(Q33581165)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24569690%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

title

Recombinant human interleukin-1 receptor antagonist in severe traumatic brain injury: a phase II randomized control trial (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24569690%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

main subject

phase II clinical trial

0 references

traumatic brain injury

0 references

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24569690%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Keri L. Carpenter

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24569690%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

author name string

Mathew R Guilfoyle

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24569690%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

John D Pickard

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24569690%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

David K Menon

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24569690%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Peter J Hutchinson

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24569690%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

publication date

26 February 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24569690%20AND%20SRC:MED&resulttype=core&format=json

Journal of Cerebral Blood Flow & Metabolism

8 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24569690%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

volume

34

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24569690%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24569690%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

page(s)

845-851

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24569690%20AND%20SRC:MED&resulttype=core&format=json

Cerebral microdialysis in clinical studies of drugs: pharmacokinetic applications

8 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013762

Safety, tolerability, pharmacokinetics and pharmacodynamics of GSK2239633, a CC-chemokine receptor 4 antagonist, in healthy male subjects: results from an open-label and from a randomised study

14 July 2018

1 reference

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Design and synthesis of a series of pyrido[2,3-d]pyrimidine derivatives as CCR4 antagonists.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013762

Principal component analysis of the cytokine and chemokine response to human traumatic brain injury

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013762

Tissue microenvironments define and get reinforced by macrophage phenotypes in homeostasis or during inflammation, repair and fibrosis.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013762

Cytokines and innate inflammation in the pathogenesis of human traumatic brain injury.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013762

Ccl22/MDC, is a prostaglandin dependent pyrogen, acting in the anterior hypothalamus to induce hyperthermia via activation of brown adipose tissue

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013762

The cytokine response to human traumatic brain injury: temporal profiles and evidence for cerebral parenchymal production.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013762

Intravenous anakinra can achieve experimentally effective concentrations in the central nervous system within a therapeutic time window: results of a dose-ranging study

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013762

CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013762

Neutralization of interleukin-1beta modifies the inflammatory response and improves histological and cognitive outcome following traumatic brain injury in mice.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013762

Boosting T-cell immunity as a therapeutic approach for neurodegenerative conditions: the role of innate immunity

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013762

Classification of traumatic brain injury for targeted therapies

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013762

Traumatic brain injury: intensive care management

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013762

The role of T helper cells in neuroprotection and regeneration

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013762

A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013762

The chemokine system in diverse forms of macrophage activation and polarization

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013762

Macrophage-derived chemokine (MDC).

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013762

Interleukin-1beta and the interleukin-1 receptor antagonist act in the striatum to modify excitotoxic brain damage in the rat.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013762

Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. The Interleukin-1 Receptor Antagonist Sepsis Investigator Group

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013762

Attenuation of stroke size in rats using an adenoviral vector to induce overexpression of interleukin-1 receptor antagonist in brain

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013762

Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013762

Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013762

Neutralization of interleukin-1β reduces cerebral edema and tissue loss and improves late cognitive outcome following traumatic brain injury in mice.

14 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2014.23

Improved recovery and delayed cytokine induction after closed head injury in mice with central overexpression of the secreted isoform of the interleukin-1 receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2014.23

Neuroinflammation and both cytotoxic and vasogenic edema are reduced in interleukin-1 type 1 receptor-deficient mice conferring neuroprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2014.23

Exploring new routes for neuroprotective drug development in traumatic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2014.23

Interleukin-1 receptor antagonist penetrates human brain at experimentally therapeutic concentrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2014.23

Microdialysis of cytokines: methodological considerations, scanning electron microscopy, and determination of relative recovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2014.23

Pharmacokinetics of anakinra in subjects with different levels of renal function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2014.23

Immune response deviation and enhanced expression of chemokine receptor CCR4 in TBI patients due to unknown serum factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2014.23

An investigation of auto-reactivity after head injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2014.23

Temporal profile of release of interleukin-1beta in neurotrauma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2014.23

Continuous Versus Intermittent Cerebrospinal Fluid Drainage after Severe Traumatic Brain Injury in Children: Effect on Biochemical Markers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2014.23

Small molecule antagonists of the CC chemokine receptor 4 (CCR4)

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24569690

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

T lymphocyte trafficking: a novel target for neuroprotection in traumatic brain injury

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24569690

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/JCBFM.2014.23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24569690%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24569690%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

PubMed publication ID

24569690

1 reference