(Q33581333)

28 July 2017

Roscovitine binds to novel L-channel (CaV1.2) sites that separately affect activation and inactivation (English)

1 reference

28 July 2017

Keith S Elmslie

6

0 references

author name string

Viktor Yarotskyy

1

1 reference

28 July 2017

Guofeng Gao

2

1 reference

28 July 2017

Lei Du

3

1 reference

28 July 2017

Sindura B Ganapathi

4

1 reference

28 July 2017

Blaise Z Peterson

5

1 reference

28 July 2017

language of work or name

English

0 references

publication date

2 November 2009

1 reference

Journal of Biological Chemistry

28 July 2017

1 reference

28 July 2017

285

1 reference

28 July 2017

1

1 reference

28 July 2017

43-53

1 reference

State-dependent block of HERG potassium channels by R-roscovitine: implications for cancer therapy

28 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804190

The Timothy syndrome mutation of cardiac CaV1.2 (L-type) channels: multiple altered gating mechanisms and pharmacological restoration of inactivation.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804190

Roscovitine, a cyclin-dependent kinase inhibitor, affects several gating mechanisms to inhibit cardiac L-type (Ca(V)1.2) calcium channels

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804190

Calcium and arrhythmogenesis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804190

Roscovitine-activated HIP2 kinase induces phosphorylation of wt p53 at Ser-46 in human MCF-7 breast cancer cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804190

A phase I trial of the selective oral cyclin-dependent kinase inhibitor seliciclib (CYC202; R-Roscovitine), administered twice daily for 7 days every 21 days

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804190

Roscovitine differentially affects CaV2 and Kv channels by binding to the open state.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804190

Molecular physiology of cardiac repolarization

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804190

In vitro and in vivo pharmacokinetic-pharmacodynamic relationships for the trisubstituted aminopurine cyclin-dependent kinase inhibitors olomoucine, bohemine and CYC202.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804190

Slowed N-type calcium channel (CaV2.2) deactivation by the cyclin-dependent kinase inhibitor roscovitine.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804190

Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804190

Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804190

L-type Ca2+ channels in Ca2+ channelopathies

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804190

Chemical inhibitors of cyclin-dependent kinases

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804190

Dissecting the functional role of different isoforms of the L-type Ca2+ channel.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804190

Calcium channel blockers in the treatment of disease.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804190

Functional roles of cytoplasmic loops and pore lining transmembrane helices in the voltage-dependent inactivation of HVA calcium channels.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804190

Roscovitine and other purines as kinase inhibitors. From starfish oocytes to clinical trials

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804190

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804190

Calcium and cardiac rhythms: physiological and pathophysiological

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804190

Critical determinants of Ca(2+)-dependent inactivation within an EF-hand motif of L-type Ca(2+) channels

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804190

Pharmacology, structure and function of cardiac L-type Ca(2+) channels

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804190

Cardiac ionic currents and acute ischemia: from channels to arrhythmias

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804190

Molecular determinants of drug binding and action on L-type calcium channels

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804190

Efficacy and safety of a once daily graded-release diltiazem formulation in essential hypertension

14 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.076448

Assessment of the efficacy, optimal dosage, and safety of diltiazem in early treatment of unstable angina pectoris

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.076448

Effects of nicardipine on coronary, vertebral and renal arterial flows in patients with essential hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.076448

Roscovitine inhibits ongoing DNA synthesis in human cervical cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.076448

Roscovitine: a novel regulator of P/Q-type calcium channels and transmitter release in central neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.076448

The separation of antagonist from agonist effects of trisubstituted purines on CaV2.2 (N-type) channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.076448

A calcium antagonist vs a non-calcium antagonist hypertension treatment strategy for patients with coronary artery disease. The International Verapamil-Trandolapril Study (INVEST): a randomized controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.076448

Effects of L-type Ca2+ channel antagonism on ventricular arrhythmogenesis in murine hearts containing a modification in the Scn5a gene modelling human long QT syndrome 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.076448

Efficacy of conventional and sustained-release verapamil in stable angina pectoris

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.076448

Structural basis of drug binding to L Ca2+ channels

21 January 2018

1 reference

12 December 2020

The effects of presynaptic calcium channel modulation by roscovitine on transmitter release at the adult frog neuromuscular junction

1 reference

12 December 2020

Calmodulin is the Ca2+ sensor for Ca2+ -dependent inactivation of L-type calcium channels

1 reference

12 December 2020

In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-roscovitine)

1 reference

12 December 2020

Transfer of 1,4-dihydropyridine sensitivity from L-type to class A (BI) calcium channels

1 reference

12 December 2020

Ca2+ enhances U-type inactivation of N-type (CaV2.2) calcium current in rat sympathetic neurons

1 reference

12 December 2020

Efficacy of nicardipine in angina pectoris

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M109.076448

1 reference

28 July 2017

1 reference

28 July 2017

1 reference