(Q33585541)

28 July 2017

title

Thrombin induces tumor invasion through the induction and association of matrix metalloproteinase-9 and beta1-integrin on the cell surface (English)

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28 July 2017

1 reference

Ernst Lengyel

8

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author name string

A Reza Radjabi

1

1 reference

28 July 2017

Kenjiro Sawada

2

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28 July 2017

Sujatha Jagadeeswaran

3

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28 July 2017

Alfred Eichbichler

4

1 reference

28 July 2017

Hilary A Kenny

5

1 reference

28 July 2017

Anthony Montag

6

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28 July 2017

Katharina Bruno

7

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28 July 2017

publication date

29 November 2007

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Journal of Biological Chemistry

28 July 2017

language of work or name

English

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published in

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28 July 2017

volume

283

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28 July 2017

issue

5

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28 July 2017

page(s)

2822-2834

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A novel orthotopic murine model provides insights into cellular and molecular characteristics contributing to human osteosarcoma.

28 July 2017

cites work

1 reference

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Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function

21 June 2018

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Reciprocal interactions between adhesion receptor signaling and MMP regulation

21 June 2018

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Effect of anticoagulant drugs in cancer

21 June 2018

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Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding.

21 June 2018

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Protease-activated receptors (PAR1 and PAR2) contribute to tumor cell motility and metastasis

21 June 2018

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Role of endogenous thrombin in tumor implantation, seeding, and spontaneous metastasis

21 June 2018

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Peptide inhibition of catalytic and noncatalytic activities of matrix metalloproteinase-9 blocks tumor cell migration and invasion.

21 June 2018

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Activated integrin alphavbeta3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells

21 June 2018

1 reference

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Cell surface association of matrix metalloproteinase-9 (gelatinase B).

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805198

ECM regulates MT1-MMP localization with beta1 or alphavbeta3 integrins at distinct cell compartments modulating its internalization and activity on human endothelial cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805198

Integrin activation and structural rearrangement

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805198

Thrombin signalling and protease-activated receptors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805198

The alpha 3 beta 1 integrin is associated with mammary carcinoma cell metastasis, invasion, and gelatinase B (MMP-9) activity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805198

Matrix metalloproteinases: biologic activity and clinical implications

21 June 2018

1 reference

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Tumor targeting with a selective gelatinase inhibitor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805198

Role of thrombin receptor in breast cancer invasiveness

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805198

Thrombin receptor overexpression in malignant and physiological invasion processes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805198

Disruption of Angiogenesis by PEX, a Noncatalytic Metalloproteinase Fragment with Integrin Binding Activity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805198

Regulation of 92 kDa type IV collagenase expression by the jun aminoterminal kinase- and the extracellular signal-regulated kinase-dependent signaling cascades

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805198

Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805198

Stimulation of 92-kDa gelatinase B promoter activity by ras is mitogen-activated protein kinase kinase 1-independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP-1 sequences.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805198

A requirement for Ras protein function in thrombin-stimulated mitogenesis in astrocytoma cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805198

Enhancement of the expression of urokinase-type plasminogen activator from PC-3 human prostate cancer cells by thrombin.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805198

Induction of M(r) 92,000 type IV collagenase expression in a squamous cell carcinoma cell line by fibroblasts.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805198

Involvement of a mitogen-activated protein kinase signaling pathway in the regulation of urokinase promoter activity by c-Ha-ras.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805198

The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805198

Structure of the human type IV collagenase gene

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805198

Interaction of 92-kDa type IV collagenase with the tissue inhibitor of metalloproteinases prevents dimerization, complex formation with interstitial collagenase, and activation of the proenzyme with stromelysin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805198

Differential expression of protease activated receptor 1 (Par1) and pY397FAK in benign and malignant human ovarian tissue samples

21 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704855200

Tumor cell invasion is promoted by activation of protease activated receptor-1 in cooperation with the alpha vbeta 5 integrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704855200

C-Met overexpression in node-positive breast cancer identifies patients with poor clinical outcome independent of Her2/neu

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704855200

The clinicopathological and prognostic significance of membrane type 1 matrix metalloproteinase (MT1-MMP) and MMP-9 according to their localization in invasive breast carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704855200

Requirement of receptor-bound urokinase-type plasminogen activator for integrin alphavbeta5-directed cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704855200

Generation of a minimal alpha5beta1 integrin-Fc fragment

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704855200

The Ets-1 and Ets-2 transcription factors activate the promoters for invasion-associated urokinase and collagenase genes in response to epidermal growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704855200

Modulation of angiogenesis and progelatinase a by thrombin receptor mimetics and antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704855200

Role of MMP-9 and its tissue inhibitor TIMP-1 in human osteosarcoma: findings in 42 patients followed for 1-16 years

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805198

Increased expression of matrix metalloproteinases (MMP)-2, MMP-9, and the urokinase-type plasminogen activator is associated with progression from benign to advanced ovarian cancer

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805198

Protease crosstalk with integrins: the urokinase receptor paradigm.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805198

Phosphatidylinositol 3-kinase activity in epidermal growth factor-stimulated matrix metalloproteinase-9 production and cell surface association.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805198

Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805198

v-Src activates the expression of 92-kDa type IV collagenase gene through the AP-1 site and the GT box homologous to retinoblastoma control elements. A mechanism regulating gene expression independent of that by inflammatory cytokines

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805198

Characterization of the monomeric and dimeric forms of latent and active matrix metalloproteinase-9. Differential rates for activation by stromelysin 1

31 October 2018

1 reference

12 December 2020

c-Met overexpression is a prognostic factor in ovarian cancer and an effective target for inhibition of peritoneal dissemination and invasion

1 reference

12 December 2020

Substrate binding of gelatinase B induces its enzymatic activity in the presence of intact propeptide

1 reference

12 December 2020

Thrombin is present in the lungs of patients with primary extremity osteosarcoma and pulmonary metastases

1 reference

12 December 2020

Pro-MMP-9 activation by the MT1-MMP/MMP-2 axis and MMP-3: role of TIMP-2 and plasma membranes

1 reference

12 December 2020

Thrombin increases the metastatic potential of tumor cells

1 reference

12 December 2020

Inhibition of matrix metalloproteinase 9 activation by a specific monoclonal antibody

1 reference

12 December 2020

Thrombin induces the activation of progelatinase A in vascular endothelial cells. Physiologic regulation of angiogenesis

1 reference

12 December 2020

Thrombin induces activation of p38 MAP kinase in human platelets

1 reference

12 December 2020

Thrombin receptor activating peptide (TRAP) stimulates mitogenesis, c-fos and PDGF-A gene expression in human vascular smooth muscle cells

1 reference

12 December 2020

Phorbol ester-induced cell surface association of matrix metalloproteinase-9 in human MCF10A breast epithelial cells

1 reference

12 December 2020

Insulin-like growth factor I-triggered cell migration and invasion are mediated by matrix metalloproteinase-9

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M704855200

1 reference

28 July 2017

1 reference

28 July 2017

1 reference