(Q33604570)

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Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects

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scholarly article

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Europe PubMed Central

28 July 2017

Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects (English)

1 reference

Europe PubMed Central

28 July 2017

Carla J Greenbaum

10

object named as

Carla Greenbaum

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Europe PubMed Central

28 July 2017

Catherine Pihoker

8

object named as

Catherine Pihoker

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Europe PubMed Central

28 July 2017

author name string

S Alice Long

1

1 reference

Europe PubMed Central

28 July 2017

Karen Cerosaletti

2

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Europe PubMed Central

28 July 2017

Paul L Bollyky

3

1 reference

Europe PubMed Central

28 July 2017

Megan Tatum

4

1 reference

Europe PubMed Central

28 July 2017

Heather Shilling

5

1 reference

Europe PubMed Central

28 July 2017

Sheng Zhang

6

1 reference

Europe PubMed Central

28 July 2017

Zhong-Yin Zhang

7

1 reference

Europe PubMed Central

28 July 2017

Srinath Sanda

9

1 reference

Europe PubMed Central

28 July 2017

Jane H Buckner

11

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Europe PubMed Central

28 July 2017

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publication date

29 October 2009

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Europe PubMed Central

28 July 2017

number of pages

9

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Europe PubMed Central

28 July 2017

59

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Europe PubMed Central

28 July 2017

2

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Europe PubMed Central

28 July 2017

407-415

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Europe PubMed Central

28 July 2017

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

28 August 2021

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April 2022 Public Data File from Crossref

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2809970/fullTextXML

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Acquisition of a potent and selective TC-PTP inhibitor via a stepwise fluorophore-tagged combinatorial synthesis and screening strategy

1 reference

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21 June 2018

PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis

1 reference

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T-cell protein tyrosine phosphatase is a key regulator in immune cell signaling: lessons from the knockout mouse model and implications in human disease

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21 June 2018

A low interleukin-2 receptor signaling threshold supports the development and homeostasis of T regulatory cells

1 reference

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21 June 2018

Functional islet-specific Treg can be generated from CD4+CD25- T cells of healthy and type 1 diabetic subjects

1 reference

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21 June 2018

The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells

1 reference

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21 June 2018

Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci

1 reference

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21 June 2018

The IL-2/CD25 pathway determines susceptibility to T1D in humans and NOD mice

1 reference

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A function for IL-7R for CD4+CD25+Foxp3+ T regulatory cells

1 reference

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21 June 2018

Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction

1 reference

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21 June 2018

Combination of rapamycin and IL-2 increases de novo induction of human CD4(+)CD25(+)FOXP3(+) T cells

1 reference

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21 June 2018

FOXP3 promoter demethylation reveals the committed Treg population in humans.

1 reference

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21 June 2018

STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25- effector T cells.

1 reference

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21 June 2018

Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire.

1 reference

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21 June 2018

A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study

1 reference

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21 June 2018

The biology of interleukin-2.

1 reference

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21 June 2018

Interleukin-2 receptor signaling in regulatory T cell development and homeostasis

1 reference

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21 June 2018

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

1 reference

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21 June 2018

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

1 reference

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21 June 2018

Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity

1 reference

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21 June 2018

FOXP3: not just for regulatory T cells anymore

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809970

21 June 2018

IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo

1 reference

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21 June 2018

Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen

1 reference

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21 June 2018

A function for interleukin 2 in Foxp3-expressing regulatory T cells

1 reference

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21 June 2018

NOD mice and autoimmunity

1 reference

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21 June 2018

Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes.

1 reference

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Cytokines and immunodeficiency diseases: critical roles of the gamma(c)-dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways

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Natural versus adaptive regulatory T cells

1 reference

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The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3

1 reference

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Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1 reference

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Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells

1 reference

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cDNA isolated from a human T-cell library encodes a member of the protein-tyrosine-phosphatase family

1 reference

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Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor

1 reference

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30 October 2018

Functional waning of naturally occurring CD4+ regulatory T-cells contributes to the onset of autoimmune diabetes.

1 reference

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30 October 2018

DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells.

1 reference

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30 October 2018

Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.

1 reference

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30 October 2018

IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells

1 reference

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30 October 2018

IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells.

1 reference

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30 October 2018

Cutting edge: Decreased accumulation and regulatory function of CD4+ CD25(high) T cells in human STAT5b deficiency

1 reference

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30 October 2018

Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion.

1 reference

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30 October 2018

Constitutive activation of STAT5 supersedes the requirement for cytokine and TCR engagement of CD4+ T cells in steady-state homeostasis

1 reference

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A reduced IL2R (CD25) expression level in first and second degree female relatives of autoimmune thyroid disease patients. A sign of a poor capability to preserve tolerance?

1 reference

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Emerging challenges in regulatory T cell function and biology

1 reference

https://pubmed.ncbi.nlm.nih.gov/19875613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impact of protective IL-2 allelic variants on CD4+ Foxp3+ regulatory T cell function in situ and resistance to autoimmune diabetes in NOD mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19875613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/19875613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19875613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the murine immunological signaling network with phosphospecific flow cytometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/19875613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective availability of IL-2 is a major determinant controlling the production of CD4+CD25+Foxp3+ T regulatory cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19875613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

No alterations in the frequency of FOXP3+ regulatory T-cells in type 1 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19875613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2337/DB09-0694

1 reference

Europe PubMed Central

28 July 2017

1 reference

Europe PubMed Central

28 July 2017

1 reference

Europe PubMed Central

28 July 2017

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