(Q33623477)

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Digital expression profiling identifies RUNX2, CDC5L, MDM2, RECQL4, and CDK4 as potential predictive biomarkers for neo-adjuvant chemotherapy response in paediatric osteosarcoma

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scholarly article

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Europe PubMed Central

PubMed publication ID

28 July 2017

Digital expression profiling identifies RUNX2, CDC5L, MDM2, RECQL4, and CDK4 as potential predictive biomarkers for neo-adjuvant chemotherapy response in paediatric osteosarcoma (English)

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Europe PubMed Central

PubMed publication ID

28 July 2017

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Jeremy A. Squire

object named as

Jeremy A Squire

5

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Andre J van Wijnen

4

object named as

Andre J van Wijnen

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Europe PubMed Central

PubMed publication ID

28 July 2017

author name string

Jeffrey W Martin

1

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Europe PubMed Central

PubMed publication ID

28 July 2017

Susan Chilton-MacNeill

2

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Europe PubMed Central

PubMed publication ID

28 July 2017

Madhuri Koti

3

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Europe PubMed Central

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28 July 2017

Maria Zielenska

6

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Europe PubMed Central

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28 July 2017

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publication date

16 May 2014

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Europe PubMed Central

PubMed publication ID

28 July 2017

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Europe PubMed Central

PubMed publication ID

28 July 2017

9

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Europe PubMed Central

PubMed publication ID

28 July 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

e95843

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Europe PubMed Central

PubMed publication ID

28 July 2017

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Creative Commons Attribution 4.0 International

16 May 2014

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April 2022 Public Data File from Crossref

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MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor p53 in osteosarcoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

MicroRNA paraffin-based studies in osteosarcoma reveal reproducible independent prognostic profiles at 14q32.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

The cancer-related transcription factor Runx2 modulates cell proliferation in human osteosarcoma cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

p21 promotes error-free replication-coupled DNA double-strand break repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

The genetics of osteosarcoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

Global gene expression profiling of human osteosarcomas reveals metastasis-associated chemokine pattern

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

Identification of osteosarcoma driver genes by integrative analysis of copy number and gene expression data.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

MDM2 and CDK4 immunohistochemical coexpression in high-grade osteosarcoma: correlation with a dedifferentiated subtype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

Runx2 protein expression utilizes the Runx2 P1 promoter to establish osteoprogenitor cell number for normal bone formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

Molecular subtypes of osteosarcoma identified by reducing tumor heterogeneity through an interspecies comparative approach

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

The molecular pathogenesis of osteosarcoma: a review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

The Role of RUNX2 in Osteosarcoma Oncogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

Validated prediction of clinical outcome in sarcomas and multiple types of cancer on the basis of a gene expression signature related to genome complexity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

Functional and biological analysis of Bcl-xL expression in human osteosarcoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

Frequent attenuation of the WWOX tumor suppressor in osteosarcoma is associated with increased tumorigenicity and aberrant RUNX2 expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

Expression analysis of genes associated with human osteosarcoma tumors shows correlation of RUNX2 overexpression with poor response to chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

Human RECQ1 and RECQ4 helicases play distinct roles in DNA replication initiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

Profiling of high-grade central osteosarcoma and its putative progenitor cells identifies tumourigenic pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

Cdc5L interacts with ATR and is required for the S-phase cell-cycle checkpoint

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

Cell cycle kinases as therapeutic targets for cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

Multiplexed measurements of gene signatures in different analytes using the Nanostring nCounter Assay System

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

Recurrent RECQL4 imbalance and increased gene expression levels are associated with structural chromosomal instability in sporadic osteosarcoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

Control of mitochondrial apoptosis by the Bcl-2 family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

Elevated expression of Runx2 as a key parameter in the etiology of osteosarcoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

Genomic signatures of chromosomal instability and osteosarcoma progression detected by high resolution array CGH and interphase FISH.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

Copy number gains in EGFR and copy number losses in PTEN are common events in osteosarcoma tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

Cell cycle regulator gene CDC5L, a potential target for 6p12-p21 amplicon in osteosarcoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

Direct multiplexed measurement of gene expression with color-coded probe pairs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

A review of clinical and molecular prognostic factors in osteosarcoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

Cell cycle kinases in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

Effects of THBS3, SPARC and SPP1 expression on biological behavior and survival in patients with osteosarcoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

HES1 cooperates with pRb to activate RUNX2-dependent transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

Housekeeping genes as internal standards in cancer research

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

Conservation and expression of an alternative 3' exon of Runx2 encoding a novel proline-rich C-terminal domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

Mechanisms of sarcoma development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

Association between osteosarcoma and deleterious mutations in the RECQL4 gene in Rothmund-Thomson syndrome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

Expression of apoptosis and cell cycle related genes in proliferating and colcemid arrested cells of divergent lineage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

Genomic structure and isoform expression of the mouse, rat and human Cbfa1/Osf2 transcription factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

A mammalian homolog of fission yeast Cdc5 regulates G2 progression and mitotic entry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

Mdm2 promotes the rapid degradation of p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

21 June 2018

Identification of interactive networks of gene expression associated with osteosarcoma oncogenesis by integrated molecular profiling.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0095843

21 January 2018

c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0095843

21 January 2018

Small deletions but not methylation underlie CDKN2A/p16 loss of expression in conventional osteosarcoma.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0095843

21 January 2018

12q amplification defines a subtype of extraskeletal osteosarcoma with good prognosis that is the soft tissue homologue of parosteal osteosarcoma.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0095843

21 January 2018

Prognostic implication of immunohistochemical Runx2 expression in osteosarcoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

30 October 2018

C-myc and c-fos in human osteosarcoma: prognostic value of mRNA and protein expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4023931

30 October 2018

Loss of heterozygosity of the RB gene is a poor prognostic factor in patients with osteosarcoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/24835790

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols

1 reference

https://pubmed.ncbi.nlm.nih.gov/24835790

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhancement of drug-induced apoptosis by antisense oligodeoxynucleotides targeted against Mdm2 and p21WAF1/CIP1

1 reference

https://pubmed.ncbi.nlm.nih.gov/24835790

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MDM2 and CDK4 immunohistochemistry is a valuable tool in the differential diagnosis of low-grade osteosarcomas and other primary fibro-osseous lesions of the bone

1 reference

https://pubmed.ncbi.nlm.nih.gov/24835790

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TP53Mutations and Outcome in Osteosarcoma: A Prospective, Multicenter Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/24835790

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of the p16INK4, p14ARF, p15, TP53, and MDM2 genes and their prognostic implications in osteosarcoma and Ewing sarcoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/24835790

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genomic Alterations and Allelic Imbalances Are Strong Prognostic Predictors in Osteosarcoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/24835790

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic heterogeneity and cancer drug resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/24835790

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transitional CpG methylation between promoters and retroelements of tissue-specific genes during human mesenchymal cell differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24835790

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0095843

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

2014PLoSO...995843M

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1 reference

https://api.fatcat.wiki/v0/release/zyvgg4gqv5gl5iqyksykjazoam

24 November 2022

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mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

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