(Q41061299)

English

Safety, tolerability, pharmacokinetics and pharmacodynamics of GSK2239633, a CC-chemokine receptor 4 antagonist, in healthy male subjects: results from an open-label and from a randomised study

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

26 September 2017

Safety, tolerability, pharmacokinetics and pharmacodynamics of GSK2239633, a CC-chemokine receptor 4 antagonist, in healthy male subjects: results from an open-label and from a randomised study (English)

1 reference

Europe PubMed Central

PMC publication ID

26 September 2017

pharmacokinetics

1 reference

based on heuristic

inferred from title

pharmacodynamics

1 reference

based on heuristic

inferred from title

object named as

Graeme Young

8

1 reference

ORCID Public Data File 2021

author name string

Anthony Cahn

1

1 reference

Europe PubMed Central

PMC publication ID

26 September 2017

Simon Hodgson

2

1 reference

Europe PubMed Central

PMC publication ID

26 September 2017

Robert Wilson

3

1 reference

Europe PubMed Central

PMC publication ID

26 September 2017

Jonathan Robertson

4

1 reference

Europe PubMed Central

PMC publication ID

26 September 2017

Joanna Watson

5

1 reference

Europe PubMed Central

PMC publication ID

26 September 2017

Misba Beerahee

6

1 reference

Europe PubMed Central

PMC publication ID

26 September 2017

Steve C Hughes

7

1 reference

Europe PubMed Central

PMC publication ID

26 September 2017

Rebecca Graves

9

1 reference

Europe PubMed Central

PMC publication ID

26 September 2017

David Hall

10

1 reference

Europe PubMed Central

PMC publication ID

26 September 2017

Sjoerd van Marle

11

1 reference

Europe PubMed Central

PMC publication ID

26 September 2017

Roberto Solari

12

1 reference

Europe PubMed Central

PMC publication ID

26 September 2017

publication date

28 February 2013

1 reference

Europe PubMed Central

PMC publication ID

26 September 2017

BMC pharmacology & toxicology

1 reference

Europe PubMed Central

PMC publication ID

26 September 2017

14

1 reference

Europe PubMed Central

PMC publication ID

26 September 2017

14

1 reference

Europe PubMed Central

PMC publication ID

26 September 2017

copyright license

Creative Commons Attribution 2.0 Generic

28 February 2013

1 reference

April 2022 Public Data File from Crossref

Creative Commons Attribution 2.0 Generic

0 references

copyright status

1 reference

April 2022 Public Data File from Crossref

Monoclonal antibodies for the treatment of asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599276

26 September 2017

The role of cytokines in atopic asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599276

26 September 2017

Targeting chemokine receptors in allergic disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599276

26 September 2017

CC chemokine receptor 4 (CCR4) in human allergen-induced late nasal responses.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599276

26 September 2017

Toward the discovery of vaccine adjuvants: coupling in silico screening and in vitro analysis of antagonist binding to human and mouse CCR4 receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599276

26 September 2017

Novel CC chemokine receptor 4 antagonist RS-1154 inhibits ovalbumin-induced ear swelling in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599276

26 September 2017

Inhibitory effect of the new orally active CCR4 antagonist K327 on CCR4+CD4+ T cell migration into the lung of mice with ovalbumin-induced lung allergic inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599276

26 September 2017

Immunobiology of asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599276

26 September 2017

Immunomodulators in the treatment of asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599276

26 September 2017

Mast cells and eosinophils: the two key effector cells in allergic inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599276

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599276

26 September 2017

The cytokine network in asthma and chronic obstructive pulmonary disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599276

26 September 2017

In silico identified CCR4 antagonists target regulatory T cells and exert adjuvant activity in vaccination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599276

26 September 2017

Immunology of asthma and chronic obstructive pulmonary disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599276

26 September 2017

Natural regulatory T cells: mechanisms of suppression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599276

26 September 2017

Chemokine receptors as therapeutic targets in chronic obstructive pulmonary disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599276

26 September 2017

Thymic stromal lymphopoietin: master switch for allergic inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599276

26 September 2017

The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599276

26 September 2017

A Th2 chemokine, TARC, produced by keratinocytes may recruit CLA+CCR4+ lymphocytes into lesional atopic dermatitis skin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599276

26 September 2017

Inducible expression of a Th2-type CC chemokine thymus- and activation-regulated chemokine by human bronchial epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599276

26 September 2017

Overproduction of Th2-specific chemokines in NC/Nga mice exhibiting atopic dermatitis-like lesions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599276

26 September 2017

Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599276

26 September 2017

Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599276

26 September 2017

Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599276

26 September 2017

The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599276

26 September 2017

Demonstration of TARC and CCR4 mRNA expression and distribution using in situ RT-PCR in the lesional skin of atopic dermatitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599276

14 June 2018

A CCR4 antagonist combined with vaccines induces antigen-specific CD8+ T cells and tumor immunity against self antigens.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599276

19 August 2018

RS-1748, a novel CC chemokine receptor 4 antagonist, inhibits ovalbumin-induced airway inflammation in guinea pigs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599276

19 August 2018

International Conference on Harmonisation; Guidance on M3(R2) Nonclinical Safety Studies for the Conduct of Human Clinical Trials and Marketing Authorization for Pharmaceuticals; availability. Notice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599276

19 August 2018

Chemokine receptor 4 plays a key role in T cell recruitment into the airways of asthmatic patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599276

19 August 2018

Declaration of Helsinki. Ethical principles for medical research involving human subjects.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599276

19 August 2018

CCR4 ligands are up-regulated in the airways of atopic asthmatics after segmental allergen challenge

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599276

19 August 2018

Release of both CCR4-active and CXCR3-active chemokines during human allergic pulmonary late-phase reactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599276

19 August 2018

IL-4–expressing bronchoalveolar T cells from asthmatic and healthy subjects preferentially express CCR3 and CCR4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599276

1 October 2018

Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine

1 reference

https://pubmed.ncbi.nlm.nih.gov/23448278

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I study of KW-0761, a defucosylated humanized anti-CCR4 antibody, in relapsed patients with adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/23448278

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lead optimisation of the N1 substituent of a novel series of indazole arylsulfonamides as CCR4 antagonists and identification of a candidate for clinical investigation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23448278

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/23448278

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/23448278

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/2050-6511-14-14

1 reference

Europe PubMed Central

PMC publication ID

26 September 2017

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

26 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

26 September 2017

ResearchGate publication ID

0 references

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