(Q33630479)

28 July 2017

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title

Polymorphic cytochromes P450 and drugs used in psychiatry (English)

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28 July 2017

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Coutts RT

1

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28 July 2017

Urichuk LJ

series ordinal

2

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28 July 2017

publication date

1 June 1999

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Cellular and Molecular Neurobiology

28 July 2017

published in

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28 July 2017

volume

19

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28 July 2017

issue

3

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28 July 2017

page(s)

325-354

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https://scigraph.springernature.com/pub.10.1023/a:1006945715127

28 July 2017

exact match

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cites work

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Genetic basis for a lower prevalence of deficient CYP2D6 oxidative drug metabolism phenotypes in black Americans

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A missense mutation in exon 6 of the CYP2D6 gene leading to a histidine 324 to proline exchange is associated with the poor metabolizer phenotype of sparteine

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Maprotiline metabolism appears to co-segregate with the genetically-determined CYP2D6 polymorphic hydroxylation of debrisoquine

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Pharmacokinetics of desipramine coadministered with sertraline or fluoxetine

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Debrisoquine hydroxylation phenotyping in geriatric psychopharmacology

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Influence of amino acid residue 374 of cytochrome P-450 2D6 (CYP2D6) on the regio- and enantio-selective metabolism of metoprolol

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Pharmacogenetic phenotyping and genotyping. Present status and future potential.

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12 December 2020

Identification of the human cytochromes P450 responsible for the in vitro formation of the major oxidative metabolites of the antipsychotic agent olanzapine.

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12 December 2020

Diazepam metabolism by human liver microsomes is mediated by both S-mephenytoin hydroxylase and CYP3A isoforms

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12 December 2020

Influence of neuroleptics and benzodiazepines on metabolism of tricyclic antidepressants in man.

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12 December 2020

Genetic and metabolic criteria for the assignment of debrisoquine 4-hydroxylation (cytochrome P4502D6) phenotypes

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12 December 2020

Role of P450IID6, the target of the sparteine-debrisoquin oxidation polymorphism, in the metabolism of imipramine

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12 December 2020

Slow hydroxylation of nortriptyline and concomitant poor debrisoquine hydroxylation: clinical implications

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12 December 2020

Stereoselectivity of the arene epoxide pathway of mephenytoin hydroxylation in man.

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12 December 2020

Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations

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12 December 2020

Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22.

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12 December 2020

Cytochrome P450 enzymes: interpretation of their interactions with selective serotonin reuptake inhibitors. Part I.

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12 December 2020

P450 enzymes and Parkinson's disease: the story so far.

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12 December 2020

pNAT and CYP2D6 gene polymorphism in epileptic patients

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12 December 2020

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

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12 December 2020

Influences of diet and nutrition on clinical pharmacokinetics

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12 December 2020

Phenotyping and genotyping of S-mephenytoin hydroxylase (cytochrome P450 2C19) in a Shona population of Zimbabwe

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12 December 2020

Genetic polymorphism of cytochromes P450 1A1, 2D6 and 2E1: regulation and toxicological significance.

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12 December 2020

Moclobemide, a substrate of CYP2C19 and an inhibitor of CYP2C19, CYP2D6, and CYP1A2: A panel study*

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12 December 2020

Incidence of S-mephenytoin hydroxylation deficiency in a Korean population and the interphenotypic differences in diazepam pharmacokinetics.

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12 December 2020

Drug Interaction: Inhibitory Effect of Neuroleptics on Metabolism of Tricyclic Antidepressants in Man

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12 December 2020

Importance of oxidative polymorphism and levomepromazine treatment on the steady-state blood concentrations of clomipramine and its major metabolites

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12 December 2020

Geographical/interracial differences in polymorphic drug oxidation. Current state of knowledge of cytochromes P450 (CYP) 2D6 and 2C19

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12 December 2020

Stereoselective disposition of mianserin is related to debrisoquin hydroxylation polymorphism

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12 December 2020

Genetic polymorphism of cytochrome P450 CYP2D6 in Zimbabwean population

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12 December 2020

Debrisoquine and dextromethorphan phenotyping and antidepressant treatment

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12 December 2020

An association study of debrisoquine hydroxylase (CYP2D6) polymorphisms in schizophrenia

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12 December 2020

N-acetylation and debrisoquine type oxidation polymorphism in Caucasians--with reference to age and sex.

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12 December 2020

Molecular basis of genetic variation in debrisoquin hydroxylation in Chinese subjects: polymorphism in RFLP and DNA sequence of CYP2D6

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12 December 2020

The role of S-mephenytoin 4'-hydroxylase in imipramine metabolism by human liver microsomes: a two-enzyme kinetic analysis of N-demethylation and 2-hydroxylation

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12 December 2020

Pharmacokinetics of citalopram in relation to the sparteine and the mephenytoin oxidation polymorphisms

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12 December 2020

A refined substrate model for human cytochrome P450 2D6

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12 December 2020

Importance of genetic factors in the regulation of diazepam metabolism: relationship to S-mephenytoin, but not debrisoquin, hydroxylation phenotype.

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12 December 2020

Plasma levels of the enantiomers of thioridazine, thioridazine 2-sulfoxide, thioridazine 2-sulfone, and thioridazine 5-sulfoxide in poor and extensive metabolizers of dextromethorphan and mephenytoin.

1 reference

12 December 2020

The antipsychotic clozapine is metabolized by the polymorphic human microsomal and recombinant cytochrome P450 2D6

1 reference

12 December 2020

A novel cytochrome P-450IID6 mutant gene associated with Parkinson's disease

1 reference

12 December 2020

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is N-demethylated by cytochromes P450 2D6, 1A2 and 3A4--implications for susceptibility to Parkinson's disease.

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12 December 2020

Interaction of Perphenazine with the Kinetics of Nortriptyline

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12 December 2020

Inhibition of CYP2C9 by selective serotonin reuptake inhibitors in vitro: studies of phenytoin p-hydroxylation

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12 December 2020

Impaired (S)-warfarin metabolism catalysed by the R144C allelic variant of CYP2C9

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12 December 2020

Genetic polymorphisms for drug metabolism (CYP2D6) and tardive dyskinesia in schizophrenia

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12 December 2020

Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation.

1 reference

12 December 2020

Non-functional CYP2D6 alleles and risk for neuroleptic-induced movement disorders in schizophrenic patients

1 reference

12 December 2020

Introduction of a composite parameter to the pharmacokinetics of venlafaxine and its active O-desmethyl metabolite

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12 December 2020

Differences in the effects of clomipramine on English and Asian volunteers. Preliminary report on a pilot study

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12 December 2020

Active-site topologies of human CYP2D6 and its aspartate-301 --> glutamate, asparagine, and glycine mutants.

1 reference

12 December 2020

Metabolism of trimipramine in vitro by human CYP2D6 isozyme

1 reference

12 December 2020

Roles of cytochrome P-450 enzymes in chemical carcinogenesis and cancer chemotherapy.

1 reference

12 December 2020

Pharmacokinetics of omeprazole (a substrate of CYP2C19) and comparison with two mutant alleles, C gamma P2C19m1 in exon 5 and C gamma P2C19m2 in exon 4, in Japanese subjects

1 reference

12 December 2020

Variant cytochrome P450 CYP2D6 allelic frequencies in Parkinson's disease

1 reference

12 December 2020

Relationship between mephenytoin oxidation polymorphism and phenytoin, methylphenytoin and phenobarbitone hydroxylation assessed in a phenotyped panel of healthy subjects

1 reference

12 December 2020

Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans

1 reference

12 December 2020

Fluvoxamine and fluoxetine: interaction studies with amitriptyline, clomipramine and neuroleptics in phenotyped patients

1 reference

12 December 2020

Pharmacogenetics of antidepressants: clinical aspects

1 reference

12 December 2020

Characterization of the common genetic defect in humans deficient in debrisoquine metabolism

1 reference

12 December 2020

Single and multiple dose pharmacokinetics of nefazodone in subjects classified as extensive and poor metabolizers of dextromethorphan

1 reference

12 December 2020

Environmental factors affecting antipyrine metabolism in London factory and office workers

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12 December 2020

Molecular genetics of the debrisoquin-sparteine polymorphism

1 reference

12 December 2020

Polymorphic drug metabolism in schizophrenic patients with tardive dyskinesia

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12 December 2020

Analysis of the CYP2D6 gene in relation to debrisoquin and desipramine hydroxylation in a Swedish population

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12 December 2020

The directory of P450-containing systems on WorldWide Web.

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12 December 2020

Debrisoquine hydroxylase and Parkinson's disease

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12 December 2020

Comparison of chloroguanide and mephenytoin for the in vivo assessment of genetically determined CYP2C19 activity in humans.

1 reference

12 December 2020

Prevalence of CYP2D6 gene duplication and its repercussion on the oxidative phenotype in a white population

1 reference

12 December 2020

The sparteine/debrisoquine (CYP2D6) oxidation polymorphism and the risk of lung cancer: a meta-analysis.

1 reference

12 December 2020

Polymorphism in the metabolism of drugs, including antidepressant drugs: comments on phenotyping

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12 December 2020

Neuronal cytochrome P450IID1 (debrisoquine/sparteine-type): potent inhibition of activity by (-)-cocaine and nucleotide sequence identity to human hepatic P450 gene CYP2D6

1 reference

12 December 2020

Contribution of Environmental Factors to Variability in Human Drug Metabolism

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12 December 2020

Relationship of N-demethylation of amiflamine and its metabolite to debrisoquine hydroxylation polymorphism

1 reference

12 December 2020

Atypical metabolism of deprenyl and its enantiomer, (S)-(+)-N,alpha-dimethyl-N-propynylphenethylamine, by cytochrome P450 2D6.

1 reference

12 December 2020

A 2.4-megabase physical map spanning the CYP2C gene cluster on chromosome 10q24

1 reference

12 December 2020

Antidepressants and drug-metabolizing enzymes--expert group report

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12 December 2020

The hydroxylation of omeprazole correlates with S-mephenytoin metabolism: a population study

1 reference

12 December 2020

Genetic linkage studies in autosomal dominant parkinsonism: evaluation of seven candidate genes

1 reference

12 December 2020

The CYP2D6 genotype predicts the oral clearance of the neuroleptic agents perphenazine and zuclopenthixol.

1 reference

12 December 2020

Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations

1 reference

12 December 2020

Metoprolol and mephenytoin oxidation polymorphisms in Far Eastern Oriental subjects: Japanese versus mainland Chinese

1 reference

12 December 2020

Disposition of perphenazine is related to polymorphic debrisoquin hydroxylation in human beings

1 reference

12 December 2020

Nonlinear kinetics after high-dose omeprazole caused by saturation of genetically variable CYP2C19.

1 reference

12 December 2020

Inhibitors of imipramine metabolism by human liver microsomes

1 reference

12 December 2020

The polymorphic cytochrome P-4502D6 is involved in the metabolism of both 5-hydroxytryptamine antagonists, tropisetron and ondansetron

1 reference

12 December 2020

Pharmacogenetics of mephenytoin: a new drug hydroxylation polymorphism in man

1 reference

12 December 2020

The role of S-mephenytoin hydroxylase (CYP2C19) in the metabolism of the antimalarial biguanides

1 reference

12 December 2020

Debrisoquine hydroxylation polymorphism and personality

1 reference

12 December 2020

Enantioselective amitriptyline metabolism in patients phenotyped for two cytochrome P450 isozymes

1 reference

12 December 2020

The evolving science of pharmacogenetics: clinical and ethnic perspectives.

1 reference

12 December 2020

Genetically determined drug-metabolizing activity and desipramine-associated cardiotoxicity: a case report

1 reference

12 December 2020

Genetic analysis of the CYP2D locus in relation to debrisoquine hydroxylation capacity in Korean, Japanese and Chinese subjects.

1 reference

12 December 2020

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

1 reference

12 December 2020

Concordance of P450 2D6 (debrisoquine hydroxylase) phenotype and genotype: inability of dextromethorphan metabolic ratio to discriminate reliably heterozygous and homozygous extensive metabolizers

1 reference

12 December 2020

Quantification and mechanism of the fluoxetine and tricyclic antidepressant interaction

1 reference

12 December 2020

The biotransformation of clomipramine in vitro, identification of the cytochrome P450s responsible for the separate metabolic pathways

1 reference

12 December 2020

Evolution of a highly polymorphic human cytochrome P450 gene cluster: CYP2D6.

1 reference

12 December 2020

Inhibition of trazodone metabolism by thioridazine in humans

1 reference

12 December 2020

Genetic analysis of the interethnic difference between Chinese and Caucasians in the polymorphic metabolism of debrisoquine and codeine

1 reference

12 December 2020

CYP2D6-debrisoquine hydroxylase gene polymorphism in multiple system atrophy.

1 reference

12 December 2020

The role of cytochrome P4502D6 in the metabolism of paroxetine by human liver microsomes

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12 December 2020

A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population.

1 reference

12 December 2020

S-mephenytoin 4-hydroxylation in older Americans

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12 December 2020

Human-liver cytochromes P-450 involved in polymorphisms of drug oxidation

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12 December 2020

Frequency of human CYP2D6 mutant alleles in a normal Chinese population

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12 December 2020

Potent inhibition of yeast-expressed CYP2D6 by dihydroquinidine, quinidine, and its metabolites

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12 December 2020

The effect of selective serotonin re-uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes

1 reference

12 December 2020

Involvement of CYP2D6, CYP3A4, and other cytochrome P-450 isozymes in N-dealkylation reactions

1 reference

12 December 2020

Pharmacokinetic drug interactions of new antidepressants: a review of the effects on the metabolism of other drugs

1 reference

12 December 2020

Study of the metabolism of phenothiazines: determination of N-demethylated phenothiazines in urine

1 reference

12 December 2020

Genetic polymorphism of mephenytoin p(4')-hydroxylation: difference between Orientals and Caucasians

1 reference

12 December 2020

Assay of mephenytoin metabolism in human liver microsomes by high-performance liquid chromatography

1 reference

12 December 2020

In vitro inhibition studies of two isozymes of human liver cytochrome P-450. Mephenytoin p-hydroxylase and sparteine monooxygenase

1 reference

12 December 2020

Drug therapy: drug disposition in old age.

1 reference

12 December 2020

The cytochrome P450 CYP2D6 allelic variant CYP2D6J and related polymorphisms in a European population

1 reference

12 December 2020

First-pass metabolism of imipramine and desipramine: Impact of the sparteine oxidation phenotype

1 reference

12 December 2020

The relationship between paroxetine and the sparteine oxidation polymorphism

1 reference

12 December 2020

"It's the genes, stupid". Molecular bases and clinical consequences of genetic cytochrome P450 2D6 polymorphism

1 reference

12 December 2020

Assessment of the debrisoquin and dextromethorphan phenotyping tests by gaussian mixture distributions analysis.

1 reference

12 December 2020

17 Genetic polymorphism of debrisoquine oxidation: restriction fragment analysis and allele-specific amplification of mutant alleles of CYP2D6

1 reference

12 December 2020

Diazepam metabolism in native Chinese poor and extensive hydroxylators of S-mephenytoin: interethnic differences in comparison with white subjects.

1 reference

12 December 2020

Polymorphic hydroxylation of Debrisoquine in man.

1 reference

12 December 2020

Gene-environment interaction in parkinson's disease. The case of CYP2D6 gene polymorphism.

1 reference

12 December 2020

Ethnic differences in drug response.

1 reference

12 December 2020

Recent developments in hepatic drug oxidation. Implications for clinical pharmacokinetics

1 reference

12 December 2020

Genetic basis for differences in debrisoquin polymorphism between a Spanish and other white populations

1 reference

12 December 2020

Debrisoquine oxidation phenotype during neuroleptic monotherapy

1 reference

12 December 2020

Allelic variants of human cytochrome P450 2C9: baculovirus-mediated expression, purification, structural characterization, substrate stereoselectivity, and prochiral selectivity of the wild-type and I359L mutant forms.

1 reference

12 December 2020

Isolation and characterization of human liver cytochrome P450 2C19: correlation between 2C19 and S-mephenytoin 4'-hydroxylation

1 reference

12 December 2020

Cytochrome P4502C9: an enzyme of major importance in human drug metabolism

1 reference

12 December 2020

Association between the oxidative polymorphism and early onset of Parkinson's disease

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12 December 2020

Clinical pharmacokinetics of clomipramine

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12 December 2020

Venlafaxine oxidation in vitro is catalysed by CYP2D6.

1 reference

12 December 2020

Effects of felbamate on the pharmacokinetics of phenobarbital

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12 December 2020

Inhibition by paroxetine of desipramine metabolism in extensive but not in poor metabolizers of sparteine

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12 December 2020

Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease

1 reference

12 December 2020

No association between schizophrenia and polymorphisms within the genes for debrisoquine 4-hydroxylase (CYP2D6) and the dopamine transporter (DAT).

1 reference

12 December 2020

Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin

1 reference

12 December 2020

Role of cytochrome P4502D6 in the metabolism of brofaromine. A new selective MAO-A inhibitor

1 reference

12 December 2020

Involvement of CYP3A4 and CYP2D6 in the metabolism of haloperidol

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12 December 2020

Haloperidol disposition is dependent on debrisoquine hydroxylation phenotype

1 reference

12 December 2020

Single-dose kinetics of clomipramine: relationship to the sparteine and S-mephenytoin oxidation polymorphisms

1 reference

12 December 2020

Are poor metabolisers of sparteine/debrisoquine less pain tolerant than extensive metabolisers?

1 reference

12 December 2020

An inactive cytochrome P450 CYP2D6 allele containing a deletion and a base substitution

1 reference

12 December 2020

Amitriptyline metabolism: relationship to polymorphic debrisoquine hydroxylation

1 reference

12 December 2020

Plasma levels of thioridazine and metabolites are influenced by the debrisoquin hydroxylation phenotype

1 reference

12 December 2020

Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes

1 reference

12 December 2020

Identification of the human P450 enzymes involved in lansoprazole metabolism.

1 reference

12 December 2020

The demethylenation of methylenedioxymethamphetamine ("ecstasy") by debrisoquine hydroxylase (CYP2D6)

1 reference

12 December 2020

Chloroguanide metabolism in relation to the efficacy in malaria prophylaxis and the S-mephenytoin oxidation in Tanzanians.

1 reference

12 December 2020

Fluoxetine-induced tricyclic toxicity: extent and duration

1 reference

12 December 2020

Relationship between genotype for the cytochrome P450 CYP2D6 and susceptibility to ankylosing spondylitis and rheumatoid arthritis

1 reference

12 December 2020

The CYP2D6B mutant allele is overrepresented in the Lewy body variant of Alzheimer's disease.

1 reference

12 December 2020

A novel CYP2D6 allele with an abolished splice recognition site associated with the poor metabolizer phenotype

1 reference

12 December 2020

Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism

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12 December 2020

Metabolism of amitriptyline with CYP2D6 expressed in a human cell line

1 reference

12 December 2020

Debrisoquine/sparteine hydroxylation genotype and phenotype: analysis of common mutations and alleles of CYP2D6 in a European population

1 reference

12 December 2020

Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese

1 reference

12 December 2020

Genetic analysis of the cytochrome P450 CYP2D6 polymorphism in patients with systemic lupus erythematosus.

1 reference

12 December 2020

An additional allelic variant of the CYP2D6 gene causing impaired metabolism of sparteine

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12 December 2020

The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans

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12 December 2020

Mutant debrisoquine hydroxylation genes in Parkinson's disease

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12 December 2020

Involvement of the cytochrome P-450IID subfamily in minaprine 4-hydroxylation by human hepatic microsomes

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12 December 2020

Analysis of imipramine and three metabolites produced by isozyme CYP2D6 expressed in a human cell line

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12 December 2020

A PET study of D2 and 5-HT2 receptor occupancy induced by risperidone in poor metabolizers of debrisoquin and risperidone

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12 December 2020

Mephenytoin hydroxylation deficiency: kinetics after repeated doses

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12 December 2020

Identifiers

DOI

10.1023/A:1006945715127

1 reference

Dimensions Publication ID

28 July 2017

1051315552

0 references

1 reference