(Q33563777)

28 July 2017

title

Hepcidin antagonists for potential treatments of disorders with hepcidin excess (English)

1 reference

28 July 2017

Paolo Arosio

5

0 references

author name string

Maura Poli

1

1 reference

28 July 2017

Michela Asperti

2

1 reference

28 July 2017

Paola Ruzzenenti

3

1 reference

28 July 2017

Maria Regoni

4

1 reference

28 July 2017

publication date

28 April 2014

1 reference

Frontiers in Pharmacology

28 July 2017

published in

1 reference

28 July 2017

volume

5

1 reference

28 July 2017

page(s)

86

1 reference

Glycol-split nonanticoagulant heparins are inhibitors of hepcidin expression in vitro and in vivo.

28 July 2017

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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A hepcidin lowering agent mobilizes iron for incorporation into red blood cells in an adenine-induced kidney disease model of anemia in rats.

21 June 2018

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High-throughput screening of small molecules identifies hepcidin antagonists

21 June 2018

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The murine growth differentiation factor 15 is not essential for systemic iron homeostasis in phlebotomized mice.

21 June 2018

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Neogenin interacts with matriptase-2 to facilitate hemojuvelin cleavage

21 June 2018

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Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination

21 June 2018

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Update on safety of ESAs in cancer-induced anemia

21 June 2018

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Hepcidin and iron homeostasis

21 June 2018

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Targeting the hepcidin-ferroportin axis to develop new treatment strategies for anemia of chronic disease and anemia of inflammation

21 June 2018

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Pharmacological suppression of hepcidin increases macrophage cholesterol efflux and reduces foam cell formation and atherosclerosis

21 June 2018

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Hepcidin is involved in iron regulation in the ischemic brain

21 June 2018

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Expression and localization of mitochondrial ferritin mRNA in Alzheimer's disease cerebral cortex

21 June 2018

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The specificities of small molecule inhibitors of the TGFß and BMP pathways

21 June 2018

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Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats

21 June 2018

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Comparison of changes in gene expression of transferrin receptor-1 and other iron-regulatory proteins in rat liver and brain during acute-phase response

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation

21 June 2018

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The bone morphogenetic protein-hepcidin axis as a therapeutic target in inflammatory bowel disease

21 June 2018

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SST0001, a chemically modified heparin, inhibits myeloma growth and angiogenesis via disruption of the heparanase/syndecan-1 axis

21 June 2018

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Ophthalmic drug delivery systems for the treatment of retinal diseases: basic research to clinical applications

21 June 2018

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Hepcidin and disorders of iron metabolism

21 June 2018

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Heparan sulfate acts as a bone morphogenetic protein coreceptor by facilitating ligand-induced receptor hetero-oligomerization

21 June 2018

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Detection, evaluation, and management of iron-restricted erythropoiesis

21 June 2018

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BMP6 treatment compensates for the molecular defect and ameliorates hemochromatosis in Hfe knockout mice

21 June 2018

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In anemia of multiple myeloma, hepcidin is induced by increased bone morphogenetic protein 2.

21 June 2018

1 reference

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Down-regulation of hepcidin resulting from long-term treatment with an anti-IL-6 receptor antibody (tocilizumab) improves anemia of inflammation in multicentric Castleman disease

21 June 2018

1 reference

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Transferrin receptor 2 and HFE regulate furin expression via mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/Erk) signaling. Implications for transferrin-dependent hepcidin regulation.

21 June 2018

1 reference

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Siltuximab, a novel anti-interleukin-6 monoclonal antibody, for Castleman's disease

21 June 2018

1 reference

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Two to tango: regulation of Mammalian iron metabolism

21 June 2018

1 reference

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Delivery of siRNA therapeutics: barriers and carriers

21 June 2018

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Heparin-derived heparan sulfate mimics to modulate heparan sulfate-protein interaction in inflammation and cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

A novel small-molecule disrupts Stat3 SH2 domain-phosphotyrosine interactions and Stat3-dependent tumor processes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Role of hepcidin in murine brain iron metabolism

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

The RGM/DRAGON family of BMP co-receptors

21 June 2018

1 reference

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Heparan sulfate 2-O-sulfotransferase is required for triglyceride-rich lipoprotein clearance

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Brain iron homeostasis, the choroid plexus, and localization of iron transport proteins.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Functional analysis and theoretical modeling of ferroportin reveals clustering of mutations according to phenotype.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Animal models of anemia of inflammation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Hepcidin revisited, disulfide connectivity, dynamics, and structure

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

The molecular basis of hepcidin-resistant hereditary hemochromatosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Molecular mechanisms of the defective hepcidin inhibition in TMPRSS6 mutations associated with iron-refractory iron deficiency anemia

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

BMP type I receptor inhibition reduces heterotopic [corrected] ossification

21 June 2018

1 reference

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A potent anti-carcinoma and anti-acute myeloblastic leukemia agent, AG490.

21 June 2018

1 reference

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Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors

21 June 2018

1 reference

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Fine tuning of hepcidin expression by positive and negative regulators

21 June 2018

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Blood-neural barrier: its diversity and coordinated cell-to-cell communication

21 June 2018

1 reference

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The serine protease TMPRSS6 is required to sense iron deficiency

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Pro-protein convertases control the maturation and processing of the iron-regulatory protein, RGMc/hemojuvelin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Neurodegeneration with brain iron accumulation: from genes to pathogenesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Heparan sulfate proteoglycans (HSPGs) modulate BMP2 osteogenic bioactivity in C2C12 cells.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Regulation of iron metabolism by hepcidin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Interaction of hemojuvelin with neogenin results in iron accumulation in human embryonic kidney 293 cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Biotechnological engineering of heparin/heparan sulphate: a novel area of multi-target drug discovery.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

The molecular basis of ferroportin-linked hemochromatosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Functional consequences of ferroportin 1 mutations

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Zymosan-induced generalized inflammation: experimental studies into mechanisms leading to multiple organ dysfunction syndrome

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Lipocalins in drug discovery: from natural ligand-binding proteins to "anticalins".

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Iron, brain ageing and neurodegenerative disorders

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Heparan sulfate is required for bone morphogenetic protein-7 signaling

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Erythropoietin resistance: the role of inflammation and pro-inflammatory cytokines

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Chemical derivatization as a strategy to study structure-activity relationships of glycosaminoglycans

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Brain iron pathways and their relevance to Parkinson's disease.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Hepcidin: a putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Heparan sulfate: decoding a dynamic multifunctional cell regulator

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Hepcidin, a urinary antimicrobial peptide synthesized in the liver

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

The lipocalin protein family: structure and function

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

Arthritis in rats after systemic injection of streptococcal cells or cell walls

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4009444

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

21 June 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2014.00086

Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2014.00086

Iron: a pathological mediator of Alzheimer disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2014.00086

Oncostatin M is a potent inducer of hepcidin, the iron regulatory hormone.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2014.00086

Ferritin subunits in CSF are decreased in restless legs syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2014.00086

A fully human anti-hepcidin antibody modulates iron metabolism in both mice and nonhuman primates

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2014.00086

Natural and synthetic STAT3 inhibitors reduce hepcidin expression in differentiated mouse hepatocytes expressing the active phosphorylated STAT3 form

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2014.00086

Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2014.00086

Phlebotomies or erythropoietin injections allow mobilization of iron stores in a mouse model mimicking intensive care anemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2014.00086

Heparin: a potent inhibitor of hepcidin expression in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2014.00086

Organization and expression analysis of the zebrafish hepcidin gene, an antimicrobial peptide gene conserved among vertebrates.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2014.00086

High hepcidin level accounts for the nigral iron accumulation in acute peripheral iron intoxication rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2014.00086

High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2014.00086

Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implications.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2014.00086

Distribution of the iron-regulating protein hepcidin in the murine central nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2014.00086

AG490: an inhibitor of hepcidin expression in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2014.00086

Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia

21 January 2018

1 reference

12 December 2020

Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis

1 reference

12 December 2020

Hepcidin regulation by innate immune and infectious stimuli

1 reference

12 December 2020

Tocilizumab, a humanized anti-interleukin-6 receptor antibody, improved anemia in monkey arthritis by suppressing IL-6-induced hepcidin production

1 reference

12 December 2020

STAT3 signaling within hepatocytes is required for anemia of inflammation in vivo

1 reference

12 December 2020

Identifiers

DOI

10.3389/FPHAR.2014.00086

1 reference

28 July 2017

1 reference

28 July 2017

1 reference