(Q34162183)

31 July 2017

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title

uPAR: a versatile signalling orchestrator (English)

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31 July 2017

2

Peter Carmeliet

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31 July 2017

Francesco Blasi

1

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31 July 2017

publication date

1 December 2002

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Nature Reviews Molecular Cell Biology

31 July 2017

published in

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31 July 2017

volume

3

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31 July 2017

issue

12

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31 July 2017

page(s)

932-943

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Structure-function relationships in the receptor for urokinase-type plasminogen activator. Comparison to other members of the Ly-6 family and snake venom alpha-neurotoxins

31 July 2017

cites work

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Domain interplay in the urokinase receptor. Requirement for the third domain in high affinity ligand binding and demonstration of ligand contact sites in distinct receptor domains.

31 March 2020

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Identification of specific sites involved in ligand binding by photoaffinity labeling of the receptor for the urokinase-type plasminogen activator. Residues located at equivalent positions in uPAR domains I and III participate in the assembly [...]

31 March 2020

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Regulation of cell adhesion by PAI-1.

31 March 2020

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Direct binding of occupied urokinase receptor (uPAR) to LDL receptor-related protein is required for endocytosis of uPAR and regulation of cell surface urokinase activity

31 March 2020

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Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes

31 March 2020

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Urokinase regulates vitronectin binding by controlling urokinase receptor oligomerization

31 March 2020

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Proteolytic cleavage of the urokinase receptor substitutes for the agonist-induced chemotactic effect

31 March 2020

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31 March 2020

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Regulation of integrin function by the urokinase receptor

31 March 2020

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Requirement of receptor-bound urokinase-type plasminogen activator for integrin alphavbeta5-directed cell migration

31 March 2020

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Urokinase/urokinase receptor and vitronectin/alpha(v)beta(3) integrin induce chemotaxis and cytoskeleton reorganization through different signaling pathways

31 March 2020

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Urokinase receptor (CD87) regulates leukocyte recruitment via beta 2 integrins in vivo.

31 March 2020

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Nonproteolytic role for the urokinase receptor in cellular migration in vivo.

31 March 2020

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Urokinase plasminogen activator receptor, beta 2-integrins, and Src-kinases within a single receptor complex of human monocytes

31 March 2020

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Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling

31 March 2020

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Urokinase-type plasminogen activator receptor (CD87) is a ligand for integrins and mediates cell-cell interaction.

31 March 2020

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Identification of a urokinase receptor-integrin interaction site. Promiscuous regulator of integrin function

31 March 2020

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Urokinase receptors promote beta1 integrin function through interactions with integrin alpha3beta1.

31 March 2020

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EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma

31 March 2020

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The cleavage of the urokinase receptor regulates its multiple functions

31 March 2020

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A urokinase-sensitive region of the human urokinase receptor is responsible for its chemotactic activity.

31 March 2020

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Urokinase-type plasminogen activator stimulates the Ras/Extracellular signal-regulated kinase (ERK) signaling pathway and MCF-7 cell migration by a mechanism that requires focal adhesion kinase, Src, and Shc. Rapid dissociation of GRB2/Sps-Shc compl

31 March 2020

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The fibrinolytic receptor for urokinase activates the G protein-coupled chemotactic receptor FPRL1/LXA4R.

31 March 2020

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Lipid rafts and signal transduction

31 March 2020

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A role for caveolin and the urokinase receptor in integrin-mediated adhesion and signaling

31 March 2020

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Segregation of leading-edge and uropod components into specific lipid rafts during T cell polarization

31 March 2020

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Urokinase receptor is associated with the components of the JAK1/STAT1 signaling pathway and leads to activation of this pathway upon receptor clustering in the human kidney epithelial tumor cell line TCL-598

31 March 2020

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Embryonic fibroblasts that are genetically deficient in low density lipoprotein receptor-related protein demonstrate increased activity of the urokinase receptor system and accelerated migration on vitronectin

31 March 2020

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The very low density lipoprotein receptor regulates urokinase receptor catabolism and breast cancer cell motility in vitro

31 March 2020

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PAI-1 inhibits urokinase-induced chemotaxis by internalizing the urokinase receptor

31 March 2020

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Mannose 6-phosphate/insulin-like growth factor-II receptor targets the urokinase receptor to lysosomes via a novel binding interaction

31 March 2020

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A urokinase receptor-associated protein with specific collagen binding properties

31 March 2020

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Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo.

31 March 2020

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Rac mediates cytoskeletal rearrangements and increased cell motility induced by urokinase-type plasminogen activator receptor binding to vitronectin

31 March 2020

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Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective manner

31 March 2020

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Induction of cell migration by pro-urokinase binding to its receptor: possible mechanism for signal transduction in human epithelial cells

31 March 2020

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Distribution and lateral mobility of the urokinase-receptor complex at the cell surface.

31 March 2020

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Cutting edge: evidence for a signaling partnership between urokinase receptors (CD87) and L-selectin (CD62L) in human polymorphonuclear neutrophils

31 March 2020

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Amyloid (beta)42 activates a G-protein-coupled chemoattractant receptor, FPR-like-1

31 March 2020

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The Jak/Stat pathway and urokinase receptor signaling in human aortic vascular smooth muscle cells.

31 March 2020

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Urokinase receptor mediates mechanical force transfer across the cell surface.

31 March 2020

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Urokinase stimulates human vascular smooth muscle cell migration via a phosphatidylinositol 3-kinase-Tyk2 interaction

31 March 2020

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Domain 1 of the urokinase receptor (uPAR) is required for uPAR-mediated cell binding to vitronectin

31 March 2020

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Urokinase-dependent human vascular smooth muscle cell adhesion requires selective vitronectin phosphorylation by ectoprotein kinase CK2.

31 March 2020

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An autocrine role for urokinase in phorbol ester-mediated differentiation of myeloid cell lines

31 March 2020

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The urokinase plasminogen activator receptor (UPAR) is preferentially induced by nerve growth factor in PC12 pheochromocytoma cells and is required for NGF-driven differentiation.

31 March 2020

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Reduction in surface urokinase receptor forces malignant cells into a protracted state of dormancy

31 March 2020

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Receptor-independent role of urokinase-type plasminogen activator in pericellular plasmin and matrix metalloproteinase proteolysis during vascular wound healing in mice

31 March 2020

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Urokinase receptor-dependent and -independent p56/59(hck) activation state is a molecular switch between myelomonocytic cell motility and adherence

31 March 2020

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The role of proteinases in angiogenesis, heart development, restenosis, atherosclerosis, myocardial ischemia, and stroke: insights from genetic studies

31 March 2020

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Physiological consequences of loss of plasminogen activator gene function in mice

31 March 2020

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The receptor for urokinase-type plasminogen activator is not essential for mouse development or fertility

31 March 2020

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Generation and characterization of urokinase receptor-deficient mice

31 March 2020

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Effects of Disruption of The Plasminogen Gene on Thrombosis, Growth, and Health in Mice

31 March 2020

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Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction

31 March 2020

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Loss of fibrinogen rescues mice from the pleiotropic effects of plasminogen deficiency.

31 March 2020

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Urokinase-type plasminogen activator is effective in fibrin clearance in the absence of its receptor or tissue-type plasminogen activator

31 March 2020

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Development and disease in proteinase-deficient mice: role of the plasminogen, matrix metalloproteinase and coagulation system

31 March 2020

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Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation

31 March 2020

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Reduced transplant arteriosclerosis in plasminogen-deficient mice

31 March 2020

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Urokinase but not tissue plasminogen activator mediates arterial neointima formation in mice

31 March 2020

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Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure

31 March 2020

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Functional overlap between two classes of matrix-degrading proteases in wound healing

31 March 2020

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Impaired wound healing in mice with a disrupted plasminogen gene

31 March 2020

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Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization.

31 March 2020

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The plasminogen activator inhibitor PAI-1 controls in vivo tumor vascularization by interaction with proteases, not vitronectin. Implications for antiangiogenic strategies

31 March 2020

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Impaired arterial neointima formation in mice with disruption of the plasminogen gene

31 March 2020

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Deficiency of urokinase-type plasminogen activator-mediated plasmin generation impairs vascular remodeling during hypoxia-induced pulmonary hypertension in mice

31 March 2020

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Mice deficient in Mac-1 (CD11b/CD18) are less susceptible to cerebral ischemia/reperfusion injury

31 March 2020

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Urokinase receptor-deficient mice have impaired neutrophil recruitment in response to pulmonary Pseudomonas aeruginosa infection

31 March 2020

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Mouse model of myocardial remodelling after ischemia: role of intercellular adhesion molecule-1.

31 March 2020

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Leukocyte adhesion deficiency syndromes: adhesion and tethering defects involving beta 2 integrins and selectin ligands

31 March 2020

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Antigen-driven lymphocyte recruitment to the lung is diminished in the absence of urokinase-type plasminogen activator (uPA) receptor, but is independent of uPA.

31 March 2020

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The urokinase receptor is required for human monocyte chemotaxis in vitro

31 March 2020

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Urokinase receptor is necessary for adequate host defense against pneumococcal pneumonia.

31 March 2020

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Urokinase is required for the pulmonary inflammatory response to Cryptococcus neoformans. A murine transgenic model

31 March 2020

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Leukocyte and endothelial cell adhesion molecules in a chronic murine model of myocardial reperfusion injury

31 March 2020

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Urokinase-urokinase receptor interaction mediates an inhibitory signal for HIV-1 replication

31 March 2020

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Urokinase plasminogen activator receptor (uPAR; CD87) expression on monocytic cells and T cells is modulated by HIV-1 infection

31 March 2020

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Borrelia burgdorferi and other bacterial products induce expression and release of the urokinase receptor (CD87).

31 March 2020

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Functional involvement of urokinase-type plasminogen activator receptor in pemphigus acantholysis

31 March 2020

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Increased expression of the urokinase plasminogen-activator receptor in amyloid beta peptide-treated human brain microglia and in AD brains

31 March 2020

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The murine receptor for urokinase-type plasminogen activator is primarily expressed in tissues actively undergoing remodeling

31 March 2020

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Plasma Urokinase Receptor Levels in Patients With Colorectal Cancer: Relationship to Prognosis

31 March 2020

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Prevention of metastasis by inhibition of the urokinase receptor

31 March 2020

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Autocrine saturation of pro-urokinase receptors on human A431 cells.

31 March 2020

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Peptide-derived antagonists of the urokinase receptor. affinity maturation by combinatorial chemistry, identification of functional epitopes, and inhibitory effect on cancer cell intravasation

31 March 2020

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Role of the matrix metalloproteinase and plasminogen activator-plasmin systems in angiogenesis.

31 March 2020

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Angiogenesis in cancer and other diseases

31 March 2020

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Vessels of death or life.

31 March 2020

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The urokinase plasminogen activator system in angiosarcoma, Kaposi's sarcoma, granuloma pyogenicum, and angioma: an immunohistochemical study

31 March 2020

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Adenovirus-mediated delivery of a uPA/uPAR antagonist suppresses angiogenesis-dependent tumor growth and dissemination in mice

31 March 2020

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Influence of plasminogen activator inhibitor type 1 on choroidal neovascularization

31 March 2020

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Plasminogen activator inhibitor-1 regulates tumor growth and angiogenesis

31 March 2020

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Inhibition of angiogenesis in vivo by plasminogen activator inhibitor-1

31 March 2020

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The pro- or antiangiogenic effect of plasminogen activator inhibitor 1 is dose dependent

31 March 2020

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Urokinase receptor and integrin partnership: coordination of signaling for cell adhesion, migration and growth.

31 March 2020

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Transgenic mouse models in angiogenesis and cardiovascular disease

31 March 2020

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The urokinase plasminogen activator receptor in blood from healthy individuals and patients with cancer

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRM977

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Dimensions Publication ID

31 July 2017

1014993633

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