(Q33558208)

28 July 2017

title

Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor (English)

1 reference

28 July 2017

John G Houston

17

0 references

author name string

Kevin W Gillman

1

1 reference

28 July 2017

John E Starrett

2

1 reference

28 July 2017

Michael F Parker

3

1 reference

28 July 2017

Kai Xie

4

1 reference

28 July 2017

Joanne J Bronson

5

1 reference

28 July 2017

Lawrence R Marcin

6

1 reference

28 July 2017

Kate E McElhone

7

1 reference

28 July 2017

Carl P Bergstrom

8

1 reference

28 July 2017

Robert A Mate

9

1 reference

28 July 2017

Richard Williams

10

1 reference

28 July 2017

Jere E Meredith

11

1 reference

28 July 2017

Catherine R Burton

12

1 reference

28 July 2017

Donna M Barten

13

1 reference

28 July 2017

Jeremy H Toyn

14

1 reference

28 July 2017

Susan B Roberts

15

1 reference

28 July 2017

Kimberley A Lentz

16

1 reference

28 July 2017

Robert Zaczek

18

1 reference

28 July 2017

Charles F Albright

19

1 reference

28 July 2017

Carl P Decicco

20

1 reference

28 July 2017

John E Macor

21

1 reference

28 July 2017

Richard E Olson

22

1 reference

28 July 2017

language of work or name

1 reference

22 March 2010

1 reference

ACS Medicinal Chemistry Letters

28 July 2017

published in

1 reference

28 July 2017

volume

1

1 reference

28 July 2017

issue

3

1 reference

28 July 2017

page(s)

120-124

1 reference

The amyloid-beta rise and gamma-secretase inhibitor potency depend on the level of substrate expression

28 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007960

Deciphering the molecular basis of memory failure in Alzheimer's disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007960

Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007960

Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007960

Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007960

Alzheimer's disease: genes, proteins, and therapy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007960

Notch signaling: a dance of proteins changing partners

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007960

Notch signaling: cell fate control and signal integration in development

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007960

Novel benzodiazepine receptor partial agonists: oxadiazolylimidazobenzodiazepines

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007960

Synthesis and biological activity of 1,2,4-oxadiazole derivatives: highly potent and efficacious agonists for cortical muscarinic receptors.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007960

Studies on the pharmacokinetics and metabolism of a gamma-secretase inhibitor BMS-299897, and exploratory investigation of CYP enzyme induction.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007960

Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007960

Safety, tolerability, and effects on plasma and cerebrospinal fluid amyloid-beta after inhibition of gamma-secretase

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007960

Reductions in beta-amyloid concentrations in vivo by the gamma-secretase inhibitors BMS-289948 and BMS-299897.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007960

Dynamics of {beta}-amyloid reductions in brain, cerebrospinal fluid, and plasma of {beta}-amyloid precursor protein transgenic mice treated with a {gamma}-secretase inhibitor

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007960

Orally active GPIIb/IIIa antagonists: synthesis and biological activities of masked amidines as prodrugs of 2-[(3S)-4.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007960

Amino-caprolactam derivatives as gamma-secretase inhibitors

31 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24900185

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/ML1000239

1 reference

28 July 2017

1 reference

28 July 2017

1 reference