(Q33564338)

28 July 2017

title

Mitaplatin, a potent fusion of cisplatin and the orphan drug dichloroacetate (English)

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28 July 2017

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2

Stephen J Lippard

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28 July 2017

Shanta Dhar

1

1 reference

28 July 2017

language of work or name

English

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publication date

10 December 2009

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Proceedings of the National Academy of Sciences of the United States of America

28 July 2017

published in

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28 July 2017

volume

106

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28 July 2017

issue

52

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28 July 2017

page(s)

22199-22204

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Mitochondrial uncoupling and the Warburg effect: molecular basis for the reprogramming of cancer cell metabolism

28 July 2017

cites work

1 reference

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Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles

21 June 2018

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Targeted single-wall carbon nanotube-mediated Pt(IV) prodrug delivery using folate as a homing device

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2799774

Dichloroacetate (DCA) sensitizes both wild-type and over expressing Bcl-2 prostate cancer cells in vitro to radiation

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2799774

Dichloroacetate induces apoptosis in endometrial cancer cells.

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2799774

Current status and future prospects for satraplatin, an oral platinum analogue

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2799774

Conjugated platinum(IV)-peptide complexes for targeting angiogenic tumor vasculature

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2799774

Metabolic targeting of hypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2799774

Mitochondria as a critical target of the chemotheraputic agent cisplatin in head and neck cancer.

21 June 2018

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A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2799774

Cancer's molecular sweet tooth and the Warburg effect.

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2799774

Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2799774

Update of the preclinical situation of anticancer platinum complexes: novel design strategies and innovative analytical approaches

21 June 2018

1 reference

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Cellular processing of platinum anticancer drugs

21 June 2018

1 reference

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Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia.

21 June 2018

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Why do cancers have high aerobic glycolysis?

21 June 2018

1 reference

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Mitochondria as cancer drug targets.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2799774

Cytochrome C-mediated apoptosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2799774

Cisplatin: mode of cytotoxic action and molecular basis of resistance

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2799774

Medicinal and Genetic Approaches to the Treatment of Mitochondrial Disease

21 June 2018

1 reference

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On the Origin of Cancer Cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2799774

Efficacy of dichloroacetate as a lactate-lowering drug

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2799774

Characterization of a novel metabolic strategy used by drug-resistant tumor cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2799774

Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

21 June 2018

1 reference

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21 June 2018

The Hallmarks of Cancer

1 reference

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Revolution in mitochondrial medicine

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2799774

Association between cisplatin resistance and mutation of p53 gene and reduced bax expression in ovarian carcinoma cell systems

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2799774

A new method for the cytofluorimetric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolcarbocyanine iodide (JC-1).

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2799774

Platinum Compounds: a New Class of Potent Antitumour Agents

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2799774

The pharmacology of dichloroacetate

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2799774

Connected to death: the (unexpurgated) mitochondrial pathway of apoptosis.

21 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0912276106

Cancer patients opt for unapproved drug.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0912276106

Structure, Recognition, and Processing of Cisplatin-DNA Adducts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0912276106

Adduct-specific monoclonal antibodies for the measurement of cisplatin-induced DNA lesions in individual cell nuclei

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0912276106

Resistance of mitochondrial DNA-depleted cells against cell death: role of mitochondrial superoxide dismutase

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0912276106

Carboxylation of Kinetically Inert Platinum(IV) Hydroxy Complexes. An Entr.acte.ee into Orally Active Platinum(IV) Antitumor Agents

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20007777

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Tetramethyl rhodamine methyl ester (TMRM) is suitable for cytofluorometric measurements of mitochondrial membrane potential in cells treated with digitonin

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20007777

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The cellular distribution and oxidation state of platinum(II) and platinum(IV) antitumour complexes in cancer cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20007777

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0912276106

1 reference

28 July 2017

0 references

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28 July 2017

1 reference