(Q33556249)

English

Urokinase-type plasminogen activator receptor (uPAR) ligation induces a raft-localized integrin signaling switch that mediates the hypermotile phenotype of fibrotic fibroblasts

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scholarly article

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Europe PubMed Central

PubMed publication ID

28 July 2017

Urokinase-type plasminogen activator receptor (uPAR) ligation induces a raft-localized integrin signaling switch that mediates the hypermotile phenotype of fibrotic fibroblasts (English)

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

1 reference

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Brian D Southern

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Brian D Southern

2

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Candece L Gladson

9

object named as

Candece L Gladson

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

author name string

Lisa M Grove

1

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Europe PubMed Central

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28 July 2017

Tong H Jin

3

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28 July 2017

Kimberly E White

4

1 reference

Europe PubMed Central

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28 July 2017

Sailaja Paruchuri

5

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

Efrat Harel

6

1 reference

Europe PubMed Central

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28 July 2017

Ying Wei

7

1 reference

Europe PubMed Central

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28 July 2017

Shaik O Rahaman

8

1 reference

Europe PubMed Central

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28 July 2017

Qiang Ding

10

1 reference

Europe PubMed Central

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28 July 2017

Charles S Craik

11

1 reference

Europe PubMed Central

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28 July 2017

Harold A Chapman

12

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28 July 2017

Mitchell A Olman

13

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28 July 2017

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publication date

18 March 2014

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28 July 2017

Journal of Biological Chemistry

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28 July 2017

289

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Europe PubMed Central

PubMed publication ID

28 July 2017

18

1 reference

Europe PubMed Central

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28 July 2017

12791-12804

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4007467/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

FAK-related nonkinase is a multifunctional negative regulator of pulmonary fibrosis

1 reference

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MMP-9 and uPAR regulated glioma cell migration

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suPAR as a prognostic biomarker in sepsis

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Crosstalk between the urokinase-type plasminogen activator receptor and EGF receptor variant III supports survival and growth of glioblastoma cells

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Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis

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21 June 2018

Circulating soluble urokinase plasminogen activator receptor is stably elevated during the first week of treatment in the intensive care unit and predicts mortality in critically ill patients

1 reference

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Localization of uPAR and MMP-9 in lipid rafts is critical for migration, invasion and angiogenesis in human breast cancer cells

1 reference

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The antifibrotic effects of plasminogen activation occur via prostaglandin E2 synthesis in humans and mice

1 reference

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21 June 2018

Antagonistic anti-urokinase plasminogen activator receptor (uPAR) antibodies significantly inhibit uPAR-mediated cellular signaling and migration

1 reference

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Downregulation of FAK-related non-kinase mediates the migratory phenotype of human fibrotic lung fibroblasts

1 reference

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Lipid rafts as a membrane-organizing principle

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21 June 2018

Urokinase receptor mediates lung fibroblast attachment and migration toward provisional matrix proteins through interaction with multiple integrins

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The urokinase receptor as an entertainer of signal transduction

1 reference

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21 June 2018

Intact and cleaved uPAR forms: diagnostic and prognostic value in cancer

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The interaction between urokinase receptor and vitronectin in cell adhesion and signalling

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uPAR-induced cell adhesion and migration: vitronectin provides the key

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Accelerated variant of idiopathic pulmonary fibrosis: clinical behavior and gene expression pattern

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Plasma levels of soluble urokinase-type plasminogen activator receptor (suPAR) and early mortality risk among patients enrolling for antiretroviral treatment in South Africa

1 reference

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Urokinase receptors are required for alpha 5 beta 1 integrin-mediated signaling in tumor cells

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A region in urokinase plasminogen receptor domain III controlling a functional association with alpha5beta1 integrin and tumor growth

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The clinical course of patients with idiopathic pulmonary fibrosis

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Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding.

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Integrins regulate Rac targeting by internalization of membrane domains

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Lipid rafts: elusive or illusive?

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Dimerization controls the lipid raft partitioning of uPAR/CD87 and regulates its biological functions

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uPAR: a versatile signalling orchestrator

1 reference

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Convergence of the adhesive and fibrinolytic systems: recognition of urokinase by integrin alpha Mbeta 2 as well as by the urokinase receptor regulates cell adhesion and migration

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Urokinase receptors promote beta1 integrin function through interactions with integrin alpha3beta1.

1 reference

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Lipid rafts and signal transduction

1 reference

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Urokinase receptor and integrin partnership: coordination of signaling for cell adhesion, migration and growth.

1 reference

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21 June 2018

Role of urokinase receptor and caveolin in regulation of integrin signaling.

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A role for caveolin and the urokinase receptor in integrin-mediated adhesion and signaling

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Functions of lipid rafts in biological membranes

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1 reference

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Binding of urokinase-type plasminogen activator to its receptor in MCF-7 cells activates extracellular signal-regulated kinase 1 and 2 which is required for increased cellular motility

1 reference

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21 June 2018

Regulation of integrin function by the urokinase receptor

1 reference

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Differential expression of the urokinase receptor in fibroblasts from normal and fibrotic human lungs

1 reference

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Enhanced migration of fibroblasts derived from lungs with fibrotic lesions

1 reference

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Determinants of progression in idiopathic pulmonary fibrosis

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Induction of cell migration by pro-urokinase binding to its receptor: possible mechanism for signal transduction in human epithelial cells

1 reference

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21 June 2018

Critical role of integrin alpha 5 beta 1 in urokinase (uPA)/urokinase receptor (uPAR, CD87) signaling

1 reference

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21 January 2018

Idiopathic pulmonary fibrosis: relationship between histopathologic features and mortality

1 reference

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21 January 2018

Detergent resistance as a tool in membrane research

1 reference

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21 January 2018

Focal adhesion kinase (FAK)-related non-kinase inhibits myofibroblast differentiation through differential MAPK activation in a FAK-dependent manner

1 reference

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21 January 2018

The pattern of enhancement of Src kinase activity on platelet-derived growth factor stimulation of glioblastoma cells is affected by the integrin engaged

1 reference

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Inhibition of protein palmitoylation, raft localization, and T cell signaling by 2-bromopalmitate and polyunsaturated fatty acids.

1 reference

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21 January 2018

The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak

1 reference

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21 January 2018

Plasma concentrations of soluble urokinase-type plasminogen activator receptor are increased in patients with malaria and are associated with a poor clinical or a fatal outcome

1 reference

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21 January 2018

Urokinase-type plasminogen activator receptor regulates a novel pathway of fibronectin matrix assembly requiring Src-dependent transactivation of epidermal growth factor receptor

1 reference

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21 January 2018

Inducible lung-specific urokinase expression reduces fibrosis and mortality after lung injury in mice

1 reference

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21 January 2018

Treatment of bleomycin-induced pulmonary fibrosis by transfer of urokinase-type plasminogen activator genes

1 reference

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21 January 2018

Prevention of bleomycin-induced lung fibrosis by aerosolization of heparin or urokinase in rabbits

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21 January 2018

Significance of pulmonary arterial pressure and diffusion capacity of the lung as prognosticator in patients with idiopathic pulmonary fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24644284

12 December 2020

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inferred from PubMed ID database lookup

The impact of pulmonary arterial hypertension on idiopathic pulmonary fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24644284

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gas exchange at a given degree of volume restriction is different in sarcoidosis and idiopathic pulmonary fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24644284

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based on heuristic

inferred from PubMed ID database lookup

Mac-1 (CD11b/CD18) and the urokinase receptor (CD87) form a functional unit on monocytic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24644284

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymerization of fibrinogen in murine bleomycin-induced lung injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/24644284

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M113.498576

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

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