasis by promoting angiogenesis, lymphangiogenesis and tumor cell invasion

1 reference

https://pubmed.ncbi.nlm.nih.gov/24778279

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/2326-6066.CIR-13-0027

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Europe PubMed Central

PubMed publication ID

28 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

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