(Q33559671)

28 July 2017

title

Metal-free ALS variants of dimeric human Cu,Zn-superoxide dismutase have enhanced populations of monomeric species (English)

1 reference

amyotrophic lateral sclerosis

28 July 2017

main subject

1 reference

Can Kayatekin

3

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author name string

Anna-Karin E Svensson

1

1 reference

28 July 2017

Osman Bilsel

2

1 reference

28 July 2017

Jessica A Adefusika

4

1 reference

28 July 2017

Jill A Zitzewitz

5

1 reference

28 July 2017

C Robert Matthews

6

1 reference

28 July 2017

language of work or name

English

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publication date

9 April 2010

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28 July 2017

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28 July 2017

volume

5

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28 July 2017

issue

4

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28 July 2017

page(s)

e10064

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Creative Commons Attribution 4.0 International

28 July 2017

copyright license

start time

9 April 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Transient structural distortion of metal-free Cu/Zn superoxide dismutase triggers aberrant oligomerization

21 June 2018

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Functional features cause misfolding of the ALS-provoking enzyme SOD1

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21 June 2018

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21 June 2018

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Zinc binding modulates the entire folding free energy surface of human Cu,Zn superoxide dismutase

21 June 2018

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Denaturational stress induces formation of zinc-deficient monomers of Cu,Zn superoxide dismutase: implications for pathogenesis in amyotrophic lateral sclerosis.

21 June 2018

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Protein aggregation and protein instability govern familial amyotrophic lateral sclerosis patient survival

21 June 2018

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Complete loss of post-translational modifications triggers fibrillar aggregation of SOD1 in the familial form of amyotrophic lateral sclerosis

21 June 2018

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Metal-free superoxide dismutase forms soluble oligomers under physiological conditions: a possible general mechanism for familial ALS

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Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria

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Aberrantly increased hydrophobicity shared by mutants of Cu,Zn-superoxide dismutase in familial amyotrophic lateral sclerosis.

21 June 2018

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Copper-zinc superoxide dismutase and amyotrophic lateral sclerosis

21 June 2018

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Folding of human superoxide dismutase: disulfide reduction prevents dimerization and produces marginally stable monomers

21 June 2018

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21 June 2018

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Cu/Zn superoxide dismutase mutants associated with amyotrophic lateral sclerosis show enhanced formation of aggregates in vitro

21 June 2018

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21 June 2018

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21 June 2018

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Dynamic properties of the G93A mutant of copper-zinc superoxide dismutase as detected by NMR spectroscopy: implications for the pathology of familial amyotrophic lateral sclerosis

21 June 2018

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Common denominator of Cu/Zn superoxide dismutase mutants associated with amyotrophic lateral sclerosis: decreased stability of the apo state

21 June 2018

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Familial amyotrophic lateral sclerosis mutants of copper/zinc superoxide dismutase are susceptible to disulfide reduction

21 June 2018

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21 June 2018

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Decreased metallation and activity in subsets of mutant superoxide dismutases associated with familial amyotrophic lateral sclerosis.

21 June 2018

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From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852398

Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

21 June 2018

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21 June 2018

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21 June 2018

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Denaturant m values and heat capacity changes: relation to changes in accessible surface areas of protein unfolding

21 June 2018

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Determination and analysis of the 2 A-structure of copper, zinc superoxide dismutase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852398

Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein)

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852398

Evolution of CuZn superoxide dismutase and the Greek key beta-barrel structural motif

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852398

Contribution of conformational stability and reversibility of unfolding to the increased thermostability of human and bovine superoxide dismutase mutated at free cysteines.

21 June 2018

1 reference

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Thermostabilization of recombinant human and bovine CuZn superoxide dismutases by replacement of free cysteines

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852398

Unfolding and folding kinetics of amyotrophic lateral sclerosis-associated mutant Cu,Zn superoxide dismutases

21 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0010064

An immunological epitope selective for pathological monomer-misfolded SOD1 in ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0010064

Mechanism and thermodynamics of guanidinium chloride-induced denaturation of ALS-associated mutant Cu,Zn superoxide dismutases

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0010064

Minute quantities of misfolded mutant superoxide dismutase-1 cause amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0010064

Variable Metallation of Human Superoxide Dismutase: Atomic Resolution Crystal Structures of Cu–Zn, Zn–Zn and As-isolated Wild-type Enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0010064

Preformed secondary structure drives the association reaction of GCN4-p1, a model coiled-coil system

21 January 2018

1 reference

12 December 2020

Effect of point mutations on the folding of globular proteins

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12 December 2020

Decreased zinc affinity of amyotrophic lateral sclerosis-associated superoxide dismutase mutants leads to enhanced catalysis of tyrosine nitration by peroxynitrite

1 reference

12 December 2020

Reactions of hydrogen peroxide with familial amyotrophic lateral sclerosis mutant human copper-zinc superoxide dismutases studied by pulse radiolysis

1 reference

12 December 2020

Disulphide-reduced superoxide dismutase-1 in CNS of transgenic amyotrophic lateral sclerosis models

1 reference

12 December 2020

Equilibrium thermodynamic analysis of amyotrophic lateral sclerosis-associated mutant apo Cu,Zn superoxide dismutases

1 reference

12 December 2020

Mapping the folding free energy surface for metal-free human Cu,Zn superoxide dismutase

1 reference

12 December 2020

The coupling between disulphide status, metallation and dimer interface strength in Cu/Zn superoxide dismutase

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0010064

Identifiers

DOI

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28 July 2017

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28 July 2017

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